The ANGPTL8 Levels as An Important a Biochemical Markers for The Women with T2DM

Abstract

Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia, is an increasing health burden. In the last decade, various metabolic hormones have been noticed to significantly role obese and associated complications. for example of this, the adipokines or hepatokines secreted proteins from hepatocyte and adipocyteare correlate with metabolic syndrome. Angiopoietin-like protein 8 (ANGPTL8) has a novel hepatokine or adipokine, which is mostly expressed in the adipose tissue, and liver stimulates the β-cell proliferation as a pancreatic in an insulin resistance state. It's a recently discovered the endocrine regulator associated with glucose homeostasis, IR, and metabolism of lipid.Patients and Methods: Ninety women participated in this study, comprising sixty patients with diabetes mellitus type-2 and thirty healthy (sex and age -matched) as a control group. ELISA was used to assess ANGPTL8 and insulin. Standard procedures were used to measure fasting blood glucose, lipid profile, and glycated hemoglobin(HBA1c) in a certified laboratory.Results: Diabetes patients had higher levels of ANGPTL8 than the control group. The blood ANGPTL8 level in the Type-2 diabetes group varied from 4432.89±1171.09 pg/ml, while the control group's level was 2892.11±537.91pg/dl (p<0.0001). ANGPTL8 level that only was a negatively significant determinant (r = -0.343; and r = -0.293), with TC and LDL. Serum ANGPTL8 levels a positively correlated with age, BMI, insulin, HBA1c, HOMA-IR, HOMA-B, QUICKI, and HDL in T2DM group, and negatively correlated with FBG, TC, TG,LDL, and VLDL in the T2DM patients group.Conclusion: ANGPTL8 levels were found to be considerably higher in type two diabetes individuals, and they continued to rise in tandem with the decline in beta cell function. ANGPTL8 level that only was a negatively significant with total cholesterol (TC) and LDL. As a result, the level of serum ANGPTL8 may have a role in the etiology and diagnosis of Type 2 Diabetes Mellitus.