Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis

Zheng, Ying; Chai, Lei; Fan, Yanhui; Song, You‐Qiang; Zee, Kwan-Yat; Tu, W; Jin, Lijian; Leung, W. Keung

doi:10.1002/jlb.4ma0720-698rr

Cited by 2 publications

(1 citation statement)

References 89 publications

(218 reference statements)

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“…Using MR approach, we show that elevated circulating concentrations of IL9 predispose individuals to the development of periodontitis. A previous meta-analysis assessing genetic polymorphisms of IL9 in Chinese non-smokers has suggested that IL9 does not have a causal relationship with periodontitis ( Zheng et al, 2020 ). We use MR to analyze the latest GWAS meta-analysis of the GLIDE Consortium, the largest sample size to date involving 17,353 clinically diagnosed cases and 28,210 controls ( Shungin et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of bidirectional relationships between circulating cytokines and periodontitis: Insights from a mendelian randomization analysis

Huang

et al. 2023

Front. Genet.

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Background: The purpose of this Mendelian randomization (MR) study was to assess the causal relationship between circulating cytokines and periodontitis.Materials and methods: Based on the aggregated statistics of the largest publicly available genome-wide association study (GWAS), we applied a bidirectional two-sample MR. MR analyses were conducted using Inverse variance weighted (IVW), Robust Adjusted Profile Score (RAPS), Maximum likelihood (ML), Weighted median and MR-Egger, and results obtained from IVW served as the primary outcome. Cochran Q test was used to test the heterogeneity. MR-Egger intercept test and MR polymorphism residual and outlier test (MR-PRESSO) were used for polymorphism analysis. Leave-one-out sensitivity and funnel plots were used for sensitivity analysis.Results: The IVW method indicated that interleukin 9 (IL9) had a positive causal relationship with periodontitis [odds ratio (OR) = 1.199, 95% confidence interval (CI) = 1.049–1.372, p = 0.008], and interleukin 17 (IL17) had a negative causal relationship with periodontitis (OR = 0.847, 95% CI = 0.735–0.976, p = 0.022). In bidirectional MR, periodontitis was not causally related to any of the cytokines in our study.Conclusion: Our findings provided evidence in support of potential causal associations between circulating IL9/IL17 and periodontitis.

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Section: Discussionmentioning

confidence: 99%

Assessment of bidirectional relationships between circulating cytokines and periodontitis: Insights from a mendelian randomization analysis

Huang

et al. 2023

Front. Genet.

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Susceptibility Polymorphism in the Promoter Region of IL-4 and IL-13 in Individuals with Periodontitis: A Systematic Review

Silva,

Longhi,

Caldeira

et al. 2024

Pesqui. Bras. Odontopediatria Clín. Integr.

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Th2 cell regulatory and effector molecules single nucleotide polymorphisms and periodontitis

Abstract: To investigate the association between T helper 2 (Th2) cell regulatory and effector molecules' genetic polymorphisms and periodontitis. Single nucleotide polymorphisms (SNPs) of 11 Th2 cell regulatory or effector molecules genes (CD28,

Cited by 2 publications

References 89 publications

Assessment of bidirectional relationships between circulating cytokines and periodontitis: Insights from a mendelian randomization analysis

Assessment of bidirectional relationships between circulating cytokines and periodontitis: Insights from a mendelian randomization analysis

Susceptibility Polymorphism in the Promoter Region of IL-4 and IL-13 in Individuals with Periodontitis: A Systematic Review

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