The Amazon Ocular Oncology Center: The first three years

Cohen, S D; Pretyman, Caroline S.; Santana, R. M.; Singh, Nakul; Morales, Melina Correia; Belfort, Rubens

doi:10.5935/0004-2749.20190024

Cited by 3 publications

(3 citation statements)

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“…An ophthalmological center in Northern Brazil published the epidemiology of their first 3-year experience and from 71 cases of eye cancer, with 8 reported cases of uveal melanoma [21]. Another Brazilian study reported 269 orbital tumors with 6.7% of malignant melanomas of the orbital cavity, although their focus was on management of these patients and those could be not considered uveal melanomas [22].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of uveal melanoma in Brazil

et al. 2020

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Purpose To report the prevalence of uveal melanoma in a Hospital database in Brazil over the period of 16 years (2000 to 2016). Design Descriptive epidemiological study evaluating the Brazilian Hospital Based Cancer Registries. Participants/methods Uveal melanomas were identified based on ICD-O-3 codes C69.3 [choroid], C69.4 [ciliary body and iris], and C69.2 [retina]) derived from the Integrator Registry database. Kolmogorov–Smirnov Test was used for evaluation of normality of data, t-test and Chi square were used for categorical and continuous variables respectively using SPSS Software. Main outcome measures Age, sex, education, regional distribution, clinical staging at the diagnosis, time from diagnosis to treatment (≤ 60 days versus > 60 days) and first-course therapy (surgery, chemotherapy, radiotherapy or a combination of such). Results There were 2166 cases of uveal melanoma representing 5.4% of all cases of melanoma. Histological confirmation of uveal melanoma was available in all cases. Higher prevalence of 1139 cases (52.6%) in women than 1027 cases (47.4%) in men was observed. Age distribution revealed 1411 cases (65.1%) in the group between 41 and 69 years old. A total of 429 (19.8%) patients were classified as initial disease and 334 (15.4%) as advanced (regional or distant metastases). Staging as initial disease was more frequent (113–24.8%) in patients with > 8 school years than in patients with < 8 school years (179–17.6%) reflecting disparities in healthcare access between those two populations. No difference was noticed in terms of diagnosis, staging and treatment after the Brazilian “60 days law” (Federal Law 12.732/12) came into effect in 2013 regulating the maximum period that a patient with cancer has to wait until start the treatment. Conclusion Epidemiological data is critical for planning early treatment strategies and allocating medical resources. This study intended to understand the characteristics of uveal melanoma in Brazil.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of uveal melanoma in Brazil

et al. 2020

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“…To better identify ocular surface and orbit masses, collection of cases, differentiation of pathological types and epidemiological changes are needed. Different regions, races, gender, age, and epidemiology can usually lead to the diverse occurrence and development progresses of ocular surface and orbit masses (12)(13)(14)(15)(16)(17). In our study, over 90% the tumors were benign, while malignant tumors accounted for 8.5%.…”

Section: Discussionmentioning

confidence: 48%

The clinicopathological analysis of ocular and orbit tumors in southeast of China

et al. 2023

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PurposeThe purpose of this study is to describe the clinicopathologic characteristics of ocular surface and orbit tumors in the Southeast of China and explore the method to differentiate the benign and malignant masses.Materials and methods3468 patients undergoing mass resection from January 2015 to December 2020 were selected as observation subjects and were classified into benign and malignant masses according to postoperative pathology. The clinicopathologic characteristics were collected, including gender, age, pathological tissue signs, and pathological signs. Multivariate Logistic regression analysis of independent risk factors of malignant mass was applied to establish a diagnostic model and the efficacy was evaluated by the subject working characteristics (ROC) curve.ResultsBenign tumors accounted for 91.5% of all cases, and malignant tumors accounted for 8.5%. The most common ocular benign tumors were nevi (24.2%), granuloma (17.1%), and cysts (16.4%). The most common ocular malignant tumors were malignant lymphoma (32.1%) and Basal cell carcinoma (20.2%). As for the histologic origin, melanocytic origin was on the list with 819 (23.6%), mesenchymal 661 (19.1%), epithelial 568 (16.3%), cystic 521 (15.0%), skin adnexal 110 (3.1%), lymphoid 94 (2.8%), and Neural 25(0.8%). Based on the gender, age, tumor location, and the pathological tissue image feature (including differentiation, structural atypia, covering epithelial, keratosis, nest structure/distribution, nuclear atypia, cytoplasmic change and nuclear division), the diagnostic model had predictive value to differentiate the benign and malignant masses.ConclusionMost ocular surface and orbit tumors are benign. Tumor diagnosis is relative to the patient’s age, gender, tumor location, and pathologic characteristics. We generated a satisfactory diagnostic model to differential diagnosis of benign and malignant masses.

