The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer

Shou, Wang; Igawa, Kazuyo; Ogawara, Ryo; Suda, M.; Hamano, Tsuyoshi; Ibaragi, Soichiro; Hanafusa, Tadashi; Yasuaki, Ichikawa; Sasaki, Akira

doi:10.1016/j.apradiso.2020.109271

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…First, the boron concentration of 3D cancer model was measured. The cancer model administered with boron (Borofaran, Stella Pharma, Osaka, Japan) for 2 h was cleaned with PBS twice and heated after being treated with HNO 3 , measured by Inductively Coupled Plasma-Mass Spectrometer (ICP-MS, Agilent7500cx, Agilent Technologies, Tokyo, Japan) [ 13 ]. Subsequently, the neutron fluence at the tumor area and normal area in the 3D oral cancer model was measured by activation method using gold foil at Kyoto University Research Reactor (KUR) [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Development of the Follow-Up Human 3D Oral Cancer Model in Cancer Treatment

Igawa

Izumi

Sakurai

2023

BioTech

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As function preservation cancer therapy, targeted radiation therapies have been developed for the quality of life of cancer patients. However, preclinical animal studies evaluating the safety and efficacy of targeted radiation therapy is challenging from the viewpoints of animal welfare and animal protection, as well as the management of animal in radiation-controlled areas under the regulations. We fabricated the human 3D oral cancer model that considers the time axis of the follow up in cancer treatment. Therefore, in this study, the 3D model with human oral cancer cells and normal oral fibroblasts was treated based on clinical protocol. After cancer treatment, the histological findings of the 3D oral cancer model indicated the clinical correlation between tumor response and surrounding normal tissue. This 3D model has potential as a tool for preclinical studies alternative to animal studies.

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Section: Methodsmentioning

confidence: 99%

Development of the Follow-Up Human 3D Oral Cancer Model in Cancer Treatment

Igawa

Izumi

Sakurai

2023

BioTech

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“…The development of accelerator-based neutron sources with effective beam intensity for BNCT allows the installation of BNCT facilities in situ, overcoming one of the major obstacles for the bench-to-bedside transition of the BNCT, i.e., access to a nuclear reactor in the hospital where patients would undergo the treatment [13][14][15]. Alternative radiation sources, such as X-rays, have also been employed in attempts of generating novel therapeutic strategies for boron-based radiation therapy [16].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Application of Carboranes for Boron Neutron Capture Therapy (BNCT): Structure, Formulation and Analytical Methods for Detection

Marforio,

Carboni,

Calvaresi

2023

Cancers

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Carboranes have emerged as one of the most promising boron agents in boron neutron capture therapy (BNCT). In this context, in vivo studies are particularly relevant, since they provide qualitative and quantitative information about the biodistribution of these molecules, which is of the utmost importance to determine the efficacy of BNCT, defining their localization and (bio)accumulation, as well as their pharmacokinetics and pharmacodynamics. First, we gathered a detailed list of the carboranes used for in vivo studies, considering the synthesis of carborane derivatives or the use of delivery system such as liposomes, micelles and nanoparticles. Then, the formulation employed and the cancer model used in each of these studies were identified. Finally, we examined the analytical aspects concerning carborane detection, identifying the main methodologies applied in the literature for ex vivo and in vivo analysis. The present work aims to identify the current strengths and weakness of the use of carboranes in BNCT, establishing the bottlenecks and the best strategies for future applications.

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