“…Many studies have demonstrated the efficacy of methadone maintenance therapy (MMT) in decreasing illicit drug consumption and criminal behavior, improving the rehabilitation of intravenous opiate-addicted patients, and lowering the prevalence of HIV infection (Newman, 1987;Plomp, Van der Hek, & Ader, 1996;Schottenfeld & Kleber, 1995). However, MMT is associated with several problems, including limited patient and community acceptance, and it appears not to be optimal for all subjects (Kolar, Brown, Weddington, & Ball, 1990;Schoenbaum & Selwyn, 1995 Since 2001, buprenorphine (BUP), an opiate A-receptor partial agonist, has been available for the treatment of heroin addiction, proving to be effective in reducing cravings for opiates and in blocking withdrawal symptoms, thus representing a useful alternative drug to methadone (Cozzolino et al, 2002(Cozzolino et al, , 2003Ling et al, 1998;Pani, Maremmani, Pirastu, Tagliamonte, & Gessa, 2000).…”