The Analysis between Clinicopathological Aspect of Early-Onset vs Late-Onset Colorectal Cancer and Mortality Rate

Abstract

Objective: Early-onset colorectal cancer (EOCRC) has different clinical and pathological characteristics compared to late-onset CRC (LOCRC). Mortality rate as a post-operative outcome is a patient's postoperative outcome considered based on the state of life or death. The objective of this research is to analyze the comparison between clinicopathological aspect of early-onset vs late-onset CRC as well as their correlation with the mortality rate in Indonesia to support global data. We performed a case-control study on 170 subjects with CRC from November 2021- November 2022 in Dr. Hasan Sadikin General Hospital. Data were extracted from electronic medical records Colorectal Cancer (CRC) Registry. Bivariate and correlation analyses were used to analyse the difference between variables using IBM SPSS 24.0. P<0.05 was considered statistically significant. Result: Anemia and tumor location variables were significantly different in the early-onset group compared to the late-onset group (P<0.001). It was also found that anemia (P<0.001), pathological features (P<0.001), and tumor location (P=0.013) had significantly low correlation with onset of CRC (r=0.325; r=0.397; r=0.342, respectively). There is no statistically significant correlation between the clinicopathological features of CRC in both onset and mortality rates in this study.

Intra‐tumoral tumor infiltrating Lymphocyte‐T CD8+ and chemotherapy response in colorectal cancer: A prospective observational study

“…Larger data were also needed as the tertiary hospital where this study was held only covered one part of the area in which the subjects might have similar characteristics; thus, larger areas are needed to include subjects with different characteristics to consider other factors that might this research. As the trend of colorectal cancer patients is changing, the examination of risk factors, genetic mutations, and immunological status of colorectal cancer patients has become important to implement personalized cancer treatment, especially in advanced colorectal cancer [22,[40][41][42][43][44] .…”