The Analysis of Statistical Data on Malignant Neoplasms Associated With Human P Apillomavirus

Kostin, Andrey; Старинский, В. В.; Самсонов, Ю. В.; Асратов, А. Т.

doi:10.17709/2409-2231-2016-3-1-9

Cited by 9 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Every year, more than 600,000 new cases of HPV-associated cancer are registered in the world, approximately 90% of which is cervical cancer. According to the statistics of the Russian Center for Information Technology and Epidemiological Research in Oncology of the Herzen Institute (branch of the Federal State Institute "National Medical Research Center of Radiology" of the Ministry of Health of the Russian Federation), in the structure of the incidence of malignant neoplasms of the population of the Russian Federation in 2015, cancers associated with HPV infection accounted for about 10% of the total incidence of cancer, and their total number was about 32,000 cases [6].…”

Section: Epidemiology Of Hpv-associated Pathology In Russia and Khmaomentioning

confidence: 99%

“…In the structure of female cancer incidence, cancers of the anogenital region are presented in different ways. Thus, cervical cancer in the Russian Federation occupies the 5th place (5.2%); cancer of the rectum, rectosigmoid junction, and anus, 6th place (4.6%); vulvar cancer, 20th place (0.6%); pharyngeal cancer (0.2%) and vaginal cancer (0.2%), 25-26th place; and laryngeal cancer-28th place (0.1%) [6].…”

Section: Epidemiology Of Hpv-associated Pathology In Russia and Khmaomentioning

confidence: 99%

“…The incidence of papillomavirus infection in general has also increased, which occurs in 44% of women who have seen a gynecologist. Against the background of persistent HPV of the urogenital tract, most cervical intraepithelial neoplasms develop, which in 15-20% of cases can end in oncological pathology (carcinoma in situ and invasive cancer) [3,6,9].…”

Section: Study Of the Expression Of Oncoprotein E7 In The Diagnosis Omentioning

confidence: 99%

See 2 more Smart Citations

The Importance of the Problem of HPV-Associated Diseases in KhMAO-Ugra: Vaccination of Adolescents against HPV - Problems and Prospects

Белоцерковцева¹,

Mayer²

2020

Human Papillomavirus

View full text Add to dashboard Cite

In a survey of adolescents aged 14-17 years, we found that 25% already have experience of sexual contact and they do not know the methods of contraception and neglect condoms. About 77.6% of sexually active adolescent girls had genital infection, including HPV 52.7%, highly oncogenic types 37.9%, and mixed infections 51.4%. Adolescents are extremely vulnerable to HPV-related diseases. Cervical cancer takes the 2nd place in the structure of cancer in women in KHMAO-Ugra and the 1st place at the age of 30 years. Since 2009, girls have been vaccinated against HPV in Ugra. Over 10 years, there was a 39% decrease in the incidence of anogenital warts. We meet with parents, provide information about the risks of HPV infection, expose myths, and discuss the safety and effectiveness of HPV vaccines. Our goal is to win the trust of parents in vaccines, resist anti-vaccine propaganda, increase motivation, and reduce the number of refusal.

show abstract

Section: Epidemiology Of Hpv-associated Pathology In Russia and Khmaomentioning

confidence: 99%

Section: Epidemiology Of Hpv-associated Pathology In Russia and Khmaomentioning

confidence: 99%

Section: Study Of the Expression Of Oncoprotein E7 In The Diagnosis Omentioning

confidence: 99%

See 1 more Smart Citation

The Importance of the Problem of HPV-Associated Diseases in KhMAO-Ugra: Vaccination of Adolescents against HPV - Problems and Prospects

Белоцерковцева¹,

Mayer²

2020

Human Papillomavirus

View full text Add to dashboard Cite

show abstract

The study of methylation status of WIF1 gene in patients with HPV-associated benign lesions of the skin and mucous membranes

Masyukova¹,

Киселев²,

Потекаев³

et al. 2017

Klin. dermatol. venerol.

