The ACDC Pilot Trial: Targeting the Anterior Cingulate by Double Cone Coil rTMS for the Treatment of Depression

Kreuzer, Peter; Schecklmann, Martin; Lehner, Astrid; Wetter, Thomas C.; Poeppl, Timm B.; Rupprecht, Rainer; Ridder, Dirk De; Landgrebe, Michael; Langguth, Berthold

doi:10.1016/j.brs.2014.11.014

Cited by 59 publications

(61 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The superiority of 10 Hz F8‐TMS over the left DLPFC in relation to sham‐TMS in treating TRD with regard to response (30.6% vs. 6.1%, respectively) and remission (20% vs. 3%, respectively) had been documented in previous trials . However, the comparison among DC‐TMS, F8‐TMS, and sham‐TMS showed that the double‐cone coil method yielded greater response (46.1% vs. 20% vs. 25%, respectively) and remission (38.4% vs. 26.6% vs. 25%, respectively) rates in treating depression . Prominent sleep pattern alterations, low refractoriness and short duration of symptoms are considered predictors of a good antidepressant response with traditional TMS .…”

Section: Discussionmentioning

confidence: 99%

Use of a Double-Cone Coil in Transcranial Magnetic Stimulation for Depression Treatment

Monteiro

Cantilino

2019

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Use of a Double-Cone Coil in Transcranial Magnetic Stimulation for Depression Treatment

Monteiro

Cantilino

2019

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

“…For example, the dlPFC region showing greatest efficacy in MDD has been reported to be a region anticorrelated to the sgCC, which also corresponds well to the SN’s dlPFC node (Fox et al, 2012). Stimulation of the dACC and adjacent dmPFC has also been employed in MDD (Bakker et al, 2015; Kreuzer et al, 2015), and stimulation of medial SN nodes in the dACC/dmPFC and adjacent pre-supplementary motor area have also shown promising effects in OCD (Mantovani et al, 2010; Dunlop et al, 2015a) and PTSD (Isserles et al, 2013). In healthy controls, there is evidence that rTMS of SN nodes such as the dlPFC or dmPFC/dACC can enhance or inhibit impulse control as measured on a delay-discounting task (Cho et al, 2010, 2015; Figner et al, 2010), and improve cognitive processing on executive functioning tasks (Esslinger et al, 2014), suggesting a generalized effect on cognitive control.…”

Section: Targeting the Sn-cstc With Therapeutic Brain Stimulationmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Peters

Dunlop

Downar³

2016

Front. Syst. Neurosci.

462

298

View full text Add to dashboard Cite

The salience network (SN) plays a central role in cognitive control by integrating sensory input to guide attention, attend to motivationally salient stimuli and recruit appropriate functional brain-behavior networks to modulate behavior. Mounting evidence suggests that disturbances in SN function underlie abnormalities in cognitive control and may be a common etiology underlying many psychiatric disorders. Such functional and anatomical abnormalities have been recently apparent in studies and meta-analyses of psychiatric illness using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). Of particular importance, abnormal structure and function in major cortical nodes of the SN, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been observed as a common neurobiological substrate across a broad spectrum of psychiatric disorders. In addition to cortical nodes of the SN, the network’s associated subcortical structures, including the dorsal striatum, mediodorsal thalamus and dopaminergic brainstem nuclei, comprise a discrete regulatory loop circuit. The SN’s cortico-striato-thalamo-cortical loop increasingly appears to be central to mechanisms of cognitive control, as well as to a broad spectrum of psychiatric illnesses and their available treatments. Functional imbalances within the SN loop appear to impair cognitive control, and specifically may impair self-regulation of cognition, behavior and emotion, thereby leading to symptoms of psychiatric illness. Furthermore, treating such psychiatric illnesses using invasive or non-invasive brain stimulation techniques appears to modulate SN cortical-subcortical loop integrity, and these effects may be central to the therapeutic mechanisms of brain stimulation treatments in many psychiatric illnesses. Here, we review clinical and experimental evidence for abnormalities in SN cortico-striatal-thalamic loop circuits in major depression, substance use disorders (SUD), anxiety disorders, schizophrenia and eating disorders (ED). We also review emergent therapeutic evidence that novel invasive and non-invasive brain stimulation treatments may exert therapeutic effects by normalizing abnormalities in the SN loop, thereby restoring the capacity for cognitive control. Finally, we consider a series of promising directions for future investigations on the role of SN cortico-striatal-thalamic loop circuits in the pathophysiology and treatment of psychiatric disorders.

show abstract

“…Stimulation of regions at depth of 3–4 cm, such as the leg motor area, can be achieved using the double cone coil [19]. It has also been used for direct activation of the pelvic floor and lower limb motor representation at the interhemispheric fissure, as well as for transsynaptic activation of the anterior cingulate cortex via stimulation of the medial frontal cortex [20]. …”

Section: Introductionmentioning

confidence: 99%

Comparison of the induced fields using different coil configurations during deep transcranial magnetic stimulation

Ueno

2017

PLoS ONE

113

View full text Add to dashboard Cite

Stimulation of deeper brain structures by transcranial magnetic stimulation (TMS) plays a role in the study of reward and motivation mechanisms, which may be beneficial in the treatment of several neurological and psychiatric disorders. However, electric field distributions induced in the brain by deep transcranial magnetic stimulation (dTMS) are still unknown. In this paper, the double cone coil, H-coil and Halo-circular assembly (HCA) coil which have been proposed for dTMS have been numerically designed. The distributions of magnetic flux density, induced electric field in an anatomically based realistic head model by applying the dTMS coils were numerically calculated by the impedance method. Results were compared with that of standard figure-of-eight (Fo8) coil. Simulation results show that double cone, H- and HCA coils have significantly deep field penetration compared to the conventional Fo8 coil, at the expense of induced higher and wider spread electrical fields in superficial cortical regions. Double cone and HCA coils have better ability to stimulate deep brain subregions compared to that of the H-coil. In the mean time, both double cone and HCA coils increase risk for optical nerve excitation. Our results suggest although the dTMS coils offer new tool with potential for both research and clinical applications for psychiatric and neurological disorders associated with dysfunctions of deep brain regions, the selection of the most suitable coil settings for a specific clinical application should be based on a balanced evaluation between stimulation depth and focality.

show abstract

The ACDC Pilot Trial: Targeting the Anterior Cingulate by Double Cone Coil rTMS for the Treatment of Depression

Cited by 59 publications

References 45 publications

Use of a Double-Cone Coil in Transcranial Magnetic Stimulation for Depression Treatment

Use of a Double-Cone Coil in Transcranial Magnetic Stimulation for Depression Treatment

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Comparison of the induced fields using different coil configurations during deep transcranial magnetic stimulation

Contact Info

Product

Resources

About