The anti-inflammatory components from the effective fraction of Syringae Folium (ESF) and its mechanism investigation based on network pharmacology

Network Pharmacology-Based Identification of Potential Targets of Lonicerae japonicae Flos Acting on Anti-Inflammatory Effects

“…The 17 pathways with P values of less than 3 × 10 −15 were selected, and the compound-target-pathway (C-T-P) network was constructed using Cytoscape software ( Figure 10 ). In a network, nodes with high degree values indicate high interconnectedness [ 56 ]. The targets AKT1, PIK3CA, PIK3CB, and PIK3R1 were related to all 17 pathways; thus, they were recognized as key targets.…”

Antioxidant, Anti‐Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction

“…The spectroscopic data was first described except for the mass spectra. The 47 known compounds were identified as (-)-epiafzelechin (2) [52], (+)-catechin (3) [53], (-)-epicatechin (4) [40], (-)-epiafzelechin-5-O-β-D -glucoside (5) [54], wogonin (6) [55], genkwanin (7) [56], tricin (8) [57], vitexin (9) [58], tricin-7-O-β-D -glucoside (10) [59], isorhamnetin-3-O-β-D -glucoside (11) [60], astilbin (12) [61], (7S,8R)-dihydrodehydrodiconiferyl alcohol (13) [62], (7S,8R)-5-methoxydihydrodehydroconiferyl alcohol ( 14) [63], (7S,8R)-9,9 ′ -dihydroxyl-3,3 ′ -dimethoxyl-4-O-glycerol-7,8-dihydrobenzofuran-1 ′ -propanolneoligan (15) [64], (7S,8R)-dihydrodehydrodiconiferyl alcohol-4-O-β-D -glucopyranoside ( 16) [65], (7S,8R)-dihydrodehydrodiconiferyl alcohol-9 ′ -O-β-D -glucoside (17) [66], (7S,8R)-3,3′-dimethoxy-4-9-9′-trihydroxy-4′,7epoxy-5,8′-lignan-4,9-bis-O-β-D -glucopyranoside (18) [67], threo-(7S,8S)-guaiacyl-glycerol-β-O-4′-dihydroconiferyl ether (19) (26) [73], salicifoliol (27) [74], 4-ketopinoresinol (28) [75], (+)-pinoresinol (29) [76], (+)-medioresinol (30) [77], (+)-syringaresinol (31) [78], (7R,7 ′ R,7 ″ R,8S,8 ′ S,8 ″ S)-4 ′ ,4 ″ -dihydroxy-3,3 ′ ,3 ″triethoxy-7,9 ′ :7 ′ ,9-diepoxy-4,8 ″ -oxy-8,8 ′ -sesquineolignan-7 ″ ,9 ″ -diol (32) [78], (7S,7 ′ S,7 ″ S,8R,8 ′ R,8 ″ R)-4 ′ ,4 ″ -dihydroxy-3,3 ′ ,3 ″ ,5-tetramethoxy-7,9 ′ :7 ′ ,9-diepoxy-4,8 ″ -oxy-8,8 ′ -sesquineolignan-7 ″ ,9 ″ -diol (33) [78], (7R,7 ′ R,7 ″ R,8S,8 ′ S,8 ″ S)-4 ′ ,4 ″ -dihydroxy-3,3 ′ ,3 ″ ,5-tetramethoxy-7,9′:7′,9diepoxy-4,8″-oxy-8,8′-sesquineolignan-7″,9″-diol (34)…”

“…The targets related to diabetes were obtained using Comparative Toxicogenomic Database ( http://ctdbase.org/ ), Therapeutic Target Database ( http://bidd.nus.edu.sg/group/cjttd/ ), and DrugBank ( http://www.drugbank.ca/ ) database. The targets were normalized in UniPort ( http://www.uniport.org/ ) [ 27 ].…”

“…P ≤ 0.05, as the cutoff value, was calculated by the two-sided hypergeometric test method to identify enriched GO terms and the localization of the biological and molecular functions of the proteins, which indicated the relative importance of enriched GO terms and pathways. The ingredient-target network was established by Cytoscape.3.4.0 software [ 27 ].…”

Integrated Phytochemical Analysis Based on UPLC–MS/MS and Network Pharmacology Approaches to Explore the Effect of Odontites vulgaris Moench on Rheumatoid Arthritis

“…Therefore, there is an urgent need to find safe and effective drugs for the treatment of RA with fewer side effects than those currently used. In recent years, owing to the low level of ethnopharmacological adverse reactions, Ethnopharmacological Mongolian medicine has attracted attention as an alternative treatment for inflammation (Wang et al, 2020b). These Mongolian medicinal treatments exert anti-inflammatory effects through the NF-κB, MAPK, PI3K-Akt, arachidonic acid metabolism, inflammasome, and other pathways (Mao et al, 2019).…”