The ameliorative role of Physalis pubescens L. against neurological impairment associated with streptozotocin induced diabetes in rats

Ali, Atef; Essawy, Ehab; Hamed, Heba S.; Moneim, Ahmed E. Abdel; Attaby, Fawzy A.

doi:10.1007/s11011-021-00730-7

Cited by 7 publications

(2 citation statements)

References 45 publications

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“…Low levels for any kind of neurotransmitter can lead to disease development. The current study examines the levels of several important neurotransmitters in rats with STZ-induced diabetes, and they had lower levels of ACh, serotonin, and dopamine as compared to control, while hippocampal activities of AChE and MAO were increased compared to the control, in agreement with previous reports [ 27 , 28 ]. Biobran treatment of diabetic animals led to significantly elevated ( p < 0.05) monoamine neurotransmitter levels relative to the diabetic group while decreasing hippocampal AChE and MAO activities.…”

Section: Discussionsupporting

confidence: 90%

Efficiency of Biobran/MGN‐3, an Arabinoxylan Rice Bran, in Attenuating Diabetes‐Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF‐κB in Rats

Abdou,

Hamaad,

Abd Elmageed

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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Type 2 diabetes mellitus (T2DM) is a common metabolic disease accompanied by cognitive impairment, hippocampal malfunctioning, and inflammation. Biobran/MGN-3, an arabinoxylan rice bran, has been shown to have an antidiabetic effect in streptozotocin-induced diabetic rats. The present study investigates Biobran’s effect against diabetes-induced cognitive impairment and synaptotoxicity in the hippocampus via oxidative stress and the IR/A/NF-κB signaling pathway in rats. Diabetes was induced via i.p. injection of streptozotocin (STZ) (40 mg/kg BW); STZ-treated rats were then administered Biobran (100 mg/kg BW) for 4 wks. Biobran supplementation improved motor coordination and muscular strength, as assessed by Kondziella’s inverted screen test. Biobran also improved concentration levels of glutathione (GSH), antioxidant enzymes, acetylcholine (ACh), dopamine, serotonin, insulin receptor (IR), and alpha serine-threonine protein kinase (Akt); it protected against elevated levels of glucose, total cholesterol, triglycerides, oxidative stress markers, TBARS, NO, AChE, and MAO; and it significantly decreased inflammatory cytokines levels of IL-1β, NF-κB, TNF-α, and amyloid β1-42. Moreover, Biobran ameliorated hippocampal histological alterations. Immunohistochemical observations showed that Biobran reduced overexpression of hippocampal synaptophysin and Ki67 relative to untreated diabetic rats. Biobran may ameliorate hippocampal alterations in diabetic rats via its antidiabetic, antiproliferative, anti-inflammatory, antiapoptotic, and antioxidant effects.

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Section: Discussionsupporting

confidence: 90%

Efficiency of Biobran/MGN‐3, an Arabinoxylan Rice Bran, in Attenuating Diabetes‐Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF‐κB in Rats

Abdou,

Hamaad,

Abd Elmageed

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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“…Blood samples were obtained by pricking the tips of their tails. On days 1, 4, 7 and 37, glucose was measured using a glucometer [ 11 , 12 ].…”

Section: Methodsmentioning

confidence: 99%

Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats

et al. 2022

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Diabetes is one of the world’s most important public health issues, impacting both public health and socioeconomic advancement; moreover, current pharmacotherapy is still insufficient. The natural flavonoid rosinidin has a long history of use in pharmaceuticals and nutritional supplements, but its role in diabetes has been unknown. The current study was intended to confirm the anti-diabetic activity of rosinidin in our laboratory setting, along with its mechanism. Streptozotocin (60 mg/kg, ip) treatment used to induce type II diabetes in rats and the test medication rosinidin was then administered orally (at doses of 10 mg/kg and 20 mg/kg) for biochemical and histopathological analysis. Treatment with rosinidin reduced negative consequences of diabetes. Rosinidin exerted a protective effect on a number of characteristics, including anti-diabetic responses (lower blood glucose, higher serum insulin and improved pancreatic function) and molecular mechanisms (favorable effects on lipid profiles, total protein, albumin, liver glycogen, proinflammatory cytokine, antioxidant and oxidative stress markers, AST, ALT and urea). Furthermore, the improved pancreatic architecture observed in tissues substantiated the favourable actions of rosinidin in STZ-induced diabetic rats.

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Physalis pubescens L. alleviates testicular disruptions associated with streptozotocin-induced diabetes in male Wistar rats, Rattus norvegicus

Ali

Essawy

Mohamed

et al. 2021

Environ Sci Pollut Res

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The ameliorative role of Physalis pubescens L. against neurological impairment associated with streptozotocin induced diabetes in rats

Cited by 7 publications

References 45 publications

Efficiency of Biobran/MGN‐3, an Arabinoxylan Rice Bran, in Attenuating Diabetes‐Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF‐κB in Rats

Efficiency of Biobran/MGN‐3, an Arabinoxylan Rice Bran, in Attenuating Diabetes‐Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF‐κB in Rats

Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats

Physalis pubescens L. alleviates testicular disruptions associated with streptozotocin-induced diabetes in male Wistar rats, Rattus norvegicus

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