The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test

Molina-Hernández, Miguel; Téllez-Alcántara, N. Patricia; Olivera-López, Jorge I.; Jaramillo, M. Teresa

doi:10.1007/s00213-013-3251-1

Cited by 8 publications

(4 citation statements)

References 62 publications

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“…Several studies have reported that estrogen replacement therapy exerts antidepressive actions in females with depression in clinical studies, as well as females in animal models . Furthermore, estrogen can be combined with selective serotonin re‐uptake inhibitors (SSRIs), to produce additive antidepressant‐like effects . Curiously, fasting produces estrogenic effects even in ovariectomized mice, and caloric restriction increases expression of estrogen receptors (ERs) but not the expression of the androgen receptors in mouse ovaries .…”

Section: Introductionmentioning

confidence: 99%

“…8,11 Furthermore, estrogen can be combined with selective serotonin re-uptake inhibitors (SSRIs), to produce additive antidepressant-like effects. 12,13 Curiously, fasting produces estrogenic effects even in ovariectomized mice, 14 and caloric restriction increases expression of estrogen receptors (ERs) but not the expression of the androgen receptors in mouse ovaries. 15 Therefore, this study investigated the antidepressant-like effects of acute fasting combined with estrogen treatment, and the potential mechanisms that might underlie these combined antidepressant effects.…”

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confidence: 99%

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Additive antidepressant‐like effects of fasting with β‐estradiol in mice

Wang

Fan

et al. 2019

J Cellular Molecular Medi

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Our recent study has shown that acute fasting produces antidepressant‐like effects in male mice. However, there is little evidence regarding the antidepressant‐like effects of acute fasting in female mice. Moreover, it is not yet clear whether estrogen produces additive effects with acute fasting. Therefore, this study aims to investigate the antidepressant‐like effects of acute fasting plus estrogen treatment. In this study, the acute fasting produced antidepressant‐like effects in female mice and the antidepressant‐like effects of 9 hours fasting with those of β‐estradiol (E2) were additive. Activity of the cyclic adenosine monophosphate (cAMP) response element‐binding protein (CREB)‐brain‐derived neurotrophic factor (BDNF) pathway in the prefrontal cortex (PFC) and hippocampus (HP) was increased, as well as neurogenesis in the subgranular zone of the hippocampus. Serum ghrelin and estrogen were also increased by fasting plus E2. Furthermore, RNA‐seq analysis indicated that fasting and E2 co‐regulate similar gene expression pathways, underlying similar neurological functions. Taken together, these data suggest that E2 produces additive antidepressant‐like effects with fasting by activating the CREB‐BDNF pathway in the PFC and HP. Genome‐wide transcriptome mapping suggests that fasting may be used as an adjunct to estrogen replacement therapy for the treatment of depression associated with reduced estrogen function.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Additive antidepressant‐like effects of fasting with β‐estradiol in mice

Wang

Fan

et al. 2019

J Cellular Molecular Medi

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“…Intragastric administration of 1-MID in doses of 20, 40, and 80 mg/kg BW to chronic forced swim stress-induced depression model rats for 14 days obviously increased the body weight and sucrose preference via decreasing serum CORT and upregulating the expression of BDNF protein [123], suggesting that 1-MID is a promising lead compound of novel antidepressant that originated from OR, and further researches associated with lead optimization as well as structure-activity relationship will be needed to investigate. In terms of petroleum ether extract from OR, previous studies have reported that three compounds including cholesterol, cholestan-3,6-dione, and cholest-4-ene-3-one were separated from it [42], which belong to the steroids that elicit antidepressant-like activities [142–144]; however, additional experiments will still be wanted to verify whether these compounds mainly contribute to the antidepressant effect of petroleum ether extract from OR.…”

Section: Biological Functions Of Oviductus Ranaementioning

confidence: 99%

Traditional Uses, Bioactive Constituents, Biological Functions, and Safety Properties of Oviductus ranae as Functional Foods in China

