2006
DOI: 10.1177/147323000603400108
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The 5-Hydroxytryptamine2A Receptor Antagonist Sarpogrelate Hydrochloride Inhibits Acute Platelet Aggregation in Injured Endothelium

Abstract: In this study, the effect of sarpogrelate hydrochloride, a 5-hydroxytryptamine 2A receptor antagonist, on platelet aggregation at the site of injured carotid artery endothelium was examined. The rat common carotid artery was clamped for 30 min to induce endothelial injury. Sarpogrelate hydrochloride was administered before and after the injury, and the effects were compared with those in rats receiving sham operation only and those receiving clipping injury but no sarpogrelate hydrochloride. The animals were k… Show more

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Cited by 6 publications
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