The 19F NMR spectra of some fluoroaryl mercurials and the electronic effect of mercury substituents

Kravtsov, D. N.; Kvasov, B. A.; Golovchenko, L. S.; Fedin, É. I.

doi:10.1016/s0022-328x(00)80669-5

Cited by 24 publications

(1 citation statement)

References 15 publications

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“…Mass spectra were recorded on a VG Instruments 70-SE spectrometer at the Georgia Institute of Technology, Atlanta, GA. Elemental analyses were performed by Atlantic Microlab, Norcross, GA. Unless otherwise stated, all reagent chemicals and solvents (including anhydrous 44,45 and S-(2-naphthylmethyl) thioacetimidate 39 were prepared according to the literature. Preparation of 2,5-Bis(4-nitrophenyl)furans 2.…”

Section: Methodsmentioning

confidence: 99%

Diguanidino and “Reversed” Diamidino 2,5-Diarylfurans as Antimicrobial Agents

et al. 2001

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Dicationic 2,5-bis(4-guanidinophenyl)furans 5a-5f, 2,5-bis[4-(arylimino)aminophenyl]furans 6a-6b and 6e-6k, and 2,5-bis[4-(alkylimino)aminophenyl]furans 6c-6d have been synthesized starting from 2,5-bis[tri-n-butylstannyl]furan. Thermal melting studies with poly dA*dT and the duplex oligomer d(CGCGAATTCGCG)2 demonstrated high DNA binding affinities for a number of the compounds. The binding affinities are highly dependent on structure and are significantly affected by substituents both on the phenyl rings of the 2,5-diphenylfuran nucleus and on the cationic centers. Of the 17 novel dicationic compounds synthesized, six (6a, 6b, 5b, 6f, 6h, 6i) exhibited MICs of 2 microg/mL or less versus Mycobacterium tuberculosis. Of the compounds screened against Candida albicans, three gave MICs of 2 microg/mL or less (5b, 6h, 6i), and two (5b, 6i) were fungicidal, unlike a standard antifungal drug fluconazole, which was fungistatic. In addition, one of the tested compounds (6i) exhibited a MIC of<1 microg/mL against Aspergillus fumigatus, while also being a fungicidal against this organism. Finally, when evaluated against an expanded fungal panel, compound 6h showed good activity against Cryptococcus neoformans and Rhizopus arrhizus.

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Section: Methodsmentioning

confidence: 99%