Thalassemia Prevalence and Status in Egypt

El‐Beshlawy, Amal; Kaddah, N; Rageb, L; Hussein, I. Y.; Mouktar, G; Moustafa, Ahmed S. Zaki; Elraouf, E; Hassaballa, N; Gaafar, TM; El-Sendiony, H

doi:10.1203/00006450-199905010-00132

Cited by 22 publications

(15 citation statements)

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“…It is a major health problem with a carrier rate is about 9-10% (El-Beshlawy et al, 1999;Hussein et al, 2007). Thalassemia are groups of genetic (inherited) blood disorders that share in common one feature, the defective production of hemoglobin, the protein that enables red blood cells to carry oxygen (and carbon dioxide).…”

Section: Introductionmentioning

confidence: 99%

The Clinical Significance of OPG/sRANKL Ratio in Thalassemia Patients Suffering from Osteopenia or Osteoporosis in Egyptian Patients

Salah

Atfy

Fathy

et al. 2010

Immunological Investigations

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Osteopenia and osteoporosis are considered major health problems in patients suffering from thalassemia due to increased life expectancy of those patients. Osteoprotegerin (OPG) and receptor activator of NF-kappa-B ligand (RANKL) have been recently implicated in the pathogenesis of various types of osteoporosis. The aim of this study is to evaluate the role of serum OPG/RANKL ratio in patients suffering from thalassemia complicated with osteoporosis. Serum OPG and RANKL were measured in thalassemia patients and 20 healthy control subjects, using ELISA methods. Stastistically, the results demonstrate lower OPG and OPG/RANKL ratio in patients suffering from thalassemia with documented osteopenia or osteoporosis in comparison with control group and patients suffering from thalassemia without osteopenia or osteoporosis. OPG/RANKL ratio could become a promising rapid and cheap screening marker for osteopenia or osteoporosis in patients suffering from thalassemia. Furthermore, OPG may become a therapeutic option in treatment of osteoporosis of various etiologies including thalassemia.

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Section: Introductionmentioning

confidence: 99%

The Clinical Significance of OPG/sRANKL Ratio in Thalassemia Patients Suffering from Osteopenia or Osteoporosis in Egyptian Patients

Salah

Atfy

Fathy

et al. 2010

Immunological Investigations

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“…It affects multiple organs and is associated with considerable morbidity and mortality. A carrier rate of 9-10.2% has been estimated among 1000 normal children selected at random from different geographical areas of Egypt [3]. b-Thalassemia is the most common form of chronic hemolytic anemia in Egypt (85.1%) [3].…”

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confidence: 99%

Study of thyroid function in Egyptian children with β-thalassemia major and β-thalassemia intermedia

Abdel-Razek

Abdelsalam²,

El-Sonbaty³

et al. 2013

Journal of the Egyptian Public Health Association

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“…It is the most common chronic hemolytic anemia in Egypt (85.1%), and its carrier rate has been estimated at 9-10.2% from an examination of 1000 normal random subjects from different geographic areas of the country [3].…”

Section: Epidemiology Of β-Thalassemiasmentioning

confidence: 99%

β-Thalassemia: Genotypes and Phenotypes

Hassan¹,

Badr²,

Safy³

et al. 2016

Epidemiology of Communicable and Non-Communicable Diseases - Attributes of Lifestyle and Nature on Humankind

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β-Thalassemias are extremely heterogeneous at the molecular level. More than 200 disease-causing mutations have been identified. The majority of mutations are single nucleotide substitutions. Rarely, β-thalassemia results from gross gene deletion. The degree of globin chain imbalance is determined by the nature of the mutation of the βgene. β 0 refers to the complete absence of production of β-globin on the affected allele. β + refers to alleles with some residual production of β-globin (around 10%). In β ++ , the reduction in β-globin production is very mild. The broad spectrum of β-thalassemia alleles can produce a wide spectrum of different β-thalassemia phenotypes. In this chapter, we review the molecular basis of the marked heterogeneity of the thalassemia syndromes or in other words the genotype-phenotype relationship in β-thalassemia.

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Thalassemia Prevalence and Status in Egypt

Cited by 22 publications

References 0 publications

The Clinical Significance of OPG/sRANKL Ratio in Thalassemia Patients Suffering from Osteopenia or Osteoporosis in Egyptian Patients

The Clinical Significance of OPG/sRANKL Ratio in Thalassemia Patients Suffering from Osteopenia or Osteoporosis in Egyptian Patients

Study of thyroid function in Egyptian children with β-thalassemia major and β-thalassemia intermedia

β-Thalassemia: Genotypes and Phenotypes

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