Thai red rice extract provides liver protection in paracetamol-treated mice by restoring the glutathione system

Sinthorn, Wiladda; Chatuphonprasert, Waranya; Chulasiri, Malyn; Jarukamjorn, Kanokwan

doi:10.3109/13880209.2015.1079725

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…1d). The previous report also showed that Hom Dang rice bran extract can scavenge the superoxide anion and hydroxyl radicals due to its bioactive compounds contents 45 . These results well corroborate a previous finding that quercetin significantly suppresses the level of malondialdehyde, a naturally end product of lipid peroxidation and an oxidative stress biomarker, which could contribute to the protective effect on cell membranes 42 .…”

Section: Discussionmentioning

confidence: 95%

“…Furthermore, catechin present in the red rice bran (Table 2) also acts as a powerful hydrogen-donating radical scavenger of ROS and RNS and chelates divalent transition metal ions (Cu 2+ , Zn 2+ and Fe 2+ ), thereby preventing the Fe 2+ -induced formation of free radicals 58 . It also increases the expression of manganese superoxide dismutase SOD2 gene in Drosophila melanogaster and inhibits the signaling of transcription factor NF- κ B, leading to reductions in liver and kidney damage, and improvement of age-associated inflammation and oxidative stress in mice 45 . Thus, the evidence provided here and in other studies clearly support the antioxidative-assisted anti-aging effects of the pigmented rice extract and antioxidant compounds.…”

Section: Discussionmentioning

confidence: 99%

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Life-span extension by pigmented rice bran in the model yeast Saccharomyces cerevisiae

Sunthonkun

Palajai

Somboon

et al. 2019

Sci Rep

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Benefits of whole grains as dietary supplements and active ingredients in health products have been promoted. Despite being neglected as an agricultural byproduct of polished rice, pigmented rice bran has emerged as a promising source of natural anti-aging compounds. Indeed, the extract of red rice bran Hom Dang cultivar contained rich phenolic acids and flavonoids. It displayed high antioxidant activities in vitro and in vivo assays. Using yeast model, extract and bioactive compounds, quercetin and protocatechuic acid found in the rice bran pericarp, effectively reduced levels of intracellular reactive oxygen species (ROS), restored plasma membrane damages and prolonged life-span of pre-treated wild-yeast cells. Importantly, these molecules modulated life span-extension through a mechanism of ROS reduction that resembles to that operated under the highly conserved Tor1- and Sir2-dependent signaling pathways, with the human homologs TORC1 and SIRT1, respectively. The key longevity factors Sch9 and Rim15 kinases, Msn2/4 regulators and a novel transcription factor Asg1, the antioxidant enzymes superoxide dismutases and glutathione peroxidases played important role in mediating longevity. Yeast clearly provides an instrumental platform for rapid screening of compounds with anti-aging efficacies and advances knowledge in the molecular study of ageing.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Life-span extension by pigmented rice bran in the model yeast Saccharomyces cerevisiae

Sunthonkun

Palajai

Somboon

et al. 2019

Sci Rep

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“…The reaction was stopped by adding 4 N NaOH before measuring the absorbance at a wavelength of 505 nm. The ALT and AST levels were determined using pyruvate as a standard [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Imbalance of the antioxidative system by plumbagin and Plumbago indica L. extract induces hepatotoxicity in mice

Sukkasem¹,

Chatuphonprasert²,

Tatiya-aphiradee³

et al. 2016

J Intercult Ethnopharmacol

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Background/Aim:Plumbago indica (PI) L. and its active constituent, plumbagin, has been traditionally claimed for several pharmacological activities; however, there is little information regarding their toxicity. The present study aims to examine the effects of plumbagin and PI extract (PI) on hepatic histomorphology and antioxidative system in mice.Materials and Methods:Adult male intelligent character recognition mice were intragastrically administered plumbagin (1, 5, and 15 mg/kg/day) or PI (20, 200, and 1,000 mg/kg/day) consecutively for 14 days. Hepatic histomorphology was examined. Plasma alanine transaminase (ALT) and aspartate transaminase (AST) levels, hepatic lipid peroxidation, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, and the ratio of reduced to oxidized glutathione (GSH/GSSG) were determined.Results:Plumbagin and PI concentration-dependently induced hepatic injury based on histopathological changes via imbalance of antioxidative system. Plumbagin and PI significantly increased plasma ALT and AST levels, hepatic lipid peroxidation, and GPx activity but significantly decreased hepatic SOD and CAT activities. The GSH/GSSG ratio was significantly reduced by plumbagin.Conclusion:Plumbagin and PI caused hepatotoxic effects in the mice by unbalancing of the redox defense system. Therefore, plumbagin and PI-containing supplements should be used cautiously, especially when consumed in high quantities or for long periods.

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“…for 30 days ICR mice, 60 mg/kg p.o. for 30 days ↑GSH; ↓GSSH [109] Methanol extract of Adansonia digitata L. (Malvaceae) 200 mg/kg p.o. for 7 days Wistar rats,2 g/kg p.o.…”

Section: Targeting Mitochondrial Oxidative Stress and Dysfunction Formentioning

confidence: 99%

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

et al. 2018

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Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in many developed countries. Mitochondrial oxidative stress is considered to be the predominant cellular event in APAP-induced liver injury. Accordingly, N-acetyl cysteine, a known scavenger of reactive oxygen species (ROS), is recommended as an effective clinical antidote against APAP-induced acute liver injury (AILI) when it is given at an early phase; however, the narrow therapeutic window limits its use. Hence, the development of novel therapeutic approaches that can offer broadly protective effects against AILI is clearly needed. To this end, it is necessary to better understand the mechanisms of APAP hepatotoxicity. Up to now, in addition to mitochondrial oxidative stress, many other cellular processes, including phase I/phase II metabolism, endoplasmic reticulum stress, autophagy, sterile inflammation, microcirculatory dysfunction, and liver regeneration, have been identified to be involved in the pathogenesis of AILI, providing new targets for developing more effective therapeutic interventions against APAP-induced liver injury. In this review, we summarize intracellular and extracellular events involved in APAP hepatotoxicity, along with emphatic discussions on the possible therapeutic approaches targeting these different cellular events.

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Thai red rice extract provides liver protection in paracetamol-treated mice by restoring the glutathione system

Cited by 11 publications

References 31 publications

Life-span extension by pigmented rice bran in the model yeast Saccharomyces cerevisiae

Life-span extension by pigmented rice bran in the model yeast Saccharomyces cerevisiae

Imbalance of the antioxidative system by plumbagin and Plumbago indica L. extract induces hepatotoxicity in mice

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

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