Zhang

Wang

et al. 2019

Oxidative Medicine and Cellular Longevity

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Oviductus ranae is an animal-based traditional Chinese material widely used as tonics in China for hundreds of years. Various bioactive components are present in OR including proteins, amino acids, steroids, fatty acids, phospholipids, nucleosides, vitamins, hydantoins, and mineral elements. These constituents exert a myriad of biological functions such as immunomodulatory, antioxidant, antifatigue, antiaging, estrogen-like, hepatoprotective, hypolipidemic, antiosteoporotic, antidepressant, antitumor, antitussive, expectorant, anti-inflammatory, and antiasthmatic activities. Unlike other traditional Chinese crude drugs recorded in Chinese Pharmacopoeia, OR is seldom prescribed as medicine but often consumed as nutraceuticals to optimize health. In this review, the traditional uses, bioactive constituents, biological functions, and safety properties of OR as functional foods in China were summarized and discussed. It is expected that this review will provide useful information for anyone who is interested in OR.

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“…On the other hand, it has been suggested that the use of a combined therapy, estradiol plus antidepressant, could be advantageous for the treatment of depression in perimenopausal or menopausal women (Vega-Rivera et al, 2016). Some clinical studies suggest that estrogen may enhance the effect of other antidepressants (Estrada-Camarena et al, 2004), such as selective serotonin reuptake inhibitors (SSRIs) (Benmansour et al, 2016b), agomelatine (El-Khatib et al, 2020), escitalopram (Ibrahim et al, 2016), fluoxetine (Récamier-Carballo et al, 2012), and topiramate (Molina-Hernández et al, 2014). However, other studies have reported that estradiol can block the antidepressant effect of some antidepressants such as sertraline, desipramine, or fluvoxamine (Shah and Frazer, 2014;Benmansour et al, 2016aBenmansour et al, , 2016b.…”

Section: Introductionmentioning

confidence: 99%

Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats

Barbosa-Méndez,

Salazar-Juárez

2023

Behavioural Pharmacology

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Epidemiological studies have mentioned that cocaine use disorder (CUD) has increased in the last decade among women; these show endocrine and reproductive disorders and a high propensity to stress and depression disorders. Mirtazapine—a tetracyclic antidepressant—decreases cocaine-induced locomotor activity and locomotor sensitization in male rats. The objective of this study was to evaluate if estradiol alters the efficacy of mirtazapine to decrease cocaine-induced locomotor activity in sham and ovariectomized female rats. Three hundred and twenty adult female Wistar rats were assigned to three experimental protocols. For experiments, 1–3, female rats were daily dosed with 10 mg/kg of cocaine during the 10 days of induction and expression of locomotor sensitization. During drug withdrawal (30 days), cocaine was withdrawn and the groups received daily mirtazapine, estradiol, or saline. In addition, the females underwent sham or ovariectomy surgery. Tamoxifen was administered during the antagonism phase. After each administration, locomotor activity for each animal was recorded for 30 min in activity chambers. The dosage of mirtazapine reduces estradiol-induced enhancement in cocaine-dependent locomotor activity during the expression of locomotor sensitization in sham and ovariectomized female rats. As well as they showed that estradiol co-dosed with mirtazapine enhances the efficacy of mirtazapine to decrease cocaine-induced locomotor activity. Finally, tamoxifen enhanced the estradiol and mirtazapine-induced decrease in the cocaine motor effect in female rats. Mirtazapine may be considered an effective therapeutic option for the treatment of CUD in women, even in those who are on hormonal treatment or antidepressant therapy with estradiol.

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The antidepressant-like effects of topiramate alone or combined with 17β-estradiol in ovariectomized Wistar rats submitted to the forced swimming test

Abstract: Topiramate alone or combined with 17β-estradiol produced antidepressant-like actions; and 17β-estradiol shortened the onset of the antidepressant-like effects of topiramate.

Cited by 8 publications

References 62 publications

Additive antidepressant‐like effects of fasting with β‐estradiol in mice

Additive antidepressant‐like effects of fasting with β‐estradiol in mice

Traditional Uses, Bioactive Constituents, Biological Functions, and Safety Properties of Oviductus ranae as Functional Foods in China

Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats

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