The anti-hyperlipidemic effect and underlying mechanisms of barley (<i>Hordeum vulgare</i>L.) grass polysaccharides in mice induced by a high-fat diet

Yan, Jing-Kun; Chen, Ting-Ting; Li, Long-Qing; Liu, Fengyuan; Liu, Xiaozhen; Li, Lin

doi:10.1039/d3fo01451g

Cited by 8 publications

(2 citation statements)

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“…Hyperlipidemia (HLP) is a metabolic disorder primarily induced by the consumption of a high-fat diet (HFD) or foods rich in cholesterol [1]. Its principal manifestations involve abnormal blood lipid levels, characterized by elevated total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C), along with a diminished expression of high-density lipoprotein cholesterol (HDL-C) [2].…”

Section: Introductionmentioning

confidence: 99%

“…Its principal manifestations involve abnormal blood lipid levels, characterized by elevated total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C), along with a diminished expression of high-density lipoprotein cholesterol (HDL-C) [2]. These dysregulated lipid profiles significantly contribute to the development of cardiovascular diseases, including atherosclerosis and coronary heart disease [1]. According to certain investigations, it is projected that approximately 40% of global fatalities will be closely linked to cardiovascular disease by the year 2030 [3].…”

Section: Introductionmentioning

confidence: 99%

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Pleurotus abieticola Polysaccharide Alleviates Hyperlipidemia Symptoms via Inhibition of Nuclear Factor-κB/Signal Transducer and Activator of Transcription 3-Mediated Inflammatory Responses

Zhang,

Lin,

et al. 2023

Nutrients

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Hyperlipidemia (HLP) is a metabolic syndrome induced by obesity, which has been widely recognized as a significant threat to human health. Pleurotus abieticola, an edible lignin-degrading fungus, remains relatively understudied in terms of its bioactivity and medicinal properties. In this study, the lipid-lowering effect of Pleurotus abieticola polysaccharide (PAPS1) was systematically explored in high-fat diet (HFD)-induced HLP mice. The findings demonstrated that the administration of PAPS1 significantly inhibited bodyweight gain, ameliorated blood glucose and lipid levels, reduced fat accumulation, and mitigated hepatic injury in HLP mice. In addition, PAPS1 demonstrated the capability to increase the levels of three distinct fecal metabolites while simultaneously reducing the levels of eight other fecal metabolites in HLP mice. According to biological detection, PAPS1 reduced the hepatic level of reactive oxygen species (ROS) and pro-inflammatory factors, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β, -6, -17A, -22, and -23, and increased the expression of anti-inflammatory factor IL-10. Combined with proteomics, Western blot and immunohistochemistry analysis showed that PAPS1 exerted suppressive effects on inflammation and oxidative damage by inhibiting the nuclear factor-κB (NF-κB)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in HLP mice. These findings offer evidence supporting the effectiveness of PAPS1 as a therapeutic agent in reducing lipid levels through its targeting of chronic inflammation.

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Section: Introductionmentioning

confidence: 99%