The antibacterial activity of four Saudi medicinal plants against clinical isolates of<i>Propionibacterium acnes</i>

Alnabati, Neama Ahmad; Al-Hejin, Ahmed M.; Noor, Samah O.; Ahmed, M. A.; Abu-Zeid, Mohamed; Mleeh, Nouf T

doi:10.1080/13102818.2021.1885992

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…The swab was placed in a screw cap tube containing 5 ml BHI broth as a transport medium. The tubes were incubated for five days at 37 °C in an anaerobic jar supplied with an anerogen sachet to create an anaerobic condition 25 , as represented in Fig. 1 .…”

Section: Methodsmentioning

confidence: 99%

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Antibacterial and hemocompatibility potentials of nano-gold-cored alginate preparation against anaerobic bacteria from acne vulgaris

Abbas,

Taha,

Sulaiman

et al. 2024

Sci Rep

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Acne is a prevalent dermatological disease, with high global incidence, and is a health menace. The current study aimed to isolate and characterize the anaerobic bacteria responsible for the condition. Causes of a total of 70 acne-based bacterium isolates obtained from patients of mild, moderate, and severe acne, 24 were Clostridium innocuum, 21 were Lactobacillus plantarum, 13 were Anaerococcus prevotii, and 12 were Peptoniphilus asaccharolyticus. Nearly 69% of males were suffering, while the rest were females at 31%. The 15–30 years old age group was the most affected. The gold/alginate nanoparticles’ nanopreparation (GANPs) produced from chloroauric acid and sodium alginate was an effective treatment against the acne conditions under the experimental conditions. The nanopreparation exhibited significant inhibitory activity against anaerobic bacterial isolates, with a minimum inhibitory concentration of 200 µg/ml for A. prevotii and P. asaccharolyticus, and 400 µg/ml for C. innocuum and L. plantarum. The in vitro efficacy of the GANPs on human blood parameters was also assessed. The concurrent results suggested potential antibacterial activity and hemocompatibility of the product, which has promise to be used as a successful antibacterial agent for acne.

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Section: Methodsmentioning

confidence: 99%

“…According to the manufacturer’s protocol, culturing media, blood agar medium, and reinforced agar were prepared. RCA supplemented with bromocresol purple as an indicator (40 mg/L) 25 was used. The swabs were anaerobically cultivated at 37 °C, for 5 days.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial and hemocompatibility potentials of nano-gold-cored alginate preparation against anaerobic bacteria from acne vulgaris

Abbas,

Taha,

Sulaiman

et al. 2024

Sci Rep

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“…The 16S rRNA gene was amplified using universal primers pA (5′-AGA GTT TGA TCC TGG CTC AG-3′) and pH (5′-ACG GGC GGT GTG TAC AAG-3′) with Promega Go-Taq Green Master Mix. PCR amplification was performed in a Biorad thermocycler with the following thermocycling profile: an initial denaturation step at 95 0 C for 3 mins, followed by 30 cycles consisting of 95 0 C for 30s, 55 0 C for 1 min and 72 0 C for 1 min, as well as a final extension step at 72 0 C for 10 mins (Alnabati et al 2021). Following the PCR amplification of the 16S rRNA gene, the PCR products with a size of 1530 bp were partially sequenced at Apical Scientific Sdn.…”

Section: S Rrna Analysis Of Bacterial Isolatesmentioning

confidence: 99%

Identification and antibiotic susceptibility profiles of anaerobic bacteria isolated from patients with acne vulgaris

Walid,

Subramaniam,

Sivasamugham

et al. 2023

J Exp Bio & Ag Sci

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Commensal bacteria like the Staphylococcal species are part of the skin microbiota, which helps maintain healthy skin. However, certain factors can lead to these commensals becoming opportunistic pathogens capable of causing diseases like acne vulgaris. Topical and systemic antibiotics have been the main treatment for acne. However, long-term antibiotic usage could result in the emergence of resistant bacterial strains and treatment failure. This study evaluated the antibiotic susceptibility patterns of anaerobic bacteria isolated from clinical acne samples. Skin swabs were collected from 50 acne patients and cultured under anaerobic conditions. The resulting bacterial isolates were identified using biochemical tests and 16S rRNA gene sequencing. The antibiotic susceptibility patterns of the confirmed isolates were determined using the disc diffusion assay for eight commonly prescribed antibiotics for acne treatment. Sequencing results revealed that S. epidermidis was the most isolated bacterial species (68%, n=34), followed by S. aureus (8%, n=4). However, a significant proportion of bacterial isolates were susceptible to all eight tested antibiotics, which is unusual. On the other hand, 26% (n=13) of the tested bacterial species isolates were found to be resistant to clindamycin, while 36% (18) were resistant to erythromycin and 20% (n=10) were to tetracycline. Since there has been limited research regarding the antibiotic resistance patterns of anaerobic acne-associated bacteria in Malaysia, this study can help shed some light on suitable local prescription practices and raise awareness about the cautious use of antibiotics in treating acne vulgaris.

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“…R. stricta organic alkaloid extract was most effective against E. coli and methicillin-resistant Staphylococcus aureus (MRSA), resulting in the disruption of cell membranes [48]. Acetone and the methanolic extract of R. stricta leaves demonstrated antibacterial activity against Propionibacterium acnes at a (50 mg/mL) minimum inhibitory concentration and zone of inhibition 25.6 ± 1.94 mm [49]. The biogenic Au nanoparticles and R. stricta extract degraded the membrane of E. coli (MIC1 425.0 mg/mL) and B. subtilis (50.0 mg/mL), and stimulated the production of reactive oxygen species, resulting in the death of microbial cells [50].…”

Section: Pharmacological Activities Of R Stricta 101 Antibacterial Activitymentioning

confidence: 99%

A Review of Rhazya stricta Decne Phytochemistry, Bioactivities, Pharmacological Activities, Toxicity, and Folkloric Medicinal Uses

Albeshri¹,

Baeshen²,

Bouback

et al. 2021

Plants

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The local medicinal plant Rhazya stricta Decne is reviewed for its folkloric medicinal, phytochemical, pharmacological, biological, and toxicological features. R. stricta has been used widely in different cultures for various medical disorders. The phytochemical studies performed on the R. stricta extract revealed many alkaloidal and fatty acid compounds. Moreover, several flavonoid and terpenoid compounds were also detected. Pharmacological activates of R. stricta extracts are approved to possess antimicrobial, antioxidant, anticancer, antidiabetic, and antihypertensive activities. Additionally, R. stricta extract was found to hold biological activates such as larvicidal and phytoremediation activates R. stricta extract was found to be toxic, genotoxic, and mutagenic. R. stricta contains novel phytochemical compounds that have not been investigated pharmacologically. Further research is needed through in vitro and in vivo experiments to pave the road for these compounds for medical, veterinary, and ecological uses.

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The antibacterial activity of four Saudi medicinal plants against clinical isolates ofPropionibacterium acnes

Cited by 7 publications

References 41 publications

Antibacterial and hemocompatibility potentials of nano-gold-cored alginate preparation against anaerobic bacteria from acne vulgaris

Antibacterial and hemocompatibility potentials of nano-gold-cored alginate preparation against anaerobic bacteria from acne vulgaris

Identification and antibiotic susceptibility profiles of anaerobic bacteria isolated from patients with acne vulgaris

A Review of Rhazya stricta Decne Phytochemistry, Bioactivities, Pharmacological Activities, Toxicity, and Folkloric Medicinal Uses

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