2006
DOI: 10.1007/s11103-005-5546-z
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The A and B Loci in Tobacco Regulate a Network of Stress Response Genes, Few of which are Associated with Nicotine Biosynthesis

Abstract: Nicotine biosynthesis in Nicotiana tabacum is under genetic control by the A and B loci. Plants containing semi-dominant mutations at both the A and B loci (i.e. aabb genotype) have lower nicotine levels, reduced nicotine biosynthetic enzyme activities, and reduced mRNA levels of the corresponding biosynthetic genes. The A and B loci therefore appear to be coordinate regulators of several nicotine biosynthetic genes and define a group of co-regulated genes called the A-B regulon. To investigate the composition… Show more

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Cited by 37 publications
(38 citation statements)
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“…A tobacco gene fragment with similarity to an Arabidopsis purine uptake permease 1 (AtPUP1) (29) was previously isolated during a transcriptional profiling screen for genes that are coordinately regulated by the A and B loci in N. tabacum (15). Plasmid pJGJ332 (GenBank accession no.…”
Section: Nup1 Was Coordinately Regulated With Other Nicotine Biosynthmentioning
confidence: 99%
See 2 more Smart Citations
“…A tobacco gene fragment with similarity to an Arabidopsis purine uptake permease 1 (AtPUP1) (29) was previously isolated during a transcriptional profiling screen for genes that are coordinately regulated by the A and B loci in N. tabacum (15). Plasmid pJGJ332 (GenBank accession no.…”
Section: Nup1 Was Coordinately Regulated With Other Nicotine Biosynthmentioning
confidence: 99%
“…Uptake of purines into yeast cells expressing the recombinant AtPUP1 transporter is inhibited 35% in the presence of nicotine, suggesting that nicotine might be partially recognized by AtPUP1 (29). Transcripts corresponding to the cDNA fragment in pJGJ332 increase in WT B21 root cultures (AABB genotype) treated with MeJA and are significantly reduced in mutant aabb roots (15). These mRNA expression patterns are characteristic of coordinated nicotine biosynthetic gene expression (8, 14-18, 32, 33).…”
Section: Nup1 Was Coordinately Regulated With Other Nicotine Biosynthmentioning
confidence: 99%
See 1 more Smart Citation
“…It is well known that plant secondary metabolites can accumulate in response to elicitor or signal molecules (Zhao et al 2005). The biosynthesis and regulatory pathways of tobacco pyridine alkaloids form a well-studied group (Katoh and Hashimoto 2004;Kidd et al 2006), and the alkaloids are known to accumulate through a jasmonic acid-mediated response after herbivore attacks (Keinanen et al 2001;Kidd et al 2006). Here, we report for the first time that AMF components either from sterilized DS or from exudates formed during the spore germination process are able to alter tobacco alkaloid biosynthesis and accumulation.…”
Section: Discussionmentioning
confidence: 79%
“…For example, despite the changes caused in the nicotine content in tobacco plants exposed to AMF elicitors, it appears that tobacco displays different behaviors depending on the stimuli perceived and the location in the plant. In contrast to the increase of nicotine in leaves of Nicotiana species attacked by herbivores (Keinanen et al 2001;Kidd et al 2006), infection with Phytophthora nicotianae causes a reduction of the leaf alkaloid content (Iba´n˜ez et al 2010). …”
mentioning
confidence: 99%