Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis

Henderson, Lauren A.; Hoyt, Kacie J.; Lee, Pui Y.; Rao, Deepak A.; Jonsson, Helena; Nguyen, Jennifer; Rutherford, Kayleigh D.; Julé, Amélie M.; Charbonnier, Louis-Marie; Case, Siobhan; Chang, Margaret H.; Cohen, Ezra; Dedeoğlu, Fatma; Fuhlbrigge, Robert C.; Halyabar, Olha; Hazen, Melissa; Janssen, Erin; Kim, Susan; Lo, Jeffrey; Lo, Mindy S.; Meidan, Esra; Son, Mary Beth; Sundel, Robert P.; Stoll, Matthew L.; Nusbaum, Chad; Lederer, James A.; Chatila, Talal; Nigrović, Peter A.

doi:10.1172/jci.insight.132508

Cited by 50 publications

(47 citation statements)

References 95 publications

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“…Due to their central role in the differentiation of Th17 cells, the two cytokines IL-1β and IL-6 may be a key to understand the disease evolution of SoJIA [ 126 , 127 ]. Two recent studies analysing cells from patients with SoJIA give evidence that an IL-1-blockade prevents and/or reverses the differentiation of ɣ/δ T cells and regulatory T cells into a Th17 phenotype [ 128 , 129 ].…”

Section: Still’s Disease In Children and Adults—is There A Differementioning

confidence: 99%

Adult-Onset Still’s Disease: Clinical Aspects and Therapeutic Approach

Tomaras¹,

Goetzke

Kallinich

et al. 2021

JCM

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Adult-onset Still’s disease (AoSD) is a rare systemic autoinflammatory disease characterized by arthritis, spiking fever, skin rash and elevated ferritin levels. The reason behind the nomenclature of this condition is that AoSD shares certain symptoms with Still’s disease in children, currently named systemic-onset juvenile idiopathic arthritis. Immune dysregulation plays a central role in AoSD and is characterized by pathogenic involvement of both arms of the immune system. Furthermore, the past two decades have seen a large body of immunological research on cytokines, which has attributed to both a better understanding of AoSD and revolutionary advances in treatment. Additionally, recent studies have introduced a new approach by grouping patients with AoSD into only two phenotypes: one with predominantly systemic features and one with a chronic articular disease course. Diagnosis presupposes an extensive diagnostic workup to rule out infections and malignancies. The severe end of the spectrum of this disease is secondary haemophagocytic lymphohistiocytosis, better known as macrophage activation syndrome. In this review, we discuss current research conducted on the pathogenesis, diagnosis, classification, biomarkers and complications of AoSD, as well as the treatment strategy at each stage of the disease course. We also highlight the similarities and differences between AoSD and systemic-onset juvenile idiopathic arthritis. There is a considerable need for large multicentric prospective trials.

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Section: Still’s Disease In Children and Adults—is There A Differementioning

confidence: 99%

Adult-Onset Still’s Disease: Clinical Aspects and Therapeutic Approach

Tomaras¹,

Goetzke

Kallinich

et al. 2021

JCM

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show abstract

“…These features resemble those of other autoinflammatory diseases, but an HLA association and characteristic changes in T cells suggest that (like PFAPA) this phenotype is unlikely to be ''purely'' autoinflammatory. [129][130][131] Inflammatory bowel disease likely reflects both immune hyperresponsiveness and defects in mucosal barrier function. 132 The autoinflammatory penumbra is to be expected.…”

Section: The ''Autoinflammatory Penumbra''mentioning

confidence: 99%

Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

Nigrović

Lee

Hoffman

2020

Journal of Allergy and Clinical Immunology

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110

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“…Tregs, which express interleukin-17 A (IL-17A), are more commonly found in the blood of patients with an acute sJIA phase with high inflammatory markers than in patients with acute nonsystemic JIA and healthy controls [28]. Early in-…”

Section: Pathogenesismentioning

confidence: 99%

Current Review of Systemic Juvenile Idiopathic Arthritis: What Do Paediatricians Need to Know?

Albaker¹

2020

OJPed

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Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis

Cited by 50 publications

References 95 publications

Adult-Onset Still’s Disease: Clinical Aspects and Therapeutic Approach

Adult-Onset Still’s Disease: Clinical Aspects and Therapeutic Approach

Monogenic autoinflammatory disorders: Conceptual overview, phenotype, and clinical approach

Current Review of Systemic Juvenile Idiopathic Arthritis: What Do Paediatricians Need to Know?

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