The animal‐dependent risk factors in canine T‐cell lymphomas

Jankowska, Urszula; Jagielski, Dariusz; Czopowicz, Michał; Sapierzyński, R.

doi:10.1111/vco.12164

Cited by 23 publications

(43 citation statements)

References 28 publications

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“…The same study also found a higher prevalence of TCL in dogs less than three years of age (Modiano and others 2005). Another study found that dogue de Bordeaux and boxers had a higher prevalence of TCL (Jankowska and others 2016). The higher prevalence of TCL in the boxer breed has also been described separately by Lurie and others (2004).…”

Section: Clinical Presentation and Signsmentioning

confidence: 98%

Treatment of T cell lymphoma in dogs

Moore¹

2016

Veterinary Record

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Overall, canine lymphoma remains one of the most chemotherapy-responsive cancers in the dog. In addition to the stage and the substage of disease, T cell phenotype is the most consistently important prognostic factor. T cell lymphoma (TCL) in dogs is a heterogeneous disease; dogs with a separate entity of indolent TCL can have a considerably better prognosis than dogs with other forms of lymphoma, and indolent TCL may not always require immediate treatment. In contrast, high-grade TCL is an aggressive disease, and when treated with CHOP-based protocols, dogs with this high-grade TCL have a complete remission rate as low as 40 per cent, relapse earlier and have shorter survival time than dogs with a comparable stage, high-grade B cell lymphoma. This review describes the different disease entities that comprise canine TCL, discusses prognosis for each and treatment options that appear to give the best outcomes.

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Section: Clinical Presentation and Signsmentioning

confidence: 98%

Treatment of T cell lymphoma in dogs

Moore¹

2016

Veterinary Record

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“…It is also worth emphasizing, that despite the high diagnostic accuracy of histopathology false diagnoses can still be made unless immunohistochemistry is applied, especially in low grade lymphomas (Flood-Knapik et al 2012). Such mistakes have also been observed in human non-Hodgkin lymphomas, most commonly in T zone lymphomas, which are quite common in canine patients (Uherowa et al 2002, Jankowska et al 2015.…”

Section: Classification Of Canine Lymphomasmentioning

confidence: 99%

“…In canine oncology it is especially valuable for diagnosing the most common subtypes of lymphomas (Fournel-Fleury et al 1997a, Fournel-Fleury et al 2002, Comazzi et al 2014. Recently, many authors have recommended using cytology as a sufficient diagnostic method for canine lymphomas, especially if supported by immunocytochemistry and/or flow cytometry (Messic 2008, Regan et al 2012, Martini et al 2013, Comazzi et al 2014, Curran and Thamm 2015, Fernandes et al 2015, Jankowska et al 2015. The great advantage of this method is the possibility of performing immunocytochemical staining.…”

Section: Application Of Cytology In Canine Lymphomasmentioning

confidence: 99%

“…Nonetheless, identifying lymphoma cell immunophenotype and tumor cytological classification o still remain important elements of the definitive diagnosis. As in human medicine the canine lymphoma is not one disease but a heterogeneous group of many conditions with different clinical presentations, requiring various therapeutic methods and characterized by different prognoses (Valli et al 2006, Pastor et al 2009, Ponce et al 2010, Rebhun et al 2010, Poggi et al 2013, Valli et al 2013, Jankowska et al 2015. For example, the WHO classification lists more than 30 subtypes of canine lymphoma, with a few specific subtypes which occur only in dogs.…”

Section: Classification Of Canine Lymphomasmentioning

confidence: 99%

“…The updated Kiel classification (uKc) adopted for dogs is the second classification system commonly used for canine lymphoma subtyping (Fournel-Fleury et al 1997a, Fournel-Fleury et al 2002, Sozmen et al 2005, Ponce et al 2010, Jankowska et al 2015, Fernandes et al 2015. This system is based on neoplastic cell morphology and immunophenotype, with regard to similarity to normal lymphocytes in various stages of maturity.…”

Section: Classification Of Canine Lymphomasmentioning

confidence: 99%

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Cytodiagnostics of canine lymphomas – possibilities and limitations

Sapierzyński¹,

Kliczkowska-Klarowicz²,

Jankowska³

et al. 2016

Polish Journal of Veterinary Sciences

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Malignant lymphomas are one of the most common malignant tumours occurring in dogs. The basic method of lymphoma diagnosis in human, as well as in canine oncology is histopathology supported by immunohistochemistry. It was suggested that in veterinary medicine excisional biopsy of lymph node and histopathology should be considered only where the cytologic diagnosis is equivocal or needs to be confirmed. There are at least three basic reasons for which cytological examination ought to be accepted as a sufficient and reliable diagnostic method for lymphoma in dogs. Firstly, most dog owners consider the fine-needle biopsy as an acceptable non-harmful method of sample collection. Secondly, an increasing number of studies recommend cytology as an accurate test for diagnosing and subtyping canine lymphoma. Finally, the vast majority of canine lymphoma subtypes belong to 4-5 categories characterized by a typical cytological picture. Immunocytochemical staining of cytological smears gives new diagnostic possibilities, such as detection of markers better characterizing given growth or a potential goal for target therapy in individual cases (for example inhibitors of platelet-derived growth factor).

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Ultrasonographic features of atraumatic‐pathological subcapsular splenic haematomas in two dogs with confirmed lymphoma

Boozer

Heng

Lim

et al. 2022

Vet Record Case Reports

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This report describes the ultrasonographic features of splenic subcapsular haematoma in two dogs with lymphoma. One dog presented for suspicion of pancreatitis and the other for persistent lethargy; both dogs had peripheral lymphadenomegaly. Abdominal ultrasound showed an avascular, subcapsular, hypoechoic region along the parietal surface of the spleen. Both dogs underwent exploratory laparotomy, during which a splenectomy and biopsies of the liver and lymph nodes were performed. Lymphoma was diagnosed via histopathology in both dogs. Atraumatic‐pathological splenic subcapsular haematomas have been reported in humans with lymphoma, but this is the first known report in veterinary medicine in patients with lymphoma.

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The animal‐dependent risk factors in canine T‐cell lymphomas

Cited by 23 publications

References 28 publications

Treatment of T cell lymphoma in dogs

Treatment of T cell lymphoma in dogs

Cytodiagnostics of canine lymphomas – possibilities and limitations

Ultrasonographic features of atraumatic‐pathological subcapsular splenic haematomas in two dogs with confirmed lymphoma

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