The Abdominal Adipofascial Flap

Yazici, Ilker; Siemionow, Maria

doi:10.1097/sap.0b013e31814da751

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…9 These flaps were used for varying focuses of research successfully, but all require a certain degree of microsurgical including vessel dissections and/or ligations. 6,8,9,[14][15][16] Versatile use of adipofascial flaps in experimental research led us to seek a more accessible alternative demanding less time and surgical effort, which not only benefits the researcher, but also the animal. Short operative time decreases the amounts of anesthetic agents and thus undesired loss of subjects can be avoided.…”

Section: Discussionmentioning

confidence: 99%

“…In the scarce literature, currently available adipofascial flap models include epigastric, groin, and Rubens flaps based on the superficial epigastric, superficial circumflex iliac, and deep circumflex iliac vessels, respectively 9 . These flaps were used for varying focuses of research successfully, but all require a certain degree of microsurgical technique, including vessel dissections and/or ligations 6,8,9,14–16 . Versatile use of adipofascial flaps in experimental research led us to seek a more accessible alternative demanding less time and surgical effort, which not only benefits the researcher, but also the animal.…”

Section: Discussionmentioning

confidence: 99%

“…Although many myocutaneous and composite animal flap models were described previously, pedicled adipofascial flap models are mostly limited to the ones based on the epigastric vessels. [6][7][8][9] The purpose of this study is to define a flap containing only adipose tissue, which can be dissected quickly without high surgical expertise and can be used in the reconstruction of abdominal, thoracic, and lower extremity defects or in studies focusing on adipofascial flap or pedicled flap physiology.…”

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confidence: 99%

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Superior Epididymal Artery-Based Paraepididymal Adipofascial Flap

et al. 2023

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Background Flap surgery is widely performed in reconstructive surgery. Experimental research is vital to improve flap viability. However, the number of flap models for animals is still limited. In this study, we define a new adipofascial flap in rats that can be used to investigate pedicled flap and/or adipofascial flap physiology. Methods Eight Wistar male rats were used. Under deep anesthesia, paraepididymal adipofascial flaps were harvested. Flap perfusion was assessed using a near-infrared fluorescence imaging system. The length of the flap and the diameter of the flap pedicle were measured. Results All animals (n = 8) had sufficient sizes of paraepididymal fat pad, and no animals were lost. The only postoperative complication was testicular hematoma, which was observed in 2 animals. The maximum length of the harvested paraepididymal adipofascial flap was 9.7 cm with a mean of 6.6 cm. The maximum width of the flap was 3.3 cm with a mean of 2.6 cm. The mean pedicle diameter of the paraepididymal adipofascial flap was 1.1 mm. Near-infrared fluorescence imaging revealed adequate perfusion in all flaps. Conclusions The number of reported adipofascial flap models in animals is low, and they are mostly limited to flaps based on epigastric vessels. Superior epididymal artery-based paraepididymal adipofascial flap can be used as a pedicled flap model for studies focusing on adipofascial and/or pedicled flap physiology. Uncomplicated surgical technique and short operative time make this flap a valuable alternative to other flap models.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Superior Epididymal Artery-Based Paraepididymal Adipofascial Flap

et al. 2023

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Denervation leads to volume regression in breast cancer

Kappos

Engels

Tremp

et al. 2018

Journal of Plastic, Reconstructive & Aesthetic Surgery

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The nervous system plays a key role in controlling the dynamic functions of multicellular complex organisms. Although peripheral nerves are supposed to play a pivotal role in tumor growth and dissemination, little experimental evidence exists to date. We assessed the effect of denervation on breast cancer growth by magnetic resonance imaging (MRI) in rats. Human breast cancer cells were implanted into adipofascial flaps with intact or surgically excised supplying nerve. Tumor volumes were measured 2 and 8 weeks after implantation by in vivo MRI. Results were validated by histology. Postoperative tumor volumes at 2 and 8 weeks were reduced by 76% (95% CI: 22-93%) in the denervated groups. Tumor area as determined histologically was reduced by 70% (95% CI: 60-78%). Thus, peripheral denervation may be an effective surgical approach for the palliative treatment of locally progressing or uncontrollable breast cancer.

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The Abdominal Adipofascial Flap

Cited by 2 publications

References 17 publications

Superior Epididymal Artery-Based Paraepididymal Adipofascial Flap

Superior Epididymal Artery-Based Paraepididymal Adipofascial Flap

Denervation leads to volume regression in breast cancer

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