The Aging Process Alters IL-1β and CD63 Levels Differently in Extracellular Vesicles Obtained from the Plasma and Cerebrospinal Fluid

Andrade, Gisele Gomes de; Cechinel, Laura Reck; Bertoldi, Karine; Galvão, Fernando; Worm, Paulo Valdeci; Siqueira, Ionara Rodrigues

doi:10.1159/000488943

Cited by 25 publications

(22 citation statements)

References 22 publications

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“…Boilard et al (2010) suggested that MPs originating from platelet are able to promote inflammatory reactions and stimulate cytokine responses in synovial fibroblasts via interleukin-1 (IL-1) signaling. Gomes de Andrade et al (2018) revealed that aging could cause changes in the profiles of circulating exosomes. An age-related increase in CD63 levels was observed in exosomes from cerebrospinal fluid (CSF), and a significant decrease in IL-1β levels was observed in exosomes from the plasma of the older group of male Wistar rats (Gomes de Andrade et al, 2018).…”

Section: Inflammatory Cargosmentioning

confidence: 99%

“…Gomes de Andrade et al (2018) revealed that aging could cause changes in the profiles of circulating exosomes. An age-related increase in CD63 levels was observed in exosomes from cerebrospinal fluid (CSF), and a significant decrease in IL-1β levels was observed in exosomes from the plasma of the older group of male Wistar rats (Gomes de Andrade et al, 2018). These results suggest that changes in IL-1β levels of the exosomes are significantly correlated with age-related inflammatory responses.…”

Section: Inflammatory Cargosmentioning

confidence: 99%

“…Alleviation diseases development. Mesri and Altieri, 1998;Boilard et al, 2010;Harp et al, 2016;Munros et al, 2017;Gomes de Andrade et al, 2018;Khalaj et al, 2019;Qiu et al, 2019;Sun et al, 2019 Mechanism: the NF-κB signaling pathway Zhang et al, 2019Wu et al, 2018Liu et al, 2019;Mobarak et al, 2019;Yoshida et al, 2019;Zhao et al, 2019 EVs: Extracellular vesicles. NF-κB: nuclear factor kappa B.…”

Section: Clinicalmentioning

confidence: 99%

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Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases

Liu

Shen

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Extracellular vesicles (EVs), present in cell culture media and several body fluids, play a prominent role in intercellular communication under physiological and pathological conditions. We performed a systematic literature search to review evidence regarding the existence, composition, and release of different EVs, as well as the biomarkers, cargos, and separation methods. We also reviewed the potential of EVs to transport cargos and alter the function and phenotype of recipient cells associated with aging and reproductive diseases, including polycystic ovary syndrome and endometriosis. In aging, EVs promote inflammatory reactions and offsetting the occurrence of aging. In the polycystic ovary syndrome and endometriosis, EVs and their cargos are involved in the occurrence of diseases, therapeutic strategies, and perform as non-invasive biomarkers. As the study of EVs is still in the early stages, it is not surprising that most of the current literature only describes their possible roles.

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Section: Inflammatory Cargosmentioning

confidence: 99%

Section: Inflammatory Cargosmentioning

confidence: 99%

Section: Clinicalmentioning

confidence: 99%

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Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases

Liu

Shen

Zhang

et al. 2020

Front. Cell Dev. Biol.

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“…Evidence has been mounting suggesting that exosomes, isolated from either blood (Gauthier et al, 2017;Hamlett, Goetzl, et al, 2016) or CSF (Gomes de Andrade et al, 2018;Otake et al, 2019), might be useful in capturing relevant neuropathological processes within CNS neurons. Although only one manuscript could be found where investigators compared cargo of exosomes derived from blood versus CSF (Chen et al, 2019), this is indeed a promising new direction.…”

Section: Exosome Cargo In Ad and Ds-admentioning

confidence: 99%

Exosome release and cargo in Down syndrome

Hamlett

LaRosa

Mufson

et al. 2019

Developmental Neurobiology

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Down syndrome (DS) is a multisystem disorder affecting 1 in 800 births worldwide. Advancing technology, medical treatment, and social intervention have dramatically increased life expectancy, yet there are many etiologies of this disorder that are in need of further research. The advent of the ability to capture extracellular vesicles (EVs) in blood from specific cell types allows for the investigation of novel intracellular processes. Exosomes are one type of EVs that have demonstrated great potential in uncovering new biomarkers of neurodegeneration and disease, and also that appear to be intricately involved in the transsynaptic spread of pathogenic factors underlying Alzheimer's disease and other neurological diseases. Exosomes are nanosized vesicles, generated in endosomal multivesicular bodies (MVBs) and secreted by most cells in the body. Since exosomes are important mediators of intercellular communication and genetic exchange, they have emerged as a major research focus and have revealed novel biological sequelae involved in conditions afflicting the DS population. This review summarizes current knowledge on exosome biology in individuals with DS, both early in life and in aging individuals. Collectively these studies have demonstrated that complex multicellular processes underlying DS etiologies may include abnormal formation and secretion of extracellular vesicles such as exosomes.

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“…The levels of acetylcholine, noradrenaline, dopamine, serotonin, gamma-aminobutyric acid, homovanilinic acid and other neurotransmitters (Straathof et al, 2018;Jacob et al, 2018) decrease in different brain parts. This is due to the fact that with age, the activity of certain enzymes involved in the synthesis of neurotransmitters decreases (Vrankoviс, 2016;Gomes de Andrade et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Age-related characteristics of spectral bioelectric activity of the trophotropic zone of the hypothalamus in female rats

Mukvych¹,

Lyashenko²,

Lukashov³

2018

Regul. Mech. Biosyst.

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The purpose of the study was to determine the functional state of the trophotropic zone of the hypothalamus in female rats of different age groups according to bioelectric activity indices. Experiments were carried out on non-linear white outbred female rats. Animals were divided into IV groups: I group (2.5 months) the juvenile puberty period, II group (eight months) the young age of the reproductive period, III group (fourteen months) the mature age of the reproductive period, IV group (21 months) rats of presenile age of the pronounced senile changes period. Rats of the studied groups underwent Electric Hypothalamus Test (EGtG) of the trophotropic zone. The prevalence of low-frequency components of EGtG in female rats of the juvenile age and the domination of bioelectric activity in the delta range of the investigated hypothalamic region is determined. The young age in females was marked by an increase in all values of normalized spectral power, except the theta-like activity, which in turn was characterized by a possible decrease in the indices. In female rats, from young to presenile age, a gradual increase in the share of absolute power of high-frequency components of EGtG was observed, which was manifested in the functional activation of desynchronizing effect on bioelectric activity of the investigated hypothalamic region. There was an increase in theta-like and beta-like activity while there was a reduction in the percentage of alpha and especially delta wave power. In the female rats of the presenile age, the delta-like activity indices slightly recovered and exceeded those of mature female rats, theta and alpha-like activities underwent a significant decline in values and were represented by the lowest values, while beta-like activity was observed at the highest rates. However, it was precisely the mature female rats that showed a significant predominance of beta-like activity, which is evidence of the powerful desynchronizing mechanisms functioning. Electrophysiological indices indicate synaptic plasticity growth deficiency in female rats of the youngest age and factors of its degradation in those of presenile age, respectively. The power and the desynchronization rhythms representation increase is characteristic of the most productive age period with the most developed neurosynapticplasticity inherent to it.

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The Aging Process Alters IL-1β and CD63 Levels Differently in Extracellular Vesicles Obtained from the Plasma and Cerebrospinal Fluid

Cited by 25 publications

References 22 publications

Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases

Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases

Exosome release and cargo in Down syndrome

Age-related characteristics of spectral bioelectric activity of the trophotropic zone of the hypothalamus in female rats

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