The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma

You, Huihui; Chen, Shaohui; Mao, Lin; Li, Bing; Yuan, Ye; Li, Rui; Yang, Xu

doi:10.1016/j.fct.2014.06.012

Cited by 57 publications

(28 citation statements)

References 70 publications

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“…Depletion of GSH, or production of ROS inhibited the production of the Th1 cytokine and influenced the balance between Th1 and Th2 cells [26]. In this study we show that the intracellular oxidation state was initially induced by FITC sensitization, followed by a disruption of the Th1/Th2 balance, indicated by the production of inflammatory factors IL-4 (typical Th2 cytokine) and IFN-γ (Th1 cytokine).…”

Section: Discussionmentioning

confidence: 57%

Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB

et al. 2016

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Several epidemiological studies have suggested a possible link between exposure to Diisononyl phthalate (DINP) and the development of allergies. These findings remain controversial since there is insufficient scientific evidence to assess the ability of DINP to influence allergic immune responses. In addition, the mechanisms behind DINP-caused allergic diseases have not been fully elucidated. In this study, Balb/c mice were orally exposed to DINP for 3 weeks and were then sensitized with fluorescein isothiocyanate (FITC). We showed that oral exposure to DINP could aggravate allergic-dermatitis-like lesions, indicated by an increase in the number of mast cells, and in increased skin edema in FITC-induced contact hypersensitivity. This deterioration was concomitant with increased total serum immunoglobulin-E and Th2 cytokines. We determined the oxidative damage and the activation of nuclear factor-kb (NF-kB). The data demonstrated that DINP could promote oxidative damage and the activation of NF-kB in the skin. The expression of thymic stromal lymphopoietin and the activation of signal transducer and activator of transcriptions 3, 5 and 6 were enhanced concomitant with exacerbated allergic dermatitis effects and the activation of NF-kB induced by DINP. These effects were alleviated by pyrollidine dithiocarbamate, an inhibitor of NF-kB. The results suggest that oral exposure to DINP aggravated allergic contact dermatitis, which was positively regulated via NF-kB.

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Section: Discussionmentioning

confidence: 57%

Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB

et al. 2016

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“… 2014 ; You et al. 2014 ). The presence of MDA in lung tissue may increase the chemotaxis of leucocytes.…”

Section: Resultsmentioning

confidence: 99%

Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model

Zemmouri

Sekiou

Ammar

et al. 2017

Pharmaceutical Biology

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Context: To find bioactive medicinal herbs exerting anti-asthmatic activity, we investigated the effect of an aqueous extract of Urtica dioica L. (Urticaceae) leaves (UD), the closest extract to the Algerian traditional use.Objective: In this study, we investigated the in vivo anti-asthmatic and antioxidant activities of nettle extract.Materials and methods: Adult male Wistar rats were divided into four groups: Group I: negative control; group II: Ovalbumin sensitized/challenged rats (positive control); group III: received UD extract (1.5 g/kg/day) orally along the experimental protocol; group IV: received UD extract (1.5 g/kg/day) orally along the experimental protocol and sensitized/challenged with ovalbumin. After 25 days, blood and tissue samples were collected for haematological and histopathological analysis, respectively. The oxidative stress parameters were evaluated in the lungs, liver and erythrocytes. Then, correlations between markers of airway inflammation and markers of oxidative stress were explored.Results: UD extract significantly (p < 0.01) inhibited eosinophilia increases in BALF (−60%) and the levels of leucocytes (−32.75%) and lymphocytes (−29.22%) in serum, and effectively suppressed inflammatory cells recruitment in the asthmatic rat model. Besides, the lipid peroxidation generated by allergen administration was significantly (p < 0.05) diminished by UD treatment in lung tissue (−48.58%). The nettle extract was also investigated for the total phenolic content (30.79 ± 0.96 mg gallic acid/g dry extract) and shows DPPH radical scavenging activity with 152.34 ± 0.37 μg/mL IC50 value.Conclusions: The results confirmed that UD administration might be responsible for the protective effects of this extract against airway inflammation.

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“…Those treated with vitamin E in addition to DEHP and OVA developed attenuated oxidative stress responses. [52]…”

Section: Animal Modelsmentioning

confidence: 99%

The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings

Robinson

Miller

2015

Curr Envir Health Rpt

150

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In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. Epidemiologic studies indicate that exposure to endocrine disrupting chemicals produced in high volumes, including bisphenol A (BPA) and phthalates, are ubiquitous. The links between their exposure and the development of allergy, asthma and immune dysfunction have been studied in vitro, in vivo and through human cohort studies. The purpose of this review is to examine the current body of research and to highlight deficits and strengths of current findings. Emerging science indicates that deleterious immunologic changes, including increased propensity to develop wheeze, allergy and asthma after dietary and inhalation exposure to these chemicals, may be occurring.

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The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma

Cited by 57 publications

References 70 publications

Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB

Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB

Urtica dioica attenuates ovalbumin-induced inflammation and lipid peroxidation of lung tissues in rat asthma model

The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings

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