The Age of Multistimuli-responsive Nanogels: The Finest Evolved Nano Delivery System in Biomedical Sciences

Prevent or Cure—The Unprecedented Need for Self‐Reporting Materials

“…Thus,t he changes in the fluorescence emission allow the in situ monitoring of microenvironmental pH values,w hich is especially useful in the field of biology and medicine for the precise development of nanomedicine,f or example,f or the treatment of (benign/malignant) cancer diseases.B yl oading pharmaceutical active molecules into pH-responsive nanoparticles,t hese entities are exclusively released upon uptake of diseased cells within the range of suitable pH values.T hus,i nc ontrast to conventional nanomedicines without pH-responsive properties,t he selectivity, sensitivity,a nd efficiencyo ft he active compounds were improved, while simultaneously unwanted cellular cytoxicity and side effects may be reduced. [98][99][100][101][102] Similarly,aminobromomaleimide (ABM) has been incorporated into particle cores as fluorophore to probe the core hydrophobicity. [103] Thep articles were synthesized via emulsion copolymerization of ah ydrophilic shell-forming monomer (oligoethylene glycol methacrylate,O EGMA), ah ydrophobic core-forming segment (N,N-diethylaminoethyl methacrylate,D EAEMA), and the respective fluorescent ABM monomer,represented in Figure 10 A.…”

“…By loading pharmaceutical active molecules into pH‐responsive nanoparticles, these entities are exclusively released upon uptake of diseased cells within the range of suitable pH values. Thus, in contrast to conventional nanomedicines without pH‐responsive properties, the selectivity, sensitivity, and efficiency of the active compounds were improved, while simultaneously unwanted cellular cytoxicity and side effects may be reduced [98–102] …”

“…Thus, in contrast to conventional nanomedicines without pH‐responsive properties, the selectivity, sensitivity, and efficiency of the active compounds were improved, while simultaneously unwanted cellular cytoxicity and side effects may be reduced. [ 98 , 99 , 100 , 101 , 102 ]…”

Vorbeugen oder Heilen – die beispiellose Notwendigkeit von selbstberichtenden Materialien

“…Im Gegensatz zu konventionellen Nanomedikamenten ohne pHresponsive Eigenschaften konnte so die Selektivität, Sensitivitätu nd Effizienz der Wirkstoffe verbessert werden, während gleichzeitig unerwünschte zelluläre Zytoxizitätu nd Nebenwirkungen reduziert werden konnten. [98][99][100][101][102] Auf ähnliche Weise wurde Aminobrommaleimid (ABM) als Fluorophor in Partikelkerne eingearbeitet, um die Hydrophobie des Kerns zu untersuchen. [103]…”

“…Durch die Beladung von pH‐responsiven Nanopartikeln mit pharmazeutisch aktiven Molekülen werden diese ausschließlich von kranken Zellen mit passendem pH‐Wert aufgenommen und freigesetzt. Im Gegensatz zu konventionellen Nanomedikamenten ohne pH‐responsive Eigenschaften konnte so die Selektivität, Sensitivität und Effizienz der Wirkstoffe verbessert werden, während gleichzeitig unerwünschte zelluläre Zytoxizität und Nebenwirkungen reduziert werden konnten [98–102] …”