The Annulate Lamellae

Wischnitzer, Saul

doi:10.1016/s0074-7696(08)61246-2

Cited by 124 publications

(44 citation statements)

References 85 publications

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“…It has been also suggested that the annulate lamellae are derived from the nuclear envelope and function as a nucleo cytoplasmic intermediary (Swift 1956). In addition, a close spatial relationship between annulate lamellae and mitochondria (Borquist 1970), granular endoplasmic reticulum (Wischnitzer 1970), or Golgi apparatus (Maul 1970) was noted.…”

Section: Discussionmentioning

confidence: 99%

Annulate Lamellae in Erythroblasts in the Mice Splenic Colonies

Miura

Yoshida

Yamaguchi

et al. 1978

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Annulate Lamellae in Erythroblasts in the Mice Splenic Colonies

Miura

Yoshida

Yamaguchi

et al. 1978

Tohoku J. Exp. Med.

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“…Annulierte Lamellen (Porenlamellen) sind in Oocyten, embryonalen und schnell wachsenden Zellen h~iufig anzutreffen (Wischnitzer, 1970). Meist bilden sie Stapel parallel fibereinander lagernder Lamellen, wie sie mittlerweile auch in Anthozoenoocyten nachgewiesen sind.…”

Section: Diskussion D I E F R I I H E N T W I C K L U N G B I S Z U Runclassified

Reproduction and development ofAnemonia sulcata (Anthozoa, Actiniaria). II. Early development, blastula and gastrula

Schäfer

1985

Helgolander Meeresunters

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Reproduction and development of Anemonia sulcata (Anthozoa, Actiniaria). II. Early development, blastula and gastrula. Early developmental stages of the Anemonia germ are characterized by asynchronously dividing nuclei and an extreme delay of blastomere differentiation. The nuclei migrate to the periphery, whereas nutritive substances remain in the interior. Following this stage, the appearance of cell boundaries results in the formation of the blastoderm and the simultaneous division of the yolk into many fragments. Most of them are exclusively filled with reserve material; only very few contain zooxanthellae or nuclei. On the embryo's surface, conically shaped bundles of long microvilli are obvious. They appear to be less regularly arranged than the spines of oocytes before insemination. Pigment granules that have originated from fusing Golgi vesicles are crowded peripherally in the blastoderm cells. In the nucleoplasm single annulate lamellae that seem to be cut off from the nuclear envelope can frequently be found. There is no further cellular differentiation until gastrulation is completed. Though yolk-containing cellular fragments occupy nearly the whole blastocoel, entoderm formation occurs by invagination. Ultrastructural observations provide evidence of the existence of interstices between entoderm ceils that allow all nutritive substances to pass gradually into the gastric cavity. In the region of the blastoporus there are cellular processes enveloping reserve material. Presumably, these observations indicate a so-called "filtration of nutritive yolk" (Korschelt & Heider, 1909) that might represent an additional mode for the transfer of yolk-containing cellular fragments from blastocoel into gastrocoel. EINLEITUNG

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“…These AL pore complexes show gross structural similarities to that of NPCs at electron microscopy level [17,19]. Although AL structures have been extensively analyzed in male and female gametes, other proliferating non-germ cells also possess varying quantities of AL [17,19]. The functional role for these structures in any cellular processes is unclear.…”

Section: Introductionmentioning

confidence: 99%

Nup358 binds to AGO proteins through its SUMO ‐interacting motifs and promotes the association of target mRNA with miRISC

et al. 2016

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MicroRNA (miRNA)-guided mRNA repression, mediated by the miRNA-induced silencing complex (miRISC), is an important component of post-transcriptional gene silencing. However, how miRISC identifies the target mRNA in vivo is not well understood. Here, we show that the nucleoporin Nup358 plays an important role in this process. Nup358 localizes to the nuclear pore complex and to the cytoplasmic annulate lamellae (AL), and these structures dynamically associate with two mRNP granules: processing bodies (P bodies) and stress granules (SGs). Nup358 depletion disrupts P bodies and concomitantly impairs the miRNA pathway. Furthermore, Nup358 interacts with AGO and GW182 proteins and promotes the association of target mRNA with miRISC. A well-characterized SUMO-interacting motif (SIM) in Nup358 is sufficient for Nup358 to directly bind to AGO proteins. Moreover, AGO and PIWI proteins interact with SIMs derived from other SUMO-binding proteins. Our study indicates that Nup358-AGO interaction is important for miRNA-mediated gene silencing and identifies SIM as a new interacting motif for the AGO family of proteins. The findings also support a model wherein the coupling of miRISC with the target mRNA could occur at AL, specialized domains within the ER, and at the nuclear envelope.

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The Annulate Lamellae

Cited by 124 publications

References 85 publications

Annulate Lamellae in Erythroblasts in the Mice Splenic Colonies

Annulate Lamellae in Erythroblasts in the Mice Splenic Colonies

Reproduction and development ofAnemonia sulcata (Anthozoa, Actiniaria). II. Early development, blastula and gastrula

Nup358 binds to AGO proteins through its SUMO ‐interacting motifs and promotes the association of target mRNA with miRISC

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