2024
DOI: 10.1042/bst20241510
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The AICD interactome: implications in neurodevelopment and neurodegeneration

Laura Lok-Haang Ng,
Jessica Chow,
Kwok-Fai Lau

Abstract: The pathophysiological mechanism involving the proteolytic processing of amyloid precursor protein (APP) and the generation of amyloid plaques is of significant interest in research on Alzheimer's disease (AD). The increasing significance of the downstream AD-related pathophysiological mechanisms has sparked research interest in other products of the APP processing cascades, including the APP intracellular domain (AICD). The potential importance of AICD in various cellular processes in the central nervous syst… Show more

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