The Amniotic Fluid Lecithin : Sphingomyelin Area Ratio (Lsar) in Pregnancies Complicated by Diabetes

Whitfield, C. R.; Sproule, W. B.; Brudenell, M

doi:10.1111/j.1471-0528.1973.tb02152.x

Cited by 44 publications

(10 citation statements)

References 6 publications

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“…Nevertheless, there is evidence in the literature that fetal lung maturation in pre-existing diabetes is altered 1,3,[22][23][24][25]42 .…”

Section: Discussionmentioning

confidence: 95%

“…Since the L/S ratio may be influenced by the presence of pre-existing diabetes 1,[22][23][24][25]42 , the construction of normal Table 1 Comparison of lecithin/sphingomyelin (L/S) ratio and lamellar body count (LBC) (× 1000/µl) in women who had received glucocorticoids for < 10 days prior to amniocentesis, and women who had not received glucocorticoids. Ranges are shown in parentheses curves for the L/S ratio was performed after exclusion of women with pre-existing diabetes.…”

Section: Construction Of Normal Curvesmentioning

confidence: 99%

“…Maternal diabetes has been shown to increase the probability of RDS 21 , but effects on fetal lung maturity test results are uncertain. Some authors have reported a lower L/S ratio 1,22 or a lower predictive value of the L/S ratio [23][24][25] , while others have found that L/S ratios in diabetic and non-diabetic women were comparable [25][26][27][28] , thereby questioning the accuracy of the test 29,30 . Few data are available on the relation between the diabetic status of the woman and the LBC 3,4,25 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of clinical characteristics on the lecithin/sphingomyelin ratio and lamellar body count: a cross-sectional study

Wijnberger

Kleine

Voorbij

et al. 2003

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Nevertheless, there is evidence in the literature that fetal lung maturation in pre-existing diabetes is altered 1,3,[22][23][24][25]42 .…”

Section: Discussionmentioning

confidence: 95%

Section: Construction Of Normal Curvesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of clinical characteristics on the lecithin/sphingomyelin ratio and lamellar body count: a cross-sectional study

Wijnberger

Kleine

Voorbij

et al. 2003

The Journal of Maternal-Fetal & Neonatal Medicine

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show abstract

“…3.5 Accelerated maturation/delayed maturation [56,156,173,199] In normal pregnancy there is good correlation between the L/S ratio and gestational age of the fetus. However, in about 25 percent of pregnancies, nearly all characterized äs high risk pregnancies, the L/S ratio and thus the functional maturity of the lungs of the fetus do not correlate with gestational age.…”

Section: Bubble Stability Testmentioning

confidence: 99%

“…L/S ratio may provided that the L/S ratio exceeds two. In transidecrease below two, and RDS may result despite tional L/S ratios, PG may or may not appear an L/S ratio that once was mature [199]. Problems immediately following birth and the condition such äs severe hemolytic disease, placenta previa, varies accordingly from normal to transient tachypnea to RDS.…”

Section: J Perinat Med 5(1977)mentioning

confidence: 99%

Review article

1977

Journal of Perinatal Medicine

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Most lifelong neurologic damage originales during the perinatal period. The major cause is asphyxia that almost always is preventable. Among diseases causing neonatal asphyxia, the respiratory distress syndrome (RDS) resulted in 10-15% of perinatal and 20-35% of neonatal deaths [129, 150]. The incidence of neurological handicaps in children surviving severe RDS was many times higher than in the normal population. The prime factor predisposing to perinatal mortality äs well äs RDS is prematurity. More than 90% of fatal cases of RDS were less than 35 weeks gestation, whereas term infants get RDS only occasionally. The estimated overall incidence of RDS in infants weighing less than 2500 gm is about 14% [48]. Perinatal asphyxia and asphyxia at birth are other significant factors increasing the incidence and severity of RDS [15,38,96,159]. Elective cesarean section when performed without proper assessment of the functional maturity of the fetus offers a significant risk for RDS [15,27,55,92,146,181,194]. Finally, the influence of maternal disorders to fetal well being is being appreciated increasingly.Diabetes A and B, particularly when poorly controlled, delays the functional maturity of the lungs [68,158]. RDS hasa characteristic course "beginning" within hours of birth and Clearing within one to two weeks unless fatal or there is chronic lung disease. It can be distinguished from other respiratory disorders such äs meconium aspiration syndrome, infection, congenital anomalies and type II RDS by its typical history and course, characteristic x-ray fmdings, and blood gas analyses indicating shunting of blood from the venous to the arterial System without oxygenation. During the last several years new approaches to therapy such äs intensive care nurseries, regionalization of perinatal care, fetal monitoring and specific treatments, including continuous positive pressure distension of the airways [80] and mechanical Ventilation [51,155] have improved the prognosis both for mortality and neurological sequelae.

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Lecithin/sphingomyelin Ratio versus Rapid Surfactant Test in Normal and Diabetic Pregnancies

Шарф¹,

Elrad²,

Boxer³

et al. 1976

International Journal of Gynecology & Obstetrics

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Lecithin/sphingomyelin (L/S) ratio was measured and rapid surfactant test (RST) was performed on amniotic fluid samples drawn from 60 normal and 18 diabetic pregnancies, for determination of fetal lung maturity. The results were compared to the neonatal outcome. Comparison of L/S ratio and RST demonstrates a good correlation (95%) between the two tests in normal pregnancies. In diabetic pregnancies, however, correlation is notably lower (54%). Respiratory distress syndrome (RDS) was predicted in both L/S ratio and RST in 35-40% of normal pregnancies, with 60-65% of false negative results. In diabetic pregnancies the L/S ratio was as reliable as in normal pregnancies, but the RST was less reliable, with an RDS prediction rate of 18%. The assumption is made that increased amniotic fluid volume in diabetic pregnancies, results in dilution of the surfactant giving more false negative results in RST than are seen with L/S ratio, as in the latter, by measuring the ratio between the two constituents of amniotic fluid, the dilution factor is abolished. In diabetic pregnancies, a positive RST is reliable, but with negative results, L/S ratio must be determined for correct assessment of fetal lung maturity.

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The Amniotic Fluid Lecithin : Sphingomyelin Area Ratio (Lsar) in Pregnancies Complicated by Diabetes

Cited by 44 publications

References 6 publications

The effect of clinical characteristics on the lecithin/sphingomyelin ratio and lamellar body count: a cross-sectional study

The effect of clinical characteristics on the lecithin/sphingomyelin ratio and lamellar body count: a cross-sectional study

Review article

Lecithin/sphingomyelin Ratio versus Rapid Surfactant Test in Normal and Diabetic Pregnancies

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