The Adipose-derived Stem Cell: Looking Back and Looking Ahead

Zuk, Patricia A.

doi:10.1091/mbc.e09-07-0589

Cited by 325 publications

(228 citation statements)

References 66 publications

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“…Subcutaneous adipose tissue is more abundant and often waste product in liposuction cosmetic and therapeutic type. 97,98 The ability of adult stem cells to secrete different types of molecules with anti-apoptotic, immunomodulatory, angiogenic, chemoattractant, and anti-scarring properties provides the basis for their use in regenerative medicine. 99 Investigative therapies have been used in clinical trials with some designed to treat autoimmune diseases, including multiple sclerosis, lupus erythematosus, and Crohn's disease, as well as diabetes mellitus, myocardial infarction, different types of cancer, neurological disorders, and ocular surface diseases.…”

Section: Potential Of Using Adult Stem Cells In the Regeneration Of Cmentioning

confidence: 99%

Corneal endothelium: developmental strategies for regeneration

Zavala

Jaime

Barrientos

et al. 2013

Eye

114

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The main treatment available for restoration of the corneal endothelium is keratoplasty. This procedure is faced with several difficulties, including the shortage of donor tissue, postsurgical complications associated with the use of drugs to prevent immune rejection, and a significant increase in the occurrence of glaucoma. Recently, surgical procedures such as Descemet's stripping endothelial keratoplasty have focused on the transplant of corneal endothelium, yielding better visual results but still facing the need for donor tissue. The emergent strategies in the field of cell biology and tissue cultivation of corneal endothelial cells aim at the production of transplantable endothelial cell sheets. Cell therapy focuses on the culture of corneal endothelial cells retrieved from the donor, in the donor's cornea, followed by transplantation into the recipient. Recently, research has focused on overcoming the challenge of harvesting human corneal endothelial cells and the generation of new biomembranes to be used as cell scaffolds in surgical procedures. The use of corneal endothelial precursors from the peripheral cornea has also demonstrated to be effective and represents a valuable tool for reducing the risk of rejection in allogeneic transplants. Several animal model reports also support the use of adult stem cells as therapy for corneal diseases. Current results represent important progresses in the development of new strategies based on alternative sources of tissue for the treatment of corneal endotheliopathies. Different databases were used to search literature: PubMed, Google Books, MD Consult, Google Scholar, Gene Cards, and NCBI Books. The main search terms used were: 'cornea AND embryology AND transcription factors', 'human endothelial keratoplasty AND risk factors', '(cornea OR corneal) AND (endothelium OR endothelial) AND cell culture', 'mesenchymal stem cells AND cell therapy', 'mesenchymal stem cells AND cornea', and 'stem cells AND (cornea OR corneal) AND (endothelial OR endothelium)'.

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Section: Potential Of Using Adult Stem Cells In the Regeneration Of Cmentioning

confidence: 99%

Corneal endothelium: developmental strategies for regeneration

Zavala

Jaime

Barrientos

et al. 2013

Eye

114

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“…Furthermore, it was recorded that the proliferation rate of AD-MSCs seems to be greater than that of bone marrow-derived MSCs (BM-MSCs) as much as 40-fold [20] . Indeed, AD-MSCs are like stem cells isolated from bone marrow in morphology, the ability to undergo multilineage differentiation and cell surface phenotype both in vitro and in vivo [47] .…”

Section: Introductionmentioning

confidence: 99%

Transplanted Adipose Derived Mesenchymal Stem Cells Attenuate The Acute Renal Injury Induced by Cisplatin in Rats

Sakr

Elhai

Zeid

et al. 2017

Egyptian Journal of Histology

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Background: Traditional therapeutic strategies used for the treatment of acute kidney injury (AKI) proved to be less effective in reducing the morbidity and mortality rate. Recently, stem cell therapy showed a promise for treatment of this complex disorder. Aim: To investigate the therapeutic role of adipose-derived mesenchymal stem cells (AD-MSCs) in treatment of cisplatininduced nephrotoxicity as a model of AKI. Material and Methods: Twenty adult female Wister rats were divided equally into four groups. Group I was the control, the other three groups received a single intraperitoneal injection of cisplatin (5 mg /kg), where group II were sacrificed after one day from cisplatin injection, group III were sacrificed after seven days from cisplatin injection and group IV received adult male rat AD-MSCs (2x106 cells/rat) in tail vein one day after cisplatin injection and were sacrificed seven days after cisplatin injection. Results: The histopathological changes in the renal cortex were more obviously detected in group III than in group II. These changes include congested and shrunken glomeruli, dilated Bowman's space and loss of proximal convoluted tubules brush borders. Moreover, distal tubular cells showed cytoplasmic vacuolization, with pyknotic nuclei and presence of intraluminal hyaline casts. Interstitial collagen deposition was also noticed. In group IV, AD-MSCs administration almost restores the renal histological architecture. Increased tubular cell proliferation with marked reduction of the interstitial inflammation and fibrosis were also detected. However, some renal glomeruli and tubules showed degenerative changes. Male rat derived-stem cells were detected in the female kidney tissue by Y chromosome PCR technique. Conclusion: Administration of AD-MSCs had a potential regenerative effect for the management of AKI.

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“…The developed strategies include the transplantation of stem cells, the manipulation of the patient's own cells, and the use of scaffold materials that trigger biological signals in order to accelerate the regenerative processes. The successful application of innovative therapies has been confirmed in clinical trials and experiments assessing the healing of broken bones, severe burns, blindness, deafness, and heart, blood vessel, nerve and muscle damage, and in the treatment of many other diseases [1]. However, the availability of stem cells remains a challenge for scientists and clinicians.…”

Section: Introductionmentioning

confidence: 99%

Stem cells from adipose tissue

Witkowska-Zimny

Walenko

2011

Cellular and Molecular Biology Letters

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This is a review of the growing scientific interest in the developmental plasticity and therapeutic potential of stromal cells isolated from adipose tissue. Adipose-derived stem/stromal cells (ASCs) are multipotent somatic stem cells that are abundant in fat tissue. It has been shown that ASCs can differentiate into several lineages, including adipose cells, chondrocytes, osteoblasts, neuronal cells, endothelial cells, and cardiomyocytes. At the same time, adipose tissue can be harvested by a minimally invasive procedure, which makes it a promising source of adult stem cells. Therefore, it is believed that ASCs may become an alternative to the currently available adult stem cells (e.g. bone marrow stromal cells) for potential use in regenerative medicine. In this review, we present the basic information about the field of adipose-derived stem cells and their potential use in various applications.

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The Adipose-derived Stem Cell: Looking Back and Looking Ahead

Cited by 325 publications

References 66 publications

Corneal endothelium: developmental strategies for regeneration

Corneal endothelium: developmental strategies for regeneration

Transplanted Adipose Derived Mesenchymal Stem Cells Attenuate The Acute Renal Injury Induced by Cisplatin in Rats

Stem cells from adipose tissue

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