The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era

Taylor, Emma; Aguilar-Ancori, Elsa Gladys; Banyard, Ashley C.; Abel, Ísis; Mantini-Briggs, Clara; Briggs, Charles L.; Carrillo, Carolina; Gavidia, César; Castillo-Neyra, Ricardo; Parola, Alejandro D; Villena, Fredy E; Prada, Joaquín M.; Petersen, Brett W.; Pérez, Néstor Falcón; Sánchez, César; Sihuincha, Moisés; Streicker, Daniel G.; Várgas, Ciro Maguiña; Vela, Ana Maria Navarro; Vigilato, Marco Antonio Natal; Fan, Hui Wen; Horton, Daniel; Recuenco, Sergio

doi:10.1093/inthealth/ihac048

Cited by 10 publications

(7 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the use of PrEP for individuals under occupational risk (e.g., veterinarians, laboratory workers, wildlife biologists, etc.) or travelers, administration to communities at risk is also being reevaluated (Royal et al 2022 ; Taylor et al 2022 ). Considering more than 12 million exposures per year, human PEP is also highly effective when administered appropriately and in a timely manner, with only 122 failures identified between 1980 and 2022 (Whitehouse et al 2022 ).…”

Section: Robust Biologicsmentioning

confidence: 99%

Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism

et al. 2023

View full text Add to dashboard Cite

Rabies is an ancient disease. Two centuries since Pasteur, fundamental progress occurred in virology, vaccinology, and diagnostics—and an understanding of pathobiology and epizootiology of rabies in testament to One Health—before common terminological coinage. Prevention, control, selective elimination, and even the unthinkable—occasional treatment—of this zoonosis dawned by the twenty-first century. However, in contrast to smallpox and rinderpest, eradication is a wishful misnomer applied to rabies, particularly post-COVID-19 pandemic. Reasons are minion. Polyhostality encompasses bats and mesocarnivores, but other mammals represent a diverse spectrum of potential hosts. While rabies virus is the classical member of the genus, other species of lyssaviruses also cause the disease. Some reservoirs remain cryptic. Although global, this viral encephalitis is untreatable and often ignored. As with other neglected diseases, laboratory-based surveillance falls short of the notifiable ideal, especially in lower- and middle-income countries. Calculation of actual burden defaults to a flux within broad health economic models. Competing priorities, lack of defined, long-term international donors, and shrinking local champions challenge human prophylaxis and mass dog vaccination toward targets of 2030 for even canine rabies impacts. For prevention, all licensed vaccines are delivered to the individual, whether parenteral or oral–essentially ‘one and done’. Exploiting mammalian social behaviors, future ‘spreadable vaccines’ might increase the proportion of immunized hosts per unit effort. However, the release of replication-competent, genetically modified organisms selectively engineered to spread intentionally throughout a population raises significant biological, ethical, and regulatory issues in need of broader, transdisciplinary discourse. How this rather curious idea will evolve toward actual unconventional prevention, control, or elimination in the near term remains debatable. In the interim, more precise terminology and realistic expectations serve as the norm for diverse, collective constituents to maintain progress in the field.

show abstract

Section: Robust Biologicsmentioning

confidence: 99%

Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Additionally, it is crucial to highlight the importance of collaboration between different sectors to address the challenges related to rabies. Through this collaboration, comprehensive strategies can be developed to meet the needs of affected communities, overcoming limitations imposed by the lack of resources and the infrastructure of affected communities [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Empowering Riverine Communities in the Amazon: Strategies for Preventing Rabies

Silva,

Gomes

et al. 2024

IJERPH

View full text Add to dashboard Cite

Rabies, caused by the Lyssavirus genus, is a highly lethal zoonotic disease transmitted by animals such as bats and domestic and wild carnivores to humans, claiming nearly 100% of lives. In Brazil, recent evidence suggests an increasing role of bats in human deaths from rabies, particularly in the Amazon region. This neglected tropical disease disproportionately affects impoverished and vulnerable populations in rural areas, where approximately 80% of human cases are concentrated. This article presents research conducted in riverine communities of the Tapajós/Arapiuns Extractive Reserve in Brazil to combat rabies in September 2022. The study adopted a participatory and collaborative approach, involving community members, healthcare professionals, and educators. Prioritizing proactive interventions, the health team administered prophylactic vaccinations to 30 individuals residing in communities exposed to the Lyssavirus. Educational activities focused on dispelling myths and raising awareness about preventive measures, with 100% of individuals reporting prior doubts about the disease, emphasizing the essential nature of the clarification, especially regarding preventive aspects. This study underscores the importance of community involvement, personalized interventions, and ongoing education to effectively combat rabies. By reinforcing public health policies and promoting health education, we can empower communities to take proactive measures in rabies prevention, leading to a reduction in incidence and an improvement in quality of life.

show abstract

“…There is therefore an urgent need to acquire regional information on neglected tropical diseases will not only promote progress in research but will also be imperative. This will direct health decision-making and policy development for countries and communities in all regions of the Amazon, focusing on prevention and control as well as coordinated collaborative and multidisciplinary strategies for a One Health approach to diseases such as CD [8,20].…”

Section: Category 3 -Control and Transmission Factors Of Chagas Diseasementioning

confidence: 99%

Health-disease Process of Acute Chagas Disease According to One Health Approach

Graça,

Quaresma

2024

ACRI

View full text Add to dashboard Cite

One Health approach emerges as an innovative perspective to understand the health-disease process of acute Chagas disease (ACD). This study aimed to identify scientific evidence on the health-disease process of ACD through one health approach. This integrative literature review study had as guiding question: what is the current scientific evidence on the health-disease process of ACD according to One Health approach? A greater number of studies can be seen from 2021. The following categories were defined from the 13 studies found: One Health approach to Chagas disease; Spatial epidemiology of Chagas disease; Control and transmission factors of Chagas disease; Health indicators in Chagas disease; and Educational technology in Chagas disease. The results of this literature review, while showing greater proportions of studies involving ACD control and transmission, also demonstrate fields of study that are still little explored by national and international scientific literature, such as in the field of technologies for ACD, reflecting a large gap to be filled with future research on ACD. This study contributed to expanding the debate on the importance of an integrative approach in health research and encouraging the search for more comprehensive solutions for ACD.

show abstract

The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era

Cited by 10 publications

References 54 publications

Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism

Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism

Empowering Riverine Communities in the Amazon: Strategies for Preventing Rabies

Health-disease Process of Acute Chagas Disease According to One Health Approach

Contact Info

Product

Resources

About