The apheresis content analysis in Allo-HSCT represents reliable influential factors on graft-versus-host disease and overall survival

Rauofi, Atefeh; Hajifathali, Abbas; Karami, Samira; Tavakoli, Farzaneh; Roshandel, Elham; Bonakchi, Hossein; Parkhideh, Sayeh

doi:10.1016/j.transci.2020.103009

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…In our study, aGVHD was observed in 59 (29.6%) patients and 9 (18%) of our patients developed cGVHD. Previous studies have reported the recipient, donor age, and donor-recipient gender as crucial risk factors for incidence of GVHD in allo-HSCT ( 22 , 23 ). Our results have revealed that recipient and donor age were not significantly related to GVHD incidence.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Graft-Versus-Host Disease in the Iranian Allogeneic Hematopoietic Stem Cell Transplantation: A 10-Year Experience

Mehdizadeh

Parkhideh

Salari

et al. 2021

Med. J. Islam. Republ. Iran

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Section: Discussionmentioning

confidence: 99%

Risk Factors of Graft-Versus-Host Disease in the Iranian Allogeneic Hematopoietic Stem Cell Transplantation: A 10-Year Experience

Mehdizadeh

Parkhideh

Salari

et al. 2021

Med. J. Islam. Republ. Iran

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“… 43 In a study with 256 patients, Urbano‐Ispizua et al 41 concluded that the patients with less than 0.2 × 10 6 /kg CD3+ cells in the graft were at risk of graft failure. Rauofi et al 44 stated that the rate of cGVHD was decreased in patients with CD3+ <365 × 10 6 /kg compared to patients with CD3+ >365 × 10 6 /kg. Contrarily, Chang et al 45 declared that higher counts of CD3+ cells (median, 1.64 × 10 8 /kg) might be a guarantee to sustain the engraftment.…”

Section: Discussionmentioning

confidence: 99%

The effect of granulocyte colony‐stimulating factor dose and administration interval after allogeneic hematopoietic cell transplantation on early engraftment of neutrophil and platelet

Noorazar

Bonakchi

Sankanian

et al. 2021

Clinical Laboratory Analysis

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Background Hematopoietic stem cell transplantation (HSCT) is one of the treatments for hematologic malignancies. Numerous factors affect the HSCT outcome. The purpose of this study was to investigate the effect of post‐HSCT administration of granulocyte colony‐stimulating factor (post‐G‐CSF) on