The 2D:4D index is associated with the development of excess body weight in adults, but not with the rate of weight loss following bariatric surgery

Iljin, Aleksandra; Antoszewski, Bogusław; Szewczyk, Tomasz; Sitek, Aneta

doi:10.1038/s41598-022-12306-1

Cited by 6 publications

(2 citation statements)

References 48 publications

(89 reference statements)

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“…Different studies have also shown an association (or lack of association) of several digit measures and ratios with child and adolescent obesity [49] or child body composition [50]. In adult populations, different studies showed that excessive body weight in men and women, and fat accumulation in the upper arms, thighs, and lower legs in women with obesity, are associated with increased prenatal estrogen exposure as measured through 2D:4D [51]. As some authors suggested, this relationship could be of relevance in the field of obesity prevention, as the 2D:4D index (especially of the right hand) may be a useful marker in the early prediction of the elevated risk of developing excessive body weight in humans, although other relevant factors such as eating habits and lifestyle must be taken into account [51].…”

Section: Discussionmentioning

confidence: 99%

An Exploratory Analysis on the 2D:4D Digit Ratio and Its Relationship with Social Responsiveness in Adults with Prader–Willi Syndrome

Gámez

Gómez

Fernández-Lafitte

et al. 2023

JCM

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Prader–Willi syndrome (PWS) is a genetic disorder produced by a lack of expression of paternally derived genes in the 15q11–13 region. Research has generally focused on its genetic and behavioral expression, but only a few studies have examined epigenetic influences. Prenatal testosterone or the maternal testosterone-to-estradiol ratio (MaTtEr) has been suggested to play an important role in the development of the ‘social brain’ during pregnancy. Some studies propose the 2D:4D digit ratio of the hand as an indirect MaTtEr measure. The relationship between social performance and MaTtEr has been studied in other neurodevelopmental conditions such as Autism Spectrum Disorder (ASD), but to our best knowledge, it has never been studied in PWS. Therefore, our study aims to clarify the possible existence of a relationship between social performance—as measured using the Social Responsiveness Scale (SRS)—and MaTtEr levels using the 2D:4D ratio. We found that, as a group, PWS individuals have shorter index and ring fingers than the control group, but no significant difference in the 2D:4D ratios. The 2D:4D ratio showed a correlation only with Restricted Interests and Repetitive Behavior Subscale, where a positive correlation only for male individuals with PWS was found. Considering only PWS with previous GH treatment during childhood/adolescence (PWS-GH), index and ring fingers did not show differences in length with the control group, but the 2D:4D ratio was significantly higher in the right or dominant hand compared to controls.

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Section: Discussionmentioning

confidence: 99%

An Exploratory Analysis on the 2D:4D Digit Ratio and Its Relationship with Social Responsiveness in Adults with Prader–Willi Syndrome

Gámez

Gómez

Fernández-Lafitte

et al. 2023

JCM

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“…The data collected on problem solving related to quality was tested using the oneshot case method, which later resulted in a quality and effective model. This development research was to improve the existing management model with a new management model which later be assessed for its implementation and effectiveness (Iljin et al, 2022;Lukin et al, 2019).…”

Section: Disseminatementioning

confidence: 99%

Development of Curriculum Management Models in the Addiction Science Study Program

Setiyaningrum

Basuki

Setyowati

2022

IJORER Int. J. Recent Educ. Res.

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Drug abuse among students is a worrying problem that can threaten the survival of nation. This study carried tesearch design for the development of the Four D model is a model to develop learning devices. This method and model were chosen to develop addiction science education management that required to conduct feasibility, product validity, and trial. The development model based on curriculum management development referred to 4D development model, and referred to two quality requirements, namely valid and effective. This research objectives are to develop of curriculum management model for addiction science study program at IOHC INA Mojokerto, East Jawa, Indonesia. The quality of the Addiction Education Management Curriculum based on the final results had met the criteria "Very Good", so that it was appropriate to be applied and implemented as a product of developing curriculum management models in the addiction science study program at IOHC INA Mojokerto, East Java. The implication of this research is development of this curriculum is much needed to help nursing institutions to be more competent in the field of addiction science.

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Prenatal exposure to air pollutants and the second to fourth digit ratio in adult women

Pruszkowska-Przybylska,

Kliś,

Flis

et al. 2024

Sci Rep

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The study aimed to analyse the association between the digit ratio in adult women and the degree of air pollution (suspended particulate matter, sulphur dioxide, nitric dioxide, benzene levels) in the place of residence of their mothers during pregnancy. The data was collected from female students in several Polish cities. Measurements were taken, and questionnaire data were collected. 2D:4D ratios were calculated for the left and the right hand. The ratio was analysed as a continuous variables. Air quality information was retrieved from reports by the Chief Inspectorate for Environmental Protection. Statistically significant differences both in right-and left-hand 2D:4D ratio were found for PM 10 and benzene. In addition, the right-hand 2D:4D differed significantly depending on PM 2.5 . The association between digit ratio and the complex air pollution index was also found. Poor air quality was associated with higher values of the ratio. Our results indicate that a high airborne pollutant level, especially suspended particulate matter, is associated with a higher digit ratio.

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The 2D:4D index is associated with the development of excess body weight in adults, but not with the rate of weight loss following bariatric surgery

Cited by 6 publications

References 48 publications

An Exploratory Analysis on the 2D:4D Digit Ratio and Its Relationship with Social Responsiveness in Adults with Prader–Willi Syndrome

An Exploratory Analysis on the 2D:4D Digit Ratio and Its Relationship with Social Responsiveness in Adults with Prader–Willi Syndrome

Development of Curriculum Management Models in the Addiction Science Study Program

Prenatal exposure to air pollutants and the second to fourth digit ratio in adult women

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