The AGT epistasis pattern proposed a novel role for ZBED9 in regulating blood pressure: Tehran Cardiometabolic genetic study (TCGS)

Akbarzadeh, Mahdi; Riahi, Parisa; Kolifarhood, Goodarz; Lanjanian, Hossein; Alipour, Nadia; Bonab, Leila Najd Hassan; Moghadas, Mohammad Reza; Sabour, Siamak; Azizi, Fereidoun; Daneshpour, Maryam Sadat

doi:10.1016/j.gene.2022.146560

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…The single-locus analysis identi ed two missense variants in ZBED9 (rs450630) and AGT (rs4762) associated with hypertension. The G allele of rs450630 showed an antagonistic effect on hypertension, but interestingly, IGENT analysis revealed signi cant epistasis effects for different combinations of ZBED9, AGT, and TNXB loci in the further analysis [14].…”

Section: Resultsmentioning

confidence: 88%

Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine

Daneshpour

Lanjanian

Sedaghati-Khayat

et al. 2022

Preprint

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The Tehran Cardiometabolic Genetic Study (TCGS) is a large population-based cohort study with periodic follow-ups, which created a comprehensive database of 20,367 participants born between 1911-2015 selected from 4 different longitudinal, ongoing, and family-based studies. The study aims to identify the potential targets for prevention and intervention for non-communicable diseases in mid-life and late life. The study focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the cohort expanded the information by coding all health-related complications (hospitalization outcomes and self-reports) based on ICD11 coding and confirming the consanguineous marriage with genetic markers. This article presents an update on the rationale and design of the study. We also present a summary of our findings and our goals toward precision medicine.

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Section: Resultsmentioning

confidence: 88%

Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine

Daneshpour

Lanjanian

Sedaghati-Khayat

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Several other traits previously reported to be related to birth order were also identified, including blood pressure 2 (cardiac autonomic responses (deceleration capacity), diastolic blood pressure, systolic blood pressure, atherosclerosis, preeclampsia, maternal hypertensive disorders in pregnancy), metabolism 4 (serum liver enzyme levels (alanine aminotransferase, ALT), serum liver enzyme levels (gamma-glutamyl transferase, GGT), metabolic trait, hepatic steatosis, hepatic fat), birth weight 52 and body mass index (BMI) 53 . The top association in our DMR analysis was ZBED9 , recently identified as a regulatory gene for blood pressure 54 .…”

Section: Discussionmentioning

confidence: 89%

A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Li,

Spitz,

Ghantous

et al. 2024

Commun Biol

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Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.

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“…Furthermore, single-locus analysis identified two missense variants in ZBED9 (rs450630) and AGT (rs4762) associated with hypertension. Interestingly, the G allele of rs450630 exhibited an antagonistic effect on hypertension, but IGENT analysis revealed significant epistasis effects for different combinations of ZBED9, AGT , and TNXB loci in the further analysis [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Cohort profile update: Tehran cardiometabolic genetic study

et al. 2023

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The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups. TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for prevention and intervention for non-communicable diseases that may develop in mid-life and late life. TCGS cohort focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the TCGS cohort has augmented by encoding all health-related complications, including hospitalization outcomes and self-reports according to ICD11 coding, and verifying consanguineous marriage using genetic markers. This research provides an update on the rationale and design of the study, summarizes its findings, and outlines the objectives for precision medicine. Supplementary Information The online version contains supplementary material available at 10.1007/s10654-023-01008-1.

show abstract

The AGT epistasis pattern proposed a novel role for ZBED9 in regulating blood pressure: Tehran Cardiometabolic genetic study (TCGS)

Cited by 6 publications

References 24 publications

Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine

Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine

A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Cohort profile update: Tehran cardiometabolic genetic study

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