The anticancer effects of hispolon on lung cancer cells

Wu, Qi; Kang, Yan; Zhang, Hui; Wang, Hongmin; Liu, Yuanhua; Wang, Jing

doi:10.1016/j.bbrc.2014.09.098

Cited by 39 publications

(21 citation statements)

References 27 publications

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“…Hispolon (6-(3,4-dihydroxy-phenyl)-4-hydroxy-hexa-3,5-dien-2-one; C 12 H 12 O 4 ) is a phenolic compound isolated from Phellinus igniarius 14 ( Figure 1a ), and it has anti-inflammatory, anti-proliferative, antioxidant, and anti-tumor effects. 15 Hispolon may induce G0/G1 cell cycle arrest and apoptosis in human leukemia, nasopharyngeal carcinoma, and hepatocellular carcinoma cells 15 , 16 , 17 and enhance the expression of the cancer-suppressor gene p53 in lung cancer cells.…”

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confidence: 99%

Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells

et al. 2017

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Hispolon, a phenolic compound isolated from Phellinus igniarius, induces apoptosis and anti-tumor effects in cancers. However, the molecular mechanism involved in hispolon-mediated tumor-suppressing activities observed in cervical cancer is poorly characterized. Here, we demonstrated that treatment with hispolon inhibited cell metastasis in two cervical cancer cell lines. In addition, the downregulation of the lysosomal protease Cathepsin S (CTSS) was critical for hispolon-mediated suppression of tumor cell metastasis in both in vitro and in vivo models. Moreover, hispolon induced autophagy, which increased LC3 conversion and acidic vesicular organelle formation. Mechanistically, hispolon inhibited the cell motility of cervical cells through the extracellular signal-regulated kinase (ERK) pathway, and blocking of the ERK pathway reversed autophagy-mediated cell motility and CTSS inhibition. Our results indicate that autophagy is essential for decreasing CTSS activity to inhibit tumor metastasis by hispolon treatment in cervical cancer; this finding provides a new perspective on molecular regulation.

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Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells

et al. 2017

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“…P. igniarius has been used in traditional Chinese medicine and in other oriental countries for the treatment of various diseases, including cancer It has been reported that P. igniarius extracts have an inhibitory effect on S180 tumor growth and an immunoregulatory effect on S180-induced tumors in mice [24]. Moreover, Wu et al [25] indicated that hispolon (34) isolated from P. igniarius inhibits cell viability, induces G0/G1 cell cycle arrest and apoptosis in lung cancer cells. Further, hispolon enhanced the expression of tumor protein p53, specific silencing of which almost completely reversed hispolon-mediated antitumor activity.…”

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Phellinus igniarius: A Pharmacologically Active Polypore Mushroom

Zapora

Wołkowycki

Бакиер

et al. 2016

Natural Product Communications

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Mushrooms have been widely used in traditional medicine for the treatment of various diseases. Today, their therapeutic value is scientifically studied and appreciated. Research indicates that polypores-a large group of fungi of the phylum Basdiomycota-exhibit antiviral, antimicrobial, anticancer, anti-allergic, anti-atherogenic, hypoglycemic, hepatoprotective and anti-inflammatory activities. Phellinus igniarius, a polypore mushroom, is one of the most used in traditional Asian medicine. Its potent anticancer activity has been repeatedly reported. In the past two decades, numerous pharmacologically active metabolites have been isolated and identified from P. igniarius. Among the large number of compounds, the most active group are polysaccharides. They modulate immune responses and inhibit tumor growth.

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“…Apoptosis is a programmed cellular process that occurs in physiological and pathological conditions (Wu et al, 2014). Furthermore, the programmed cell death is disrupted in the cancer, which causes the malignant cells to grow too much.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acorus calamus plant extract on prostate cancer cell culture

Koca

Köken

Özkurt

et al. 2018

Anatolian Journal of Botany

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In western countries, prostate cancer is the most frequently diagnosed cancer and the second most common cause of death from cancer in men. Vascular endothelial growth factor-A (VEGF-A), thought to be the single most important angiogenic factor in prostat cancer. Poly-(ADP-ribose) polymerase (PARP) involved in apoptotic process and cleavage of PARP serves as a marker of cells undergoing apoptosis. Acorus calamus have long been considered to have anti-carcinogenic and medicinal properties especially in Asia. We examined whether ethanolic extract of A. calamus root affects the survival of prostate cancer LNCaP cells and induces apoptosis and angiogenesis of these cells in vitro. Cells were incubated during 24 and 48 hours with various doses of extract. Extract with these concentrations reduced the number of LNCaP living cells up to 44 % as compared to the control at dose and time dependent manner at 24 and 48 hours. Significantly alterations were observed at cleaved PARP, VEGF-A protein and gene expression amounts after 24 and 48 hours. The present study reveals the possibility that ethanolic extract of A. calamus root posseses a dose and time dependent anticancer, apoptotic and anti-angiogenic properties.

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The anticancer effects of hispolon on lung cancer cells

Cited by 39 publications

References 27 publications

Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells

Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells

Phellinus igniarius: A Pharmacologically Active Polypore Mushroom

Effects of Acorus calamus plant extract on prostate cancer cell culture

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