Thai Herbal Formulas Used for Wound Treatment: A Study of Their Antibacterial Potency, Anti-Inflammatory, Antioxidant, and Cytotoxicity Effects

Chusri, Sasitorn; Settharaksa, Sukanya; Chokpaisarn, Julalak; Limsuwan, Surasak; Voravuthikunchai, Supayang Piyawan

doi:10.1089/acm.2012.0625

Cited by 23 publications

(20 citation statements)

References 41 publications

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“…These include dexamethasone and mitomycin C [8]. Therefore, many clinicians have begun to focus on natural herb extracts for their curative effects and low cytotoxicity [37]. …”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Li¹,

Zeng

Yang

2016

Respiration

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Background: Recurrent airway granulation hyperplasia and scar formation make airway stenosis a clinical challenge. Therefore, a new approach for the treatment of airway stenosis is necessary. Objective: To explore the inhibitory effect of β-elemene on the proliferation of fibroblasts and airway granulation. Methods: In vivo: (1) study of the effect of local β-elemene injection by bronchoscopy. (2) During bronchoscopy, granulation tissues both before and after treatment were obtained. HE staining was performed and the result compared. In vitro: (1) human airway primary fibroblasts were purified and characterized. (2) Fibroblasts were treated with β-elemene and normal saline (NS) and then examined by optical and electron microscopy. (3) Fibroblasts treated with β-elemene or NS were assessed for viability by tetrazolium salt assay. (4) Apoptotic rates were determined by flow cytometry. Results: In vivo: (1) after local injection of β- elemene, airway granulation tissue was reduced. (2) Granulation tissue was found to have less edema, and fibroblasts turned into mature fiber cells. In vitro: (1) human airway primary fibroblasts were successfully purified and cultured. (2) Compared with the control group, fibroblasts of the experimental group became clumped, the plasma granules were increased, and some fibroblasts lost their nucleus and organelles. (3) Compared with the control group, reduction of cell viability was detected with increased concentrations of β-elemene. (4) With increased concentrations of β-elemene, apoptotic rates of the fibroblasts were raised compared with the control group. Conclusions: β-Elemene may induce apoptosis and necrosis of airway primary fibroblasts and inhibit the proliferation of fibroblasts and airway granulation. The results provide a new approach for the treatment of airway stenosis.

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“…These include dexamethasone and mitomycin C [8]. Therefore, many clinicians have begun to focus on natural herb extracts for their curative effects and low cytotoxicity [37]. …”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Li¹,

Zeng

Yang

2016

Respiration

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“…The medicinal plants were washed with distilled water, dried at 60°C overnight, and separately ground into fine powder. The formulation of YSMP consisting of 75 g of each herbal component was prepared as previously described (Chusri, Settharaksa et al 2013). Powders (300 g) of each medicinal plants and the recipe were then separately soaked in 95% ethanol (1500 mL) for 7 days at 25°C.…”

Section: Plant Materials and Preparation Of Extractsmentioning

confidence: 99%

“…Effects of the recipe extract and its effective constituents on biofilm formation of coagulase-positive staphylococci NPRC BCPS031 and the biofilm-positive strain, S. epidermidis ATCC 35984 were investigated (Chusri, Settharaksa et al 2013). The bacterial cultures were diluted 200-fold in TSBGlc, divided into 100-µL aliquots, and added into a flat-bottomed 96-well polystyrene microtiter plate (Nunc, Roskilde, Denmark).…”

Section: Anti-biofilm Propertymentioning

confidence: 99%

“…These results were similar to observations with biofilmforming strain of P. aeruginosa (Chusri, Sompetch et al 2013). Moreover, previous study has revealed the anti-biofilm potency of YSMP against the biofilm-positive strain, S. epidermidis ATCC 35984 (Chusri, Settharaksa et al 2013). Even though the anti-biofilm activity of YSMP and its components on mastitis-causing bacteria has never been investigated, curcumins and essential oil of C. longa displayed antibiofilm potencies on Streptococcus mutans (Lee et al 2011), Vibrio spp.…”

Section: Biofilm Inhibition Potency Of Ysmp and Its Componentsmentioning

confidence: 99%

“…An ethanol extract of YSMP had no cytotoxic effect and exhibited good anti-inflammatory and anti-oxidant activities. Its ethanol extract additionally possessed anti-biofilm activity against Staphylococcus epidermidis (Chusri, Settharaksa et al 2013) and Pseudomonas aeruginosa (Chusri, Sompetch et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial and anti-biofilm effects of a polyherbal formula and its constituents against coagulase-negative and -positive staphylococci isolated from bovine mastitis

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Areca catechu—From farm to food and biomedical applications

Salehi

Konovalov

Fru

et al. 2020

Phytotherapy Research

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The family Arecaceae includes 181 genera and 2,600 species with a high diversity in physical characteristics. Areca plants, commonly palms, which are able to grow in nearly every type of habitat, prefer tropical and subtropical climates. The most studied species Areca catechu L. contains phytochemicals as phenolics and alkaloids with biological properties. The phenolics are mainly distributed in roots followed by fresh unripe fruits, leaves, spikes, and veins, while the contents of alkaloids are in the order of roots, fresh unripe fruits, spikes, leaves, and veins. This species has been reputed to provide health effects on the cardiovascular, respiratory, nervous, metabolic, gastrointestinal, and reproductive systems. However, in many developing countries, quid from this species has been associated with side effects, which include the destruction of the teeth, impairment of oral hygiene, bronchial asthma, or oral cancer. Despite these side effects, which are also mentioned in this work, the present review collects the main results of biological properties of the phytochemicals in A. catechu. This study emphasizes the in vitro and in vivo antioxidant, antimicrobial, anticancer, and clinical effectiveness in humans. In this sense, A. catechu have demonstrated effectiveness in several reports through in vitro and in vivo experiments on disorders such as antimicrobial, antioxidant, or anticancer. Moreover, our findings demonstrate that this species presents clinical effectiveness on neurological disorders. Hence, A. catechu extracts could be used as a bioactive ingredient for functional food, nutraceuticals, or cosmeceuticals. However, further studies, especially extensive and comprehensive clinical trials, are recommended for the use of Areca in the treatment of diseases.

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Thai Herbal Formulas Used for Wound Treatment: A Study of Their Antibacterial Potency, Anti-Inflammatory, Antioxidant, and Cytotoxicity Effects

Cited by 23 publications

References 41 publications

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Inhibitory Effect of β-Elemene on Human Airway Granulation Tissue in vivo and in vitro

Antibacterial and anti-biofilm effects of a polyherbal formula and its constituents against coagulase-negative and -positive staphylococci isolated from bovine mastitis

Areca catechu—From farm to food and biomedical applications

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