The Antihormone Problem in Endocrine Therapy

Neutralization of Activity of Circulating Gonadotrophic Hormones by Antiserum to Rat Pituitary

“…Similar antihormone effects have been noted in many patients during pro¬ longed treatment with heterologous gonadotrophic hormones (Leathern, 1949). However, in most instances the hormone preparations which had been employed were of cruder nature than those which are now available, and control tests demon¬ strating the specificity of the antigen-antibody reaction concerned, even if feasible, were difficult to perform.…”

Production of Gonadotropin Antibodies in Rhesus Monkeys (Macaca mulatta)

“…The anti-SAP activity developed in the monkey exhibited a range of cross-reactivity with gonadotropins of diverse origins. C'omparable results have been obtained by immunizing horse, mice, and rabbits with sheep pituitary preparations (2,11,12). Antihormones produced against sheep gonadotropins tend to be more species aspecific (1) than those produced against crude human pituitary preparations (13) or pregnant mare's serum gonadotropin (8).…”

Polyovulation bei Haustieren

“…Angaben uber die biologische Halbwertszeit von exogenem FSH sind jedoch nur sparlich zu finden oder widersprechen sich (Tabelle 5). (LEATHEM, 1949;OSTERGAARD und HAMBURGER, 1949), Pferd (FINERTY und Mitarbeiter, 1944), Rind (CASIDA und Mitarbeiter, 1943;COLE und Mitarbeiter, 1957;NAKAHARA und Mitarbeiter, 1961), Schaf (KATZMANN und Mitarbeiter, 1939;PIGEON und Mitarbeiter, 1960), bei der Ziege (ROWLANDS, 1937) und dem Hund (THOMPSON und CUSHING, 1937) nachgewiesen. Mit Hypophysen-Extrakt der gleichen Spezies behandelte Tiere entwickeln dagegen mit einigen Ausnahmen (KATZMANN und Mitarbeiter, 1947;LEATHEM und BRADBURY, 1949) keine hemmenden Substanzen gegen das injizierte Material (KATZMANN und Mitarbeiter, 1939).…”