Thaliblastine

The synthesis of 2′,2′-bis-benzylisoquinolines and their cytostatic activities

“…This molecule was found to have significant biological activity against the Walker 256 carcinoma and antiproliferative activity on a broad range of human and animal cell lines in vitro and in vivo. 4,5 Initial clinical trails on this compound appeared encouraging, [4][5][6][7][8][9] however phase II clinical trials stopped after no antitumour effect was observed. 7,9 Inspired by the structure and biological activity of thalicarpine we became interested in the synthesis of the novel laudanosine dimers 2 and 3, in which two laudanosine units are linked via a C-2' biaryl bond, and an examination of their cytotoxicities on cancer cell lines.…”

Dimeric Aporphinoid, Alkaloids, III.

“…Owing to the cytotoxic and antitumor activities of thalicarpine [10] (= thaliblastine), several pharmacological studies on this alkaloid have been published (20,21,27,31). Cytotoxic activity has been also reported for the new thalifarazine [72] (35).…”

“…Cytotoxic activity has been also reported for the new thalifarazine [72] (35). A quantitative determination of thalicarpine [10] in drugs has been reported (10) and various syntheses have been reviewed (31). The biosyntheses of thalicarpine [10] (25), adiantifoline [16], and thalmelatidine [18] (30) in Thalictrum minus have been studied.…”