The antinociceptive activity of Polygonatum verticillatum rhizomes in pain models

Khan, Haroon; Saeed, Muhammad; Gilani, Anwarul Hassan; Khan, Murad Ali; Dar, Ahsana; Khan, Inamullah

doi:10.1016/j.jep.2009.10.003

Cited by 138 publications

(111 citation statements)

References 29 publications

(16 reference statements)

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“…Local peritoneal receptors are postulated to be partly involved in the abdominal constriction response (Correa and Calixto, 1993;Mbiantcha et al, 2011). The method has been associated with prostanoids in general, e.g., increased levels of PGE 2 and PGF 2α in peritoneal fluids as well as lipoxygenase products (Duarte et al, 1988;Khan et al, 2010). Therefore, the results of the acetic acid-induced writhing strongly suggest that the mechanism of action of this extract is linked partly to lipoxygenases and/or cyclo-oxygenases pathways.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

Jain

Hossain²,

Fatema³

et al. 2014

American Journal of Pharmacology and Toxicology

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Allophylus cobbe L. Raeuschel (Family-Sapindaceae) is a medicinal plant used traditionally for the treatment of various health risks like pain, inflammation, ulcers and wounds in Bangladesh. This study determined the polyphenolic compounds and evaluated the analgesic, anti-inflammatory and antioxidant effects of the ethanol extract of Allophylus cobbe leaves. High Performance Liquid Chromatography (HPLC) analysis was used to determine the polyphenolic compounds present in the extract. The analgesic activity was evaluated by hot plate and acetic acid induced writhing in mice at two different doses of 250 and 500 mg kg −1 body weight. The extract was also investigated for the anti-inflammatory effect on rats at above mentioned doses using carrageenan induced rat paw edema method. The antioxidant potential of the extract was determined in terms of radical scavenging ability of the stable 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) free radical. Preliminary phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins and glycosides in the extract. High Performance Liquid Chromatography (HPLC) analysis also confirmed the presence of polyphenolic compounds such as (+)-catechin hydrate, (-)-epicatechin, caffeic acid, p-coumaric acid and quercetin. The extract increased the licking time of hind paw when placed on a hot plate by 35.31% at 250 mg kg −1 dose which is comparable to the increase shown by diclofenac sodium (42.73%) at the 3rd h of study in hot plate test. Moreover, the extract also showed good analgesic effect in acetic acid induced writhing test. The percent inhibition of writhing response by the extract was 85.96 and 78.07% at 250 and 500 mg kg −1 doses respectively while that of the standard drug was 66.67%. Furthermore, the extract also reduced carrageenan induced paw edema formation; the most prominent inhibition was found to be 58.88% (250 mg kg −1 ) at the 3rd h of study. The DPPH radical scavenging activity of the extract increased markedly with increasing concentrations. At a concentration of 200 µg mL −1 , the scavenging activity of the ethanol extract (91.53% inhibition) was comparable to that of the standard ascorbic acid (99.3% inhibition). Our results suggest that Allophylus cobbe extract possesses significant antinociceptive, anti-inflammatory and free radical scavenging activities which may justify the folkloric use of the plant in several communities for conditions such as colic, fever, inflammatory rheumatic pains and other oxidative stress associated disorders.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

Jain

Hossain²,

Fatema³

et al. 2014

American Journal of Pharmacology and Toxicology

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“…Acute oral toxicity study of methanolic extract of A. valentinus was performed in line with OECD guideline 423 [16].…”

Section: Acute Toxicitymentioning

confidence: 99%

Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats

Larbi¹,

Meddah²,

Belkhodja³

et al. 2017

IJEAB

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“…the early phase which is characterized by immediate response to painful stimulus regarded as the neurogenic-nociceptive as a result of direct stimulation of nociceptors such as bradykinin, serotonin, histamine etc. which are released spontaneously (Chapman and Dickenson, 1992) and in this state, perception of pain is immediate and most pronounced (Khan et al, 2010). The late or delayed phase normally observed after a period of time has been linked to chronic inflammatory phase during which period several inflammatory mediators such as prostaglandins, leukotriene TB4 and other chemotactic agents are simultaneously released (Foster et al,1986).…”

Section: Acute Toxicity Effect Of the Aqueous Dried Leaf And Rhizome mentioning

confidence: 99%

Phytochemical Screening, Anti-Inflammatory and Analgesic Properties of Pentanisia Prunelloides From the Eastern Cape Province, South Africa

Mathews¹,

Oyemitana²,

Opeoluwa³

et al. 2016

Afr J Tradit Complement Altern Med

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Background Pentanisia prunelloides is a medicinal plant widely used to remedy various ailments including infections, fever and rheumatism in Eastern Cape Province of South Africa. There is scanty report on the phytochemical and biological properties of the plant; hence various solvent extracts of the dried plant materials were phytochemically screened, and its aqueous extract evaluated for acute toxicity effect, analgesic and antiinflammatory properties in rodents. Methods and Materials: Different extracts of both leaf and rhizome were obtained separately with ethanol, methanol and water. Portions of the filtrate were used for qualitative screening of secondary metabolites and remaining portions were concentrated and dried. Dried grounded leaf and rhizome of the plant were also used for quantitative screening for some major components. The aqueous extract of the leaf and rhizome were used for acute toxicity (LD 50 ) test, antiinflammatory and analgesic activities in rodents. Results: The qualitative phytochemical screening showed the presence of several phytoconstituents with saponins, flavonoids and alkaloids constituting highest constituents in the leaf and rhizome. The LD 50 of the aqueous extracts (from leaf or rhizome) was found to be ≥5000 mg/kg orally. The leaf and rhizome aqueous extract (250-500 mg/kg) significantly (p<0.01) reduced egg albumininduced paw oedema and paw licking in mice induced by formalin, signifying antinociceptive and antiinflammatory activities respectively. Conclusion It is concluded that the leaf and rhizome of P. prunelloides are rich in various phytochemicals which could be associated with their medicinal uses. The aqueous leaf and rhizome extracts are similarly non-toxic orally, showed antiinflammatory and analgesic potentials thus rationalizing its use in folkloric medicine.

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The antinociceptive activity of Polygonatum verticillatum rhizomes in pain models

Cited by 138 publications

References 29 publications

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

Anti-Inflammatory, Analgesic and Antioxidant Activities of <i>Allophylus Cobbe</i> Leaves

Chemical composition and anti-arthritic activity of Anacyclus valentinus extract on adjuvant-induced arthritis in rats

Phytochemical Screening, Anti-Inflammatory and Analgesic Properties of Pentanisia Prunelloides From the Eastern Cape Province, South Africa

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