The Aberrant Immune System in Atopic Dermatitis

Marsella, Rosanna

doi:10.1002/9781118738818.ch3

Cited by 2 publications

(2 citation statements)

References 76 publications

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“…The pathogenesis of atopic dermatitis (AD) is complex and multifactorial. There is evidence an impaired skin barrier plays a role in the pathogenesis (Marsella 2014 ) which may include stratum corneum (SC) lipid abnormalities (Inman et al 2001 ; Stahl et al 2001; Olivry 2011 ; van Smeden et al 2011 ; Miller et al 2013 ; Nishifuji 2014 ). The skin barrier is thought to be provided predominantly by the outermost layer of the epidermis, the SC (Olivry 2011 ; Miller et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

An explorative study comparing skin surface lipids in the West Highland white terrier dog with and without atopic dermatitis

Orbell¹,

Cave

Parry

et al. 2022

Veterinary Quarterly

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Background The skin barrier is important in the pathogenesis of atopic dermatitis and stratum corneum lipids have a critical role. Skin surface lipids have been largely overlooked but also contribute to barrier function. An untargeted approach was used to compare the skin surface lipids from atopic and non-atopic West Highland White terrier dogs (WHWT). Objectives The primary hypothesis was that a difference in the lipidome would exist. The secondary hypothesis was that affected and unaffected skin lipids would differ. Animals and methods This prospective, cross-sectional, case-controlled study included thirty-nine privately owned WHWTs. Dogs were assigned to one of four disease status groups based on strict criteria. Samples for lipid analysis were collected from the skin surface of unaffected and affected sites. Lipid analysis was by untargeted liquid chromatography/mass spectrometry and utilised lipid identification software packages. Principle component analysis (PCA) and partial least-squares discriminant analysis (sPLS-DA) statistical methods analysed the association between the relative lipid abundance and disease status and affected and unaffected skin. Results Samples for lipid analysis found 421 lipid soluble features of which ten lipids were positively identified. Statistical analysis could not distinguish between non-atopic and atopic dogs but did reveal a statistically significant difference in the lipid profiles from affected and non-affected skin irrespective of disease status. Conclusions A large array of unidentified lipids from the skin surface were found with a difference between affected and unaffected skin unrelated to disease status. Investigation into the lipidome of the skin surface is an emerging area of research with clinical and therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

An explorative study comparing skin surface lipids in the West Highland white terrier dog with and without atopic dermatitis

Orbell¹,

Cave

Parry

et al. 2022

Veterinary Quarterly

View full text Add to dashboard Cite

show abstract

“…The pathogenesis of atopic dermatitis (AD) is complex and multifactorial. There is evidence an impaired skin barrier plays a role in the pathogenesis [1], which may include stratum corneum (SC) lipid abnormalities [2,3,4,5,6,7]. The skin barrier is thought to be provided predominantly by the outermost layer of the epidermis, the SC [2,3].…”

Section: Introductionmentioning

confidence: 99%

An untargeted investigation into the skin surface lipidome in the West Highland white terrier dog, with and without atopic dermatitis

Orbell

Cave

Parry

et al. 2020

Preprint

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Background – The skin barrier is important in the pathogenesis of atopic dermatitis and stratum corneum lipids have a critical role. Skin surface lipids have been largely overlooked but also contribute to barrier function. An untargeted approach was used to compare the skin surface lipids from atopic and non-atopic West Highland White terrier dogs. The primary hypothesis was that a difference in the lipidome of atopic and non-atopic dogs would be found and the secondary hypothesis was that affected and unaffected skin would differ in lipid profile.Results – Thirty-nine dogs were classified into one of four disease status groups based on strict criteria. Samples for lipid analysis were collected from affected and unaffected skin, and liquid chromatography/mass spectrometry found 421 lipid soluble features. Ten lipids were positively identified. Statistical analysis could not distinguish between non-atopic and atopic dogs. Partial least squares-discriminant analysis revealed a difference in the lipid profiles from affected and non-affected skin irrespective of disease status. Conclusions – An untargeted approach found a large array of unidentified lipids from the skin surface. There was a difference in the lipidome between affected and unaffected skin that was not related to disease status. Investigation into the lipidome of the skin surface in health and disease is an emerging area of research which could have clinical and therapeutic applications.

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The Aberrant Immune System in Atopic Dermatitis

Cited by 2 publications

References 76 publications

An explorative study comparing skin surface lipids in the West Highland white terrier dog with and without atopic dermatitis

An explorative study comparing skin surface lipids in the West Highland white terrier dog with and without atopic dermatitis

An untargeted investigation into the skin surface lipidome in the West Highland white terrier dog, with and without atopic dermatitis

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