The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone

Ulrich, D; Rietbergen, Bert van; Laib, Andres; Rüegsegger, P.

doi:10.1016/s8756-3282(99)00098-8

Cited by 634 publications

(425 citation statements)

References 27 publications

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“…Even if significant correlations between architectural and mechanical properties are published in the literature, the fact that 3D standard parameters, 3D connectivity or 3D fractal dimension, can improve the assessment of the compressive strength by the bone volume fraction has not been well demonstrated. Kabel et al [60] concluded that the integration of the connectivity density in the multiple correlation, marginally improves the correlation between the mechanical stiffness and the bone volume fraction, whereas Ulrich et al [61] concluded there was a real improvement. In other respects, the fabric tensor built from MIL parameters has largely been used with the bone volume fraction to estimate the elastic properties of cancellous bone [34,62].…”

Section: Discussionmentioning

confidence: 99%

Relationship between compressive properties of human os calcis cancellous bone and microarchitecture assessed from 2D and 3D synchrotron microtomography

Follet

Bruyère-Garnier

Peyrin

et al. 2005

Bone

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The aim of this study was to determine the contribution of 2D and 3D microarchitectural characteristics in the assessment of the mechanical strength of os calcis cancellous bone. A sample of cancellous bone was removed in a medio-lateral direction from the posterior body of calcaneus, taken at autopsy in 17 subjects aged 61-91 years. The sample was first used for the assessment of morphological parameters from 2D morphometry and 3D synchrotron microtomography (ACT) (spatial resolution = 10 Am). The 2D morphometry was obtained from three slices extracted from the 3D ACT images. Very good concordance was shown between 3D ACT slices and the corresponding physical histologic slices. In 2D, the standard histomorphometric parameters, fractal dimension, mean intercept length, and connectivity were computed. In 3D, histomorphometric parameters were computed using both the 3D mean intercept length method and model-independent techniques. The 3D fractal dimension and the 3D connectivity, assessed by Euler density, were also evaluated. The cubic samples were subjected to elastic compressive tests in three orthogonal directions (X, Y, Z) close to the main natural trabecular network directions. A test was performed until collapse of trabecular network in the main direction (Z). The mechanical properties were significantly correlated to most morphological parameters resulting from 2D and 3D analysis. In 2D, the correlation between the mechanical strength and bone volume/tissue volume was not significantly improved by adding structural parameters or connectivity parameter (nodes number/tissue volume). In 3D, one architectural parameter (the trabecular thickness, Tb.Th) permitted to improve the estimation of the compressive strength from the bone volume/tissue volume alone. However, this improvement was minor since the correlation with the BV/TV alone was high (r = 0.96). In conclusion, which is in agreement with the statistic's rules, we found, in this study, that the determination of the os calcis bone compressive strength using the 3D bone volume fraction cannot be improved by adding 3D architectural parameters.

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Section: Discussionmentioning

confidence: 99%

Relationship between compressive properties of human os calcis cancellous bone and microarchitecture assessed from 2D and 3D synchrotron microtomography

Follet

Bruyère-Garnier

Peyrin

et al. 2005

Bone

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“…The decision about a possible candidate status was thus hindered. However, in 7 of the 10 remaining regions, possible candidate genes could be identified: WBSCR17 (International Mouse Phenotyping Consortium), SRSF7 (International Mouse Phenotyping Consortium), USP28 (Valero et al, 2001), NNMT (Trammell and Brenner, 2015), ZBED6 (Clark et al, 2015;Markljung et al, 2009), NMNAT2 (Hicks et al, 2012), ABHD6 (Thomas et al, 2013), PDHB (Sasaki et al, 2006;Serao et al, 2011) and PSMA2 (Sakamoto et al, 2009). These are listed in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…However, since similar values for estimation of T scores based on BMD are missing for pigs, this hypothesis has not been verified yet. Based on the fact that the mechanical properties of bones are determined by BMD and bone microarchitecture, another shortcoming of the DXA method is its inability to differentiate between cortical and trabecular bone (Ulrich et al, 1999;Sornay-Rendu et al, 2006). Moreover, it has already been shown that increased body fat causes deviations in BMD measurements by DXA scans and, to a much lesser extent, also in quantitative computed tomography (QCT) (Yu et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Genome-wide QTL mapping results for regional DXA body composition and bone mineral density traits in pigs

Bernau¹,

Kremer-Rücker

Međugorac³

et al. 2017

Arch. Anim. Breed.

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Abstract. In a previous study, genome-wide mapping of quantitative trait loci (QTL) for five body composition traits, three bone mineral traits and live weight was performed using whole-body dual-energy X-ray absorptiometry (DXA) data. Since QTL for bone mineral traits were rare, the current study aimed to clarify whether the mapping results were influenced by the analysed body regions. Thus, the same material (551 pigs) and methods as in the whole-body QTL mapping study were used. However, for evaluation of the DXA scans, we manually defined two body regions: (i) from the last ribs to the pelvis (A) and (ii) including the pelvis and the hind limbs (P). Since live weight was not affected by the regional analysis, it was omitted from the QTL mapping design.Our results show an overall high consistency of mapping results especially for body composition traits. Two thirds of the initial whole-body QTL are significant for both A and P. Possible causes for the still low number of bone mineral QTL and the lower consistency found for these traits are discussed. For body composition traits, the data presented here show high genome-wide Pearson correlations between mapping results that are based on DXA scans with the time-saving "whole-body standard setting" and mapping results for DXA data that were obtained by time-consuming manual definition of the regions of interest. However, our results also suggest that whole-body or regional DXA scans might generally be less suitable for mapping of bone mineral traits in pigs. An analysis of single reference bones could be more useful.

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“…D'autres, comme Hildebrand et al [26], ont utilisé comme élément structurant une sphère pour une mesure directe de l'épaisseur des travées et de l'espace intertravées. Le paramètre Tb.N dérivé de l'inverse de la distance des axes médians de la structure trabéculaire est souvent utilisé [27]. Les autres paramètres peuvent être calculés à l'aide de modèles en plaque ou en poutre à partir de ces méthodes d'évaluation directe [24].…”

Section: Les Méthodes De Mesure Les Analyses Morphologiquesunclassified

Méthodes d’évaluation de la microarchitecture de l’os trabéculaire humain

Chappard

2012

Med Sci (Paris)

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The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone

Cited by 634 publications

References 27 publications

Relationship between compressive properties of human os calcis cancellous bone and microarchitecture assessed from 2D and 3D synchrotron microtomography

Relationship between compressive properties of human os calcis cancellous bone and microarchitecture assessed from 2D and 3D synchrotron microtomography

Genome-wide QTL mapping results for regional DXA body composition and bone mineral density traits in pigs

Méthodes d’évaluation de la microarchitecture de l’os trabéculaire humain

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