The Absorption of Lactic Acid from the Reticulo-Rumen of the Sheep

Williams, V. J.; Mackenzie, D. D. S.

doi:10.1071/bi9650917

Cited by 59 publications

(23 citation statements)

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“…Umesaki et al [27] concluded that the rates of absorption of lactic and succinic acids in the rat colon were about one hundredth of the SCFAs absorption. In other reports, it was noted that the mean absorption rates of lactic acid were about 8% [32] and 10% [1] of that of SCFAs.…”

Section: Discussionmentioning

confidence: 99%

Effect of Sugar Alcohols on Gut Function and Body Composition in Normal and Cecectomized Rats

et al. 2004

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Abstract:The effects of two sugar alcohols on feed utilization, digesta retention, gut fermentation and serum lipid profiles were compared in normal and cecectomized rats to examine the possibility of the cecectomized rat as an experimental animal with relevance to humans. Semi-purified diets containing no sugar alcohol, 7% sorbitol or 7% lactitol were fed to normal and cecectomized rats for 16 days. The digestibility of the crude fat and the compositions of the carcass dry matter and crude fat were significantly decreased by feeding sugar alcohols in both groups, but the effects were relatively higher in the cecectomized rats than in the normal rats. Diarrhea, faster transit times and shorter retention times of digesta were noted in the cecectomized rats fed sugar alcohols, while the inverse results were observed in the normal rats fed similar diets. The concentration of cecal organic acids was increased in the normal rats, whereas the concentration of colonic organic acids was decreased in the cecectomized rats fed sugar alcohols, compared with their corresponding control groups. The concentration of serum total cholesterol was decreased in both the normal and cecectomized rats fed diets containing sugar alcohols. The tendencies for diarrhea, faster digesta transit and reduced body fat induced by the fermentable materials in the cecectomized rat have good relevance to the parallel effects of fermentable materials in humans, suggesting the possibility of using the cecectomized rat as a model to study some of the physiological effects of sugar alcohols in humans.

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Section: Discussionmentioning

confidence: 99%

Effect of Sugar Alcohols on Gut Function and Body Composition in Normal and Cecectomized Rats

et al. 2004

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“…Lactic acid is a much stronger acid (pK 3 8) than the VFAs (pK 4-7-48) and the pH must be correspondingly lower, or the total acid concentration much higher in order to achieve a similar concentration of undissociated acid, for it is the latter value, rather than the total acid concentration that is important for the absorption (Williams & Mackenzie, 1965), excitation of acid-sensitive receptors (Leek & Harding, 1975) and inhibition of motility (Upton et al 1976). Due to the corrosive effect of lactic acid (Dunlop & Hammond, 1965;Ahrens, 1967) infusions of lactic acid were performed only once in any animal, as the last experiment, and in only two cases was infusion continued until abolition of motility occurred.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of reticulo‐ruminal motility by volatile fatty acids and lactic acid in sheep.

Gregory¹

1987

The Journal of Physiology

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SUMMARY1. A study was made of the influence on reticulo-ruminal motility, recorded by electromyography, of ruminal infusions of volatile fatty acids (VFAs) and lactic acid in twenty-four sheep maintained by intragastric infusion of a complete liquid diet, in three sheep fed grass pellets, and in nine chronically vagotomized sheep; abomasal and duodenal infusions of VFA and lactic acid were tested in five sheep fed grass pellets.2. Ruminal infusions of VFAs and lactic acid progressively inhibited the amplitude of the reticulo-ruminal contractions. In many experiments there was no effect on contraction frequency until the cessation of all reticulo-ruminal contractions at which point the maximal concentration of VFA recorded in the abomasum was 28 mm, and that of lactic acid was 20 mM.3. The concentrations of undissociated VFAs causing cessation of reticulo-ruminal contractions in the vagus-intact sheep were very similar to the concentrations causing abolition of the organized intrinsic motility of the chronically vagotomized sheep.4. The inhibition of reticulo-ruminal motility with ruminal infusions of mixtures of VFAs and of lactic acid together with VFAs could largely be explained by the sum of the effects of the individual acids present.5. Abomasal infusion of VFA or lactic acid inhibited the amplitude of ruminal, especially primary ruminal, contractions at concentrations of undissociated acid of 60 mm and above and increased the frequency of reticulum and primary ruminal contractions at about 80 mM.6. Duodenal infusion of VFAs and lactic acid (100 mm, 5 ml/min) strongly inhibited abomasal motility without affecting reticulo-ruminal motility, and at a higher rate (100 mm, 10 ml/min) abolished motility and inhibited both the amplitude and frequency of reticulo-ruminal contractions.7. It is concluded that the initial inhibition of reticulo-ruminal motility in ruminal acidosis is unlikely to involve any significant influence from duodenal, or abomasal receptors. The final cessation of reticulo-ruminal motility with ruminal acidosis could involve local effects of VFAs in the reticulo-rumen as well as through excitation of acid-sensitive reticulo-ruminal receptors.

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“…For the ten trials absorp tion rates of total VFA expressed as mmol/h per kg body weight averaged 3.11 with a range of 1.34-4.84. These results and especially those of trials 6 and 8 obtained with test solutions containing 75mmol/l total VFA at pH 6.0 are similar to the rates reported by Williams & Mackenzie (1965 Leng & Brett (1966) and Leng & Leonard (1965) determined ruminai VFA production rates in fed sheep by isotope dilution techniques. Production rates in mmol/h per kg body weight calculated from their results are comparable to the absorption rates observed in the present study, but generally tend to be somewhat higher, especially the production rates for acetate.…”

Section: Discussionsupporting

confidence: 76%

“…Relative absorption rates calculated from his data also indicated that the marked differences in the individual rates at which acetic, propionic and butyric acids were absorbed at pH 4 tended to de crease as the pH of the VFA solutions was raised to 7.8. This trend confirms the observation by Williams & Mackenzie (1965).…”

Section: Review Of Literaturesupporting

confidence: 82%

“…Danielli, Hitchcock, Marshall & Phillipson (1945) re ported this order to be reversed at alkaline pH in the rumen. Williams & Mackenzie (1965) found that the relative rates of absorption of acetate, propionate and butyrate were in the generally accepted order at pH 5, but that the relative rates were about equal at pH 7.5. Aafjes (1967) re ported VFA absorption from the rumen of cows at pH values of about 4, 5, 6, 7 and 7.8.…”

Section: Review Of Literaturementioning

confidence: 99%

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The extent of metabolism of propionate and butyrate during absorption from the bovine ruminoreticulum

Weigand

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The Absorption of Lactic Acid from the Reticulo-Rumen of the Sheep

Cited by 59 publications

References 10 publications

Effect of Sugar Alcohols on Gut Function and Body Composition in Normal and Cecectomized Rats

Effect of Sugar Alcohols on Gut Function and Body Composition in Normal and Cecectomized Rats

Inhibition of reticulo‐ruminal motility by volatile fatty acids and lactic acid in sheep.

The extent of metabolism of propionate and butyrate during absorption from the bovine ruminoreticulum

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