View full text Add to dashboard Cite

Цель исследования-определить статус метилирования гена WNT-ингибирующего фактора 1 (WIF1) в доброкачественных образованиях кожи и слизистых оболочек, вызванных вирусом папилломы человека (ВПЧ). Материал и методы. Были проанализированы 32 образца биоптатов доброкачественных кожных опухолей, полученных в результате бритвенной биопсии у пациентов в возрасте от 16 до 67 лет. В группу исследования вошли удаленные доброкачественные образования кожи, вызванные ВПЧ, такие как себорейные кератомы, актинические кератомы, вульгарные бородавки, подошвенные бородавки, акрохордоны, остроконечные кондиломы, фибропапилломы. Диагноз устанавливался на основании данных анамнеза, клинической картины, результатов дерматоскопии. Из всех образцов была выделена ДНК, проведены бисульфитная конверсия, ПЦР-амплификация, секвенирование, а также статистическая обработка результатов секвенирования. Результаты. Во всех образцах выявлено гиперметилирование промотора гена WIF1. Заключение. Выявленное гиперметилирование промотора WIF1 может приводить к снижению уровня экспрессии данного гена и активации WNT-сигнального пути. Активация WNT-сигнального пути, возможно, является ключевым фактором в развитии и рецидивировании доброкачественных образований кожи, вызванных ВПЧ, однако для полного понимания эпигенетических механизмов требуются дальнейшие исследования в этом направлении. Ключевые слова: вирус папилломы человека, WNT-путь, ген WNT-ингибирующего фактора 1 (WIF1), статус метилирования, эпигенетика. The study of methylation status of WIF1 gene in patients with HPV-associated benign lesions of the skin and mucous membranes

show abstract

The role of human papillomavirus in laryngeal cancer and recurrent respiratory papillomatosis: epidemiological and clinical aspects

Kholopov,

Lyalina,

Topuzov

et al. 2024

Opuholi golovy i šei

View full text Add to dashboard Cite

In the recent decade, the number of laryngeal cancer cases increased worldwide by 23 %. Currently, laryngeal cancer morbidity and associated mortality do not show statistically significant trends toward a decrease. The main risk factors for laryngeal carcinoma are smoking, alcohol consumption, human papilloma virus (HPV) infection, recurrent respiratory papillomatosis, and genetic predisposition.Aim. To evaluate the incidence and role of HPV in etiology and clinical course of laryngeal cancer and recurrent respiratory papillomatosis.Analysis of the available literature sources published in the Medline, Pubmed, and eLibrary databases was performed. The review is based on 59 of 584 identified scientific studies. Frequency of HPV detection in laryngeal cancer tumor tissue varies and is associated with the studied country’s geographical location. The incidence of these viruses in tumor tissue varies between 2.7 and 62.6 %. Genotype 16 human papilloma virus is more common in women between the ages of 31 and 40 years and is mostly located near the glottic aperture. Genotype 6 and 11 human papilloma viruses promote development of recurrent respiratory papillomatosis of the larynx and are detected in 0–87.5 % of cases. It is noted that in patients with HPV-positive neoplasms of the larynx, better response to radiation therapy and higher survival rates are observed compared to patients without the virus. In countries where national programs of vaccination against HPV infection have been implemented, a significant decrease in the incidence of recurrent respiratory papillomatosis is observed.The incidence of HPV in laryngeal cancer and recurrent respiratory papillomatosis varies. The role of these viruses in carcinogenesis has not yet been fully understood. Clinical course of HPV-associated laryngeal carcinoma is more favorable than HPV-free laryngeal carcinoma, however, this statement requires further confirmation. Evaluation of the results of programs of vaccination against HPV and their effect on recurrent respiratory papillomatosis and laryngeal cancer morbidity is important.

show abstract

The Analysis of Statistical Data on Malignant Neoplasms Associated With Human P Apillomavirus

Cited by 9 publications

References 1 publication

The Importance of the Problem of HPV-Associated Diseases in KhMAO-Ugra: Vaccination of Adolescents against HPV - Problems and Prospects

The Importance of the Problem of HPV-Associated Diseases in KhMAO-Ugra: Vaccination of Adolescents against HPV - Problems and Prospects

The study of methylation status of WIF1 gene in patients with HPV-associated benign lesions of the skin and mucous membranes

The role of human papillomavirus in laryngeal cancer and recurrent respiratory papillomatosis: epidemiological and clinical aspects

Contact Info

Product

Resources

About