2014
DOI: 10.1007/s00429-014-0921-7
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Thalamic alterations in preterm neonates and their relation to ventral striatum disturbances revealed by a combined shape and pose analysis

Abstract: Finding the neuroanatomical correlates of prematurity is vital to understanding which structures are affected, and design efficient prevention andtreatment strategy. Converging results reveal that thalamic abnormalities are important indicators of prematurity. However, little is known about the localization of the disturbance within the subnuclei of the thalamus, or on the association of altered thalamic development with other deep gray matter disturbances. Here, using brain structural magnetic resonance imagi… Show more

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Cited by 32 publications
(56 citation statements)
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References 89 publications
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“…Regional brain morphometric techniques included volumetric segmentation of total intracranial CSF, cortical gray matter, cortical white matter, deep gray nuclei, brainstem and cerebellum using a neonatal and infant brain segmentation age-specific atlas customized by our group. [3133]We further segmented total intracranial CSF into three compartments: supratentorial extra-axial CSF, infratentorial extra-axial CSF and intraventricular CSF.…”
Section: Methodsmentioning
confidence: 99%
“…Regional brain morphometric techniques included volumetric segmentation of total intracranial CSF, cortical gray matter, cortical white matter, deep gray nuclei, brainstem and cerebellum using a neonatal and infant brain segmentation age-specific atlas customized by our group. [3133]We further segmented total intracranial CSF into three compartments: supratentorial extra-axial CSF, infratentorial extra-axial CSF and intraventricular CSF.…”
Section: Methodsmentioning
confidence: 99%
“…The population-based template was calculated iteratively and then align to the subject's shape (Bossa et al, 2011a, Lao et al, 2014a, Lao et al, 2014b). For each structure, we computed a transformation matrix corresponding to the rotation, translation and scaling.…”
Section: Methodsmentioning
confidence: 99%
“…To obtain a regional correlation of pre-and post-RT tumor surfaces, GTV pre and GTV post were matched using surface-based constrained harmonic registration [14,15]. As such, shape changes were tracked within the structure-of-interest, excluding the influence of surrounding parenchyma [16]. For each surface vertex, a multivariate vector was formed using both the anatomic and metabolic components.…”
Section: Surface Measurement Generationmentioning
confidence: 99%
“…The anatomic component consisted of two geometrical features based on the same surface model: the normal direction, represented by the midline to surface radius , and the surface area, represented by the Jacobian of the transformation (J) from surface registration [16,17]. Two Jacobian derived metrics were used: the determinant of Jacobian (detJ) and the log-Euclidean projected deformation tensor (log JJ T ).…”
Section: Surface Measurement Generationmentioning
confidence: 99%
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