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“…In this context, a study carried out in an ocular oncology center in Manaus showed that 221 patients sought care at the service for ocular neoplasm, in three years, of which 71 had malignant lesions. (2) Another study, carried out in an ophthalmology center in São Paulo, showed that of 3,446 surgical specimens with histopathological evaluation, 324 were malignant lesions of the eyelids, especially basal cell carcinoma. (3) Regarding uveal melanoma, from 2000 to 2016, there were 2,166 cases in Brazil, which represented 5.4% of all causes of melanoma in that period, according to data from the National Cancer Institute.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the mortality by eye cancer from 2010 to 2019 in Brazil

Barbosa¹,

Feitosa²,

Moura³

et al. 2022

Revista Brasileira De Oftalmologia

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Objective: To assess the deaths caused by eye cancer from 2010 to 2019 in Brazil.Methods: Data were selected from SUS' Computer Department platform at the Ministry of Health , including death certificates, from 2010 to 2019, from all Brazilian states and the Federal District, filtering the codes C69.0 to C69.9 as the cause of death, according to the International Classification of Diseases,Tenth Revision.Results:There were 1,859 deaths from malignant neoplasm of eye and adnexa (C69), in Brazil, from 2010 to 2019, affecting 1,062 (57.1%) men. The site of neoplasm was unspecified (C69.9) in 719 cases, representing the most frequent etiology in the C69 group (38.67%). The malignant neoplasm of the orbit (C69.6) was the second most common cause of death (22.59%), followed by malignant neoplasm of retina (C69.2) (14.73%). Conclusion:The number of deaths due to malignant neoplasm of eye and adnexa slightly increased through the years of 2010 to 2019, in Brazil. RESUMOObjetivo: Avaliar os óbitos causados por câncer ocular durante os anos de 2010 a 2019 no Brasil.Métodos: Os dados foram selecionados na plataforma do Departamento de Informática do SUS do Ministério da Saúde, incluindo declarações de óbito, durante os anos de 2010 a 2019, de todos os estados brasileiros e do Distrito Federal, filtrando os códigos C69.0 a C69.9 como causa básica de óbito, de acordo com a Classificação Internacional de Doenças e Problemas Relacionados à Saúde -10ª Revisão.Resultados: Houve 1.859 óbitos por neoplasia maligna de olho e anexos (C69), no Brasil, no período de 2010 a 2019, acometendo 1.062 (57,1%) homens. O sítio da neoplasia não foi especificado (C69.9) em 719 casos, representando a etiologia mais frequente no grupo C69 (38,67%). A neoplasia maligna da órbita (C69.6) foi a segunda causa mais comum de óbito (22,59%), seguida pela neoplasia maligna da retina (C69.2) (14,73%).Conclusão: O número de óbitos por neoplasia maligna de olho e anexos aumentou discretamente ao longo dos anos de 2010 a 2019, no Brasil.

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The Amazon Ocular Oncology Center: The first three years

Cited by 3 publications

References 9 publications

Epidemiology of uveal melanoma in Brazil

Epidemiology of uveal melanoma in Brazil

The clinicopathological analysis of ocular and orbit tumors in southeast of China

Analysis of the mortality by eye cancer from 2010 to 2019 in Brazil

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