The acetic acid test in evaluation of subclinical genital papillomavirus infection: a comparative study on penoscopy, histopathology, virology and scanning electron microscopy findings.

Wikström, Arne; Hedblad, Mari‐Anne; Johansson, Bo; Kalantari, Mina; Syrjänen, Stina; Lindberg, Matthew R.; Krogh, Geo von

doi:10.1136/sti.68.2.90

Cited by 36 publications

(44 citation statements)

References 44 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study ® ndings provide further con® rmation that HPV plays a major aetiological role in acetowhite lesions of the penile mucosa which show histological evidence of koilocytosis which has also been shown in other studies 16,17 . Our results also con® rm the relative speci® city of histological koilocytosis in conjunction with clinical acetowhitening as an indicator of HPV infection.…”

Section: Discussionsupporting

confidence: 85%

Demonstration of Epstein-Barr virus DNA and human papillomavirus DNA in acetowhite lesions of the penile skin and the oral mucosa

Voog¹,

Ricksten²,

Olofsson³

et al. 1997

Int J STD AIDS

View full text Add to dashboard Cite

Oral hairy leukoplakia (OHL), thought to be caused by Epstein-Barr virus (EBV), shows similar histological and clinical features to human papillomavirus (HPV)-related acetowhite lesions of the vulva. We thus aimed to investigate the role of both HPV and EBV in men with acetowhite lesions of the penis. HPV but not EBV was significantly associated with penile acetowhite lesions showing koilocytosis compared with normal penile skin (12/20 versus 5/20, P < 0.02). HPV (5/20) and EBV (6/20) was detected in oral mucosa of some of these individuals. These results confirm an aetiological association between HPV and acetowhite penile lesions showing koilocytosis. HPV and EBV carriage in the oral mucosa is relatively common in young sexually active men.

show abstract

Section: Discussionsupporting

confidence: 85%

Demonstration of Epstein-Barr virus DNA and human papillomavirus DNA in acetowhite lesions of the penile skin and the oral mucosa

Voog¹,

Ricksten²,

Olofsson³

et al. 1997

Int J STD AIDS

View full text Add to dashboard Cite

show abstract

“…CA was confirmed by the acetic acid white assay (15). The patients were made aware of the advantages of liquid nitrogen cryotherapy combined with PC treatment, and strongly requested to use it following the consideration of abortion, long-term fertility problems, and other relevant risks.…”

Section: Introductionmentioning

confidence: 99%

Treatment of condyloma acuminata in pregnant women with cryotherapy combined with proanthocyanidins: Outcome and safety

Yang

Zhu

Dang

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract.Patients with condyloma acuminata (CA) during pregnancy represent a special risk group. The outcomes of many treatment methods for such cases are not satisfactory. The purpose of the present study was to evaluate the treatment outcome and safety of cryotherapy combined with proanthocyanidins (PCs) for CA in pregnant women. In this study, 46 pregnant women with CA were treated with cryotherapy combined with PCs. The lesions were sprayed with liquid nitrogen until the color of the wart changed from flesh colored to purple. A PC-containing formulation was then sprayed onto a non-woven fabric or single-layer gauze and applied to the affected area. The PC treatment was applied for 20 min, 2 or 3 times per day. All patients were followed up at 1 and 3 months. No visible warts remained after the cryotherapy and PC treatment. At the 1-month follow-up, only 1 case of recurrence was identified. At 3 months, 5 cases of recurrence were identified, and the recurrence rate was 10.9%. The satisfaction rate of the patients was 94% at 1 month and 87% at 3 months after treatment. All pregnancies resulted in healthy live births without delivery complications. Cryotherapy combined with PCs is indicated to be a safe and effective procedure and may serve as a treatment option for pregnant women with CA. IntroductionCondyloma acuminata (CA) are symptomatic genital lesions caused by human papilloma virus (HPV). Patients who have CA during pregnancy are a particular risk group. During pregnancy, vaginal secretions contacting the skin and mucous membranes are more abundant (1), meaning that the vulva will remain in a moist and immersed state, which would be problematic for CA patients. Several factors associated with pregnancy can promote the growth of HPV-induced lesions, for example, pregnancy hormones and reduced immunoresponsiveness. Cases of CA in pregnancy are normally characterized by fast-growing warts, and a reduced tolerance and poor compliance to treatment (2).Only a small number of treatments have been tested and recommended in pregnancy; at present, bi-and tri-chloroacetic acid (BCA/TCA), cryotherapy, electrocautery and surgical excision, including laser treatment, are the only recommended treatments. In addition to high recurrence rates, significant side effects have been observed for these methods, including local ulceration and scar formation, which may reduce a patient's compliance with treatment requirements (3). Moreover, medicine could potentially cause fetal malformation and laser treatment and surgical excision may cause uterine contraction, or even abortion (1,4).Cryotherapy is widely used for the treatment of CA. During the cryotherapy procedure, liquid nitrogen freezes the tissue and thereby causes necrosis; the treatment also stimulates specific immune responses, such as an immunomodulatory action of T lymphocytes against the remaining viable wart tissue (5,6). The advantages of cryotherapy are that it is simple, inexpensive, rarely causes scarring or depigmentation, and is safe for use in pregnancy.Pro...

show abstract

“…In the past few years, molecular biological techniques for the identification of HPV DNA or RNA have developed quickly [7,14,15]. These molecular tools [HC, polymerase chain reaction (PCR), in situ hybridization] permit the confirmation and direct classification of the virus, are equally applicable in [17], HPV infection is more frequent in male patients with recurrent balanoposthitis [10] and HPV is common among the male partners of HPV-positive women (even if the man is circumcised) [18]. The frequency of PCR-confirmed HPV infections among males attending STD clinics varies from 28% to 29.1% [11], whereas among volunteer soldiers undergoing military service in Finland, evidence for HPV DNA was obtained in 16.5% of cases [8].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of genital human papillomavirus infections established using different diagnostic techniques among males attending a urological clinic

Carvalho¹,

Syrjänen

Jacobino³

et al. 2006

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

These data suggest that both histology and peniscopy have low specificity in detecting male genital HPV. Accurate diagnosis of HPV infection can be confirmed by molecular detection methods only. Histology, however, plays an important role in the differential diagnosis. An appropriate diagnostic protocol for male genital HPV infections in a urological clinic should include peniscopy, histology and molecular diagnostic tools (HC or polymerase chain reaction).

show abstract

The acetic acid test in evaluation of subclinical genital papillomavirus infection: a comparative study on penoscopy, histopathology, virology and scanning electron microscopy findings.

Cited by 36 publications

References 44 publications

Demonstration of Epstein-Barr virus DNA and human papillomavirus DNA in acetowhite lesions of the penile skin and the oral mucosa

Demonstration of Epstein-Barr virus DNA and human papillomavirus DNA in acetowhite lesions of the penile skin and the oral mucosa

Treatment of condyloma acuminata in pregnant women with cryotherapy combined with proanthocyanidins: Outcome and safety

Prevalence of genital human papillomavirus infections established using different diagnostic techniques among males attending a urological clinic

Contact Info

Product

Resources

About