The African Descent and Glaucoma Evaluation Study (ADAGES)

Sample, Pamela A.; Girkin, Christopher A.; Zangwill, Linda M.; Jain, Sonia; Racette, Lyne; Becerra, Lida M.; Weinreb, Robert N.; Medeiros, Felipe A.; Wilson, M. Roy; León-Ortega, Julio De; Tello, Celso; Bowd, Christopher; Liebmann, Jeffrey M.

doi:10.1001/archophthalmol.2009.187

Cited by 293 publications

(314 citation statements)

References 49 publications

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“…However, central corneal thickness measurement is important because corneal thickness may mask the accurate measurement of IOP, which may be underestimated in persons with thinner central corneal thicknesses as documented in an African-derived population. 54 The use of monocular disc photographs with a mid-point disc-macular field image is a limitation. As the images were not centered on the disc, this may have impacted on disc markings and the results may not be directly comparable to those in other studies that used a different focus point.…”

Section: Discussionmentioning

confidence: 99%

Nigeria Normative Data for Defining Glaucoma in Prevalence Surveys

Kyari

Abdull

Sallo

et al. 2015

Ophthalmic Epidemiology

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Section: Discussionmentioning

confidence: 99%

Nigeria Normative Data for Defining Glaucoma in Prevalence Surveys

Kyari

Abdull

Sallo

et al. 2015

Ophthalmic Epidemiology

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“…Methodologic details have been described previously. 25 Informed consent was obtained from all the participants, and the institutional review boards and human subjects committees of all three sites approved all the methods. All methods adhered to the tenets of the Declaration of Helsinki for research involving human subjects.…”

Section: Methodsmentioning

confidence: 99%

“…Details of the methodology used to grade optic disc photographs at the UCSD Optic Disc Reading Center have been provided elsewhere. 25,30,31 …”

Section: Stereophotograph Gradingmentioning

confidence: 99%

The Relationship Between Cup-to-Disc Ratio and Estimated Number of Retinal Ganglion Cells

Tatham

Weinreb

Zangwill

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the relationship between cup-to-disc ratio (CDR) and estimates of retinal ganglion cell (RGC) number.METHODS. This cross-sectional study included 156 healthy eyes, 53 glaucoma suspects, and 127 eyes with glaucoma. All eyes had standard automated perimetry (SAP), Cirrus SD-OCT, and stereoscopic optic disc photography within 6 months. CDR was determined from stereoscopic photographs by two or more masked graders. The number of RGCs in each eye was estimated using a published model that combines estimates of RGC number from SAP sensitivity thresholds and SD-OCT retinal nerve fiber layer measurements.RESULTS. The mean estimated RGC count was 1,063,809 in healthy eyes; 828,522 in eyes with suspected glaucoma; and 774,200 in early, 468,568 in moderate, and 218,471 in advanced glaucoma. Healthy eyes had a mean vertical CDR of 0.45 6 0.15 vs. 0.80 6 0.16 in glaucomatous eyes. There was good correlation between stereophotographic vertical CDR and SD-OCT vertical CDR (R 2 ¼ 0.825; P < 0.001). The relationship between estimated RGCs and vertical CDR was best represented using a third degree polynomial regression model, including age and optic disc area, which accounted for 83.3% of the variation in estimated RGC counts. The nonlinear relationship between RGC estimates and CDRs indicated that eyes with a large CDR would require loss of large RGC numbers for a small increase in CDR. CONCLUSIONS.The relationship between estimated RGC counts and CDR suggests that assessment of change in CDR is an insensitive method for evaluation of progressive neural losses in glaucoma. Even relatively small changes in CDR may be associated with large losses of RGCs, especially in eyes with large CDRs. (ClinicalTrials.gov numbers, NCT00221923, NCT00221897.)

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“…Both centers are responsible for certifying visual field and imaging technicians and photograph graders, processing any data-related queries to the DIGS study coordinator, and requesting that tests be repeated when needed. 24 All patients from both studies who met the inclusion criteria were enrolled. Informed consent was obtained from all participants, the Human Subjects Committees approved all protocols, and the methods described adhered to the tenets of the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

A Comparison of Rates of Change in Neuroretinal Rim Area and Retinal Nerve Fiber Layer Thickness in Progressive Glaucoma

Alencar

Zangwill

Weinreb

et al. 2010

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To evaluate and compare rates of change in neuroretinal rim area (RA) and retinal nerve fiber layer thickness (RNFLT) measurements in glaucoma patients, those with suspected glaucoma, and normal subjects observed over time. METHODS. In this observational cohort study, patients recruited from two longitudinal studies (Diagnostic Innovations in Glaucoma Study-DIGS and African Descent and Evaluation Study-ADAGES) were observed with standard achromatic perimetry (SAP), optic disc stereophotographs, confocal scanning laser ophthalmoscopy (HRT-3; Heidelberg Engineering, Heidelberg, Germany), and scanning laser polarimetry (GDx-VCC; Carl Zeiss Meditec, Inc., Dublin, CA). Glaucoma progression was determined by the Guided Progression Analysis software for standard automated perimetry [SAP] and by masked assessment of serial optic disc stereophotographs by expert graders. Random-coefficients models were used to evaluate rates of change in average RNFLT and global RA measurements and their relationship with glaucoma progression. RESULTS. At baseline, 194 (31%) eyes were glaucomatous, 347 (55%) had suspected glaucoma, and 88 (14%) were normal. Forty-six (9%) eyes showed progression by SAP and/or stereophotographs, during an average follow-up of 3.3 (+/-0.7) years. The average rate of decline for RNFLT measurements was significantly higher in the progressing group than in the nonprogressing group (-0.65 vs. -0.11 microm/y, respectively; P < 0.001), whereas RA decline was not significantly different between these groups (-0.0058 vs. -0.0073 mm(2)/y, respectively; P = 0.727). The areas under the receiver operating characteristic (ROC) curves used to discriminate progressing versus nonprogressing eyes were 0.811 and 0.507 for the rates of change in the RNFLT and RA, respectively (P < 0.001). CONCLUSIONS. The ability to discriminate eyes with progressing glaucoma by SAP and/or stereophotographs from stable eyes was significantly greater for RNFLT than for RA measurements.

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The African Descent and Glaucoma Evaluation Study (ADAGES)

Cited by 293 publications

References 49 publications

Nigeria Normative Data for Defining Glaucoma in Prevalence Surveys

Nigeria Normative Data for Defining Glaucoma in Prevalence Surveys

The Relationship Between Cup-to-Disc Ratio and Estimated Number of Retinal Ganglion Cells

A Comparison of Rates of Change in Neuroretinal Rim Area and Retinal Nerve Fiber Layer Thickness in Progressive Glaucoma

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