The antral Hormone Gastrin: Structure of Gastrin

Gregory, H.; Hardy, P. M.; Jones, David S.; Kenner, G. W.; Sheppard, R. C.

doi:10.1038/204931a0

Cited by 389 publications

(93 citation statements)

References 12 publications

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“…86 Most commonly, Tyr sulfation is achieved by treatment with concentrated sulfuric acid in the cold [43][44][45][87][88][89] or with a complex of sulfur trioxide with either pyridine 38,80,84,[89][90][91][92] or DMF. 75,93,94 With concentrated sulfuric acid, control of reaction temperature and time are crucial to achieve quantitative sulfation and minimize sulfonation as a side reaction.…”

Section: Chemical Sulfation Of Peptidesmentioning

confidence: 99%

“…37 Tyr sulfation is not limited to proteins but also occurs in bioactive peptides isolated from a wide range of vertebrate and invertebrate organisms (Table I). These include peptide hormones and neuropeptides of the gastrin/cholecystokinin (CCK) family, 17,[38][39][40][41][42][43][44][45][46][47][48] Leu-enkephalin, 49 and bradykinin-related peptides, referred to as phyllokinins, from the skin of the South American frog Phyllomedusa rohdei. 50 Tyr sulfation also occurs in certain a-conotoxins that have been isolated from the venoms of various cone snail species and act as potent antagonists of neuronal nicotinic acetylcholine receptors.…”

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confidence: 99%

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Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine‐containing peptides

2008

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Section: Chemical Sulfation Of Peptidesmentioning

confidence: 99%

mentioning

confidence: 99%

Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine‐containing peptides

2008

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“…The presence of a sulfated tyrosine residue was first detected in fibrinopeptide B [1,2], then on gastrin [3] and cholecystokinin (CCK) [4] and was more recently shown to occur in a rather large number of secretory proteins, only some of which, such as immunoglobulin G IS], fibronectin [6] or procollagens [7], have been identified.…”

Section: Introductionmentioning

confidence: 99%

Apparent identity of cerebral tyrosylsulfotransferase activities using either a cholecystokinin derivative or an acidic amino acid polymer as substrate

Vargas

Schwartz

1987

FEBS Letters

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The tyrosylsulfotransferase activities of rat cerebral fractions transferring [35S]sultate groups from 3'‐phosphoadenosine 5'‐[35S]phosphosulfate to either Boc‐cholecystokinin‐8 (in non‐sulfated form) or the acidic amino acid polymer (Glu, Ala, Tyr) n (6:3:1) were compared. They appear similar regarding subcellular distribution (both being enriched in the microsomal fraction) and inhibition by an excess of the acidic amino acid polymer, NaCl or 2,6‐dichloro 4‐nitrophenol. These results obtained with artificial substrates suggest that identical (or closely similar) tyrosylsulfotransferases are responsible for sulfation of tyrosine residues of several secretory proteins from various tissues.

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“…On the other hand, participation of gastrin to the gastric phase of secretion and its chemical structure have recently been demonstrated (1). However, the gastric secretion mechanism is more complicated.…”

mentioning

confidence: 99%

Fluorescence Histochemical Findings of the Stomach Walls in Response to Ulcerogenic Stimuli in Rats

Muryobayashi

Fujiwara

Shimamoto

1968

Japanese Journal of Pharmacology

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Depending upon the origin of the stimuli which signal the secretion of gastric juice, three distinct aspects of secretion have been elucidated: the cephalic, gastric and intestinal. The efferent cholinergic mechanism is involved in the cephalic phase of gastic secretion, because cutting of the vagi just above the stomach completely eliminates the secretion.On the other hand, participation of gastrin to the gastric phase of secretion and its chemical structure have recently been demonstrated (1). However, the gastric secretion mechanism is more complicated. It is possible that the intact cholinergic innervation (2) and the presence of endogenous monoamines in the gastric wall (3) are the prerequisite to the gast rin-induced gastric secretion.There are controversial reports regarding the effect of adrenergic stimuli on the gastric secretion (4-7). In the mucous membrane of the glandular portion of the rat stomach, dopa-decarboxylase activity is high (8), but the high activity is not explained by the number of mast cells (9) and adrenergic nerves (10, 11) in the gastric mucosa. The distribution of the enterochromaffin cells is also different from that of gastric dopa decarboxylase (8). Intraperitoneal injection of dopa or 5-hydroxytryptophan (5-HTP) to rats causes a marked increase in the concentration of dopamine and 5-hydroxytryptamine (5-HT) in the gastric mucosa, and the amines are located to an enterochromaffin-like cell system in the pyloric part of the gastric mucosa (8). However, the physiological significance of the uptake and decarboxylation of dopa or 5-HT remains to be settled.In the present experiments the distribution of the endogenous monoamines in the structures of the gastric wall of the rat was studied using a formaldehyde fluorescence tech nique (12, 13). The temporal changes of the monoamine fluorescence were also followed in the course of formation of the gastric ulcers in the Shay rat and the restraint, cold exposed rat. METHODSMale and female \Vistar rats weighing 150 to 200 g were used.They were housed in an individual cage at the room temperature of 22± 1 C at least for one week prior to

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The antral Hormone Gastrin: Structure of Gastrin

Cited by 389 publications

References 12 publications

Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine‐containing peptides

Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine‐containing peptides

Apparent identity of cerebral tyrosylsulfotransferase activities using either a cholecystokinin derivative or an acidic amino acid polymer as substrate

Fluorescence Histochemical Findings of the Stomach Walls in Response to Ulcerogenic Stimuli in Rats

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