The −308 G/A polymorphism in the tumor necrosis factor-α gene is not associated with development and progression of rheumatoid arthritis in Argentinean patients

Aranda, Federico; Wingeyer, Silvia D. Perés; Schneeberger, Emilce Edith; Valerio, María del Carmen; Martin, E.; Pra, Fernando Dal; Correa, María de los Ángeles; Citera, Gustavo; Martínez, Liliana; Mannucci, Pablo; Remondino, Graciela; Larrañaga, Gabriela de

doi:10.1111/1756-185x.12343

Cited by 9 publications

(7 citation statements)

References 47 publications

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“…In our study, TNFa -308G>A was not associated with RA in Tunisians, in agreement with some [32,41], but not other studies, which reported an association of the (minor) TNFa -308A allele [31,42], and -308G allele [30,43] with RA susceptibility. Future studies with larger samples from different ethnic groups are needed to confirm or alternatively rule out the contribution of TNFa -308G>A polymorphism to RA pathogenesis.…”

Section: Discussionsupporting

confidence: 93%

“…While TNFa -308G>A variant was associated with an increased transcription of the activity of the TNFa gene [29], its association with RA susceptibility and/or severity is controversial [29,30,41]. In our study, TNFa -308G>A was not associated with RA in Tunisians, in agreement with some [32,41], but not other studies, which reported an association of the (minor) TNFa -308A allele [31,42], and -308G allele [30,43] with RA susceptibility.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Interleukin-1β, Interleukin1-Ra, Interleukin-10, and tumor necrosis factor-α polymorphisms in Tunisian patients with rheumatoid arthritis

Lagha

Zidi

Stayoussef

et al. 2015

Pathologie Biologie

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

Interleukin-1β, Interleukin1-Ra, Interleukin-10, and tumor necrosis factor-α polymorphisms in Tunisian patients with rheumatoid arthritis

Lagha

Zidi

Stayoussef

et al. 2015

Pathologie Biologie

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“…In Han Chinese population, susceptibility of RA increased in patients with TNF-α −308G allele, especially in the females, and the patients containing both HLA-DRB1*04 and TNF-α–308 GG genotype showed a significant increase in risk for RA regardless of their sex (Li et al 2015 ). On the other hand, in a cohort of Argentinean patients with RA, the −308A allele was neither associated with suscetibility to RA nor with the course and outcome of the disease (Aranda et al 2014 ). In addition, there was no significant association between −308 G/A polymorphism and RA risk in a cohort of Bulgarian population (Manolova et al 2014 ).…”

Section: Association Between Tnf-α Genetic Polymorphisms and Autoimmumentioning

confidence: 99%

TNF-α gene polymorphisms and expression

2016

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Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in the pathogenesis of several diseases. Its encoding gene is located in the short arm of chromosome 6 in the major histocompatibility complex class III region. Most of the TNF-α gene polymorphisms are located in its promoter region and they are thought to affect the susceptibility and/or severity of different human diseases. This review summarizes the data related to the association between TNF-α gene and its receptor polymorphisms, and the development of autoimmune diseases. Among these polymorphisms the −308G/A TNF-α promotor polymorphism has been associated several times with the the development of autoimmune diseases, however some discrepant results have been recorded. The other TNF-α gene polymorphisms had little or no association with autoimmune diseases. Current results about the molecules controlling TNF-α expression are also presented. The discrepancy between different records could be related partly to either the differences in the ethnic origin or number of the studied individuals, or the abundance and activation of other molecules that interact with the TNF-α promotor region or other elements.

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“…16 An increased serum concentration of TNFα is an independent predictor of cardiovascular disease 17 and is a marker for recurrent coronary events following a previous acute myocardial infarction. 18 This polymorphism is associated with several conditions, [19][20][21] including infection, asthma, 20 autoimmune disease, 21,22 , and immune-mediated diseases, such as rheumatoid arthritis. 22 The TNF-α-308 polymorphism is also considered to play a key pathogenic role in CAD.…”

Section: Introductionmentioning

confidence: 99%

“…This polymorphism is associated with several conditions, [19][20][21] including infection, asthma, 20 autoimmune disease, 21,22 , and immune-mediated diseases, such as rheumatoid arthritis. 22 The TNF-α-308 polymorphism is also considered to play a key pathogenic role in CAD.…”

mentioning

confidence: 99%

Association of tumor necrosis factor‐α ‐308 G/A gene polymorphism with coronary artery diseases: An evidence‐based study

Kazemi

Jamialahmadi

Avan

et al. 2017

Clinical Laboratory Analysis

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Background Coronary artery disease (CAD) is the leading cause of death worldwide and remains a major health problem, providing the rationale for identification of molecular markers for detection of individuals at high risk of developing CAD. Tumor necrosis factor‐α (TNF‐α) plays a crucial role in the pathogenesis of CAD. We have therefore explored the association of TNF‐α 308 (G/A) gene polymorphism in 903 individuals with/without CAD. Methods TNF‐α 308 gene polymorphism was analyzed in 903 subjects of whom 222 were healthy controls. Among the 681 patients who were investigated angiographically, 468 had ≧50% stenosis and 213 patients had <50% stenosis. Biochemical profiles (eg, triglycerides, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, fasting blood glucose, and CRP) were evaluated. Associations between TNF‐α genotypes with biochemical and anthropometric characteristics were determined. Results The frequencies of TNF‐α‐AA or AG genotypes were significantly lower in patients classified as CAD patients with ≥ or <50% obstruction in at least one coronary artery, compared to the control group. We observed that CAD patients with ≥50% stenosis and with AA genotype were associated with higher risk of CAD with OR of 3.56 (95%CI: 1.02‐12.41; P=.046) using multivariate analysis. Moreover, we found that TNF‐α‐308‐AA genotype was associated with blood pressure and CRP level in CAD patients, compared to the wild type‐genotype. Conclusion Our data showed an association of TNF‐α‐308G/A polymorphism with CAD patients with ≥50% obstruction, supporting the need for further investigations on the role of TNF‐α‐308G/A polymorphism with hypertension.

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The −308 G/A polymorphism in the tumor necrosis factor-α gene is not associated with development and progression of rheumatoid arthritis in Argentinean patients

Abstract: In this cohort of Argentinean patients with RA, the TNF2 allele was neither associated with susceptibility to the disease nor was it associated with the variables related to the course and outcome of the disease.

Cited by 9 publications

References 47 publications

Interleukin-1β, Interleukin1-Ra, Interleukin-10, and tumor necrosis factor-α polymorphisms in Tunisian patients with rheumatoid arthritis

Interleukin-1β, Interleukin1-Ra, Interleukin-10, and tumor necrosis factor-α polymorphisms in Tunisian patients with rheumatoid arthritis

TNF-α gene polymorphisms and expression

Association of tumor necrosis factor‐α ‐308 G/A gene polymorphism with coronary artery diseases: An evidence‐based study

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