Thalamic nuclei degeneration in multiple sclerosis

Trufanov, A. G.; Бисага, Г Н; Skulyabin, D. I.; Temniy, A. V.; Poplyak, M. O.; Chakchir, Oleg B.; Efimtsev, A. Yu.; Tarumov, D.A.; Одинак, М. М.; Litvinenko, Igor

doi:10.1016/j.jocn.2021.05.043

Cited by 9 publications

(4 citation statements)

References 41 publications

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“…Deeper nuclei impairment, higher thalamic lesion volume and higher thalamic volume reduction was seen in SPMS compared with the RRMS group [ 38 , 51 , 68 ]. Baseline volume and the rate of annual volume loss of the ventral lateral nucleus were significant predicting factors of disease progression [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

“…Normalized thalamic volume and anterior thalamic radiation integrity were among the predictors of cognitive decline [ 77 , 79 ]. Both verbal and written parts of the SDMT test indicated moderate to strong correlations with the volume of thalamus nuclear groups [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…Thalamic volume change especially in the anterior, ventral anterior, ventral lateral and pulvinar nuclei inversely correlated with EDSS [50][51][52][53]. Furthermore, the EDSS was negatively associated with thalamic iron [54].…”

Section: Mri Markers Predicting the Disability Progressionmentioning

confidence: 91%

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Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies

Lomer,

Asalemi,

Saberi

et al. 2024

PLoS ONE

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Introduction Multiple Sclerosis (MS) is a chronic neurodegenerative disorder that affects the central nervous system (CNS) and results in progressive clinical disability and cognitive decline. Currently, there are no specific imaging parameters available for the prediction of longitudinal disability in MS patients. Magnetic resonance imaging (MRI) has linked imaging anomalies to clinical and cognitive deficits in MS. In this study, we aimed to evaluate the effectiveness of MRI in predicting disability, clinical progression, and cognitive decline in MS. Methods In this study, according to PRISMA guidelines, we comprehensively searched the Web of Science, PubMed, and Embase databases to identify pertinent articles that employed conventional MRI in the context of Relapsing-Remitting and progressive forms of MS. Following a rigorous screening process, studies that met the predefined inclusion criteria were selected for data extraction and evaluated for potential sources of bias. Results A total of 3028 records were retrieved from database searching. After a rigorous screening, 53 records met the criteria and were included in this study. Lesions and alterations in CNS structures like white matter, gray matter, corpus callosum, thalamus, and spinal cord, may be used to anticipate disability progression. Several prognostic factors associated with the progression of MS, including presence of cortical lesions, changes in gray matter volume, whole brain atrophy, the corpus callosum index, alterations in thalamic volume, and lesions or alterations in cross-sectional area of the spinal cord. For cognitive impairment in MS patients, reliable predictors include cortical gray matter volume, brain atrophy, lesion characteristics (T2-lesion load, temporal, frontal, and cerebellar lesions), white matter lesion volume, thalamic volume, and corpus callosum density. Conclusion This study indicates that MRI can be used to predict the cognitive decline, disability progression, and disease progression in MS patients over time.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies

Lomer,

Asalemi,

Saberi

et al. 2024

PLoS ONE

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“…Fully automatic surface-based MR-morphometry with FreeSurfer is the greatest tool for assessment of the cortical thicknesses and gray matter volumes in different brain areas ( Fischl, 2012 ). There are multiple studies on the usage of this method in patients with different neurologic and psychiatric conditions ( Schmaal et al, 2017 ; Trufanov et al, 2021 ). Despite that, the data regarding patients with moyamoya angiopathy is limited and controversial, because it is a rare disease.…”

Section: Introductionmentioning

confidence: 99%

Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy

et al. 2022

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BackgroundDespite it being known that chronic ischemia results in myelin damage and gray matter atrophy, data regarding patients with moyamoya angiopathy is limited. We hypothesized that chronic ischemia in moyamoya angiopathy leads to myelin damage, especially in anterior watershed regions, as well as cortical atrophy in these areas.Materials and methodsTwenty adult patients with moyamoya angiopathy and 17 age- and sex-matched healthy controls were evaluated using the T1w/T2w mapping method and surface-based MR-morphometry. The T1w/T2w signal intensity ratio, which reflects the white matter integrity, and the cortical thickness, were calculated in watershed regions and compared between the patients and controls. In the patients with moyamoya angiopathy, the correlations between these parameters and the Suzuki stage were also evaluated.ResultsThe regional T1w/T2w ratio values from centrum semiovale in patients with MMA were significantly lower than those in healthy controls (p < 0.05); there was also a downward trend in T1w/T2w ratio values from middle frontal gyrus white matter in patients compared with the controls (p < 0.1). The cortical thickness of the middle frontal gyrus was significantly lower in patients than in healthy controls (p < 0.05). There were negative correlations between the Suzuki stage and the T1w/T2w ratio values from the centrum semiovale and middle frontal white matter.ConclusionT1w/T2w mapping revealed that myelin damage exists in watershed regions in patients with moyamoya angiopathy, in association with cortical atrophy according to MR-morphometry. These changes were correlated with the disease stage.

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Brainstem and subcortical regions volume loss in patients with degenerative cervical myelopathy and its association with spinal cord compression severity

Filimonova,

Vasilenko,

Kubetsky

et al. 2023

Clinical Neurology and Neurosurgery

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Thalamic nuclei degeneration in multiple sclerosis

Cited by 9 publications

References 41 publications

Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies

Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies

Myelin damage and cortical atrophy in watershed regions in patients with moyamoya angiopathy

Brainstem and subcortical regions volume loss in patients with degenerative cervical myelopathy and its association with spinal cord compression severity

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