The anticancer properties of phytochemical extracts from Salvia plants

Jiang, Yuanyuan; Zhang, Li; Rupasinghe, HP Vasantha

doi:10.2147/btat.s98610

Cited by 8 publications

(4 citation statements)

References 111 publications

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“…The IC50 values for these were recorded to be less than 150 μg/ml (Rao, Timsina, & Nadumane, 2014). Furthermore, extracts of Saliva species especially S. miltiorrhiza and S. officinalis have been recently documented to possess high antitumor activity in vitro and in vivo (Jiang, Zhang, & Rupasinghe, 2016). Likewise, the ginger extracts have been recorded to manifest antiproliferative actions on many kinds of cancer cells, especially pancreatic cancer cells (Akimoto, Lizuka, Kanemastu, Yoshida, & Takenaga, 2015).…”

Section: Discussionmentioning

confidence: 99%

Detection of mycobiota, aflatoxigenic and ochratoxigenic genes, and cytotoxic ability in spices

El‐Dawy

Yassein

El‐Said

2019

Food Science & Nutrition

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Spices are portions of plants because their properties are used as colorants, preservatives, or medicine. The employments of spices have been known since long time, and the interest in the capability of spices is astounding because of the chemical compounds contained in spices. The molds grow on a variety of different crops and foodstuffs including spices often under warm and humid conditions. The mycobiota of five spice species were surveyed. Forty‐six fungal species were obtained. Aspergillus flavus and A. niger were the prevalent species recorded. The aflatoxins (AFs) and ochratoxins (OTs) were detected in some samples and isolates. Cumin had the highest concentration of AFs 8.2 ppb, while ginger had a considerable occurrence of OTs 6.7 ppb. A. flavus obtained from ginger recorded the maximum concentration of AFs 7.5 ppb, and A. niger from turmeric was the highest producer for OTs 3.6 ppb. omt‐A and Aopks genes were detected in all tested A . flavus isolates and two out of four A. niger isolates. One of the important properties of spices is cancer etiology and prevention. Ginger and sage were the highest cytotoxic against four human tumor cell lines.

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Section: Discussionmentioning

confidence: 99%

Detection of mycobiota, aflatoxigenic and ochratoxigenic genes, and cytotoxic ability in spices

El‐Dawy

Yassein

El‐Said

2019

Food Science & Nutrition

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“…Sage leaves are especially rich in phenolic compounds-natural antioxidants. Many studies have proven the anticancer effects of their extracts [17]. Scientific literature provides data on the anticancer effects [18][19][20][21] and antioxidant activity [22][23][24][25] of yarrow grass, calendula flowers, bearberry leaves, and apple fruit extracts.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Dietary Antioxidants from a Series of Plant Extracts as Anticancer Agents against Melanoma, Glioblastoma, and Breast Cancer

2021

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In modern society, cancer is one of the most relevant medical problems. It is important to search for promising plant raw materials whose extracts have strong antioxidant and anticancer effects. The aim of this study was to determine the composition of phenolic compounds in plant extracts, to evaluate their antioxidant and anticancer activity, and to find the correlations between those activities. Extracts of calendula, sage, bearberry, eucalyptus, yarrow, and apple were selected for the study. The phenolic compounds of these extracts were determined by the UPLC-ESI-MS/MS method and the antioxidant activity was evaluated in vitro by four different UV-VIS spectrophotometric methods (ABTS, DPPH, CUPRAC, FRAP). The anticancer activity of extracts was tested against melanoma IGR39, glioblastoma U-87, and triple-negative breast cancer MDA-MB-231 cell lines in vitro by MTT assay. The highest content of identified and quantified phenolic compounds was found in sage leaf extract and the lowest in ethanol eucalyptus leaf extract. The highest antioxidant activity was determined by all applied methods for the acetone eucalyptus leaf extract. The majority of extracts were mostly active against the melanoma IGR39 cell line, and possessed the lowest activity against the glioblastoma U-87 cell line. Acetone extract of eucalyptus leaf samples exhibited the highest anticancer activity against all tested cell lines. Strong and reliable correlation has been found between antioxidant and anticancer activity in breast cancer and glioblastoma cell lines, especially when evaluating antioxidant activity by the FRAP method.

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“…The main advantage of the neutral red assay is that it detects only viable cells [52]. Previous researches reported the antitumor properties of sage extract which probably in correlation to its announced antioxidant activity as in other plant extracts [9,53]. Sage bioactive compounds, linalyl acetate (Ly), terpeniol (Te) and camphor (Ca), has been reported to have a synergistic effect on two human colon cancer cell lines HCT-116 (p53 (+/+) and p53 (-/-)).…”

Section: Discussionmentioning

confidence: 99%

Nutrients and Constituents Relevant to Antioxidant, Antimicrobial and Anti-Breast Cancer Properties of Salvia officinalis L.

Darwish

Hamad

El-Sohaimy

2018

IJBCRR

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This work was carried out in collaboration between all authors. Author AMGD designed the study, managed the analyses of the study, performed the statistical analysis, wrote the protocol, managed the literature searches and wrote the first draft of the manuscript. Author GMH contributed in the antimicrobial analyses of the study. Author SAES contributed in the study design, interpretation of the results and revising process. All authors read and approved the final manuscript.

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The anticancer properties of phytochemical extracts from Salvia plants

Cited by 8 publications

References 111 publications

Detection of mycobiota, aflatoxigenic and ochratoxigenic genes, and cytotoxic ability in spices

Detection of mycobiota, aflatoxigenic and ochratoxigenic genes, and cytotoxic ability in spices

The Potential of Dietary Antioxidants from a Series of Plant Extracts as Anticancer Agents against Melanoma, Glioblastoma, and Breast Cancer

Nutrients and Constituents Relevant to Antioxidant, Antimicrobial and Anti-Breast Cancer Properties of Salvia officinalis L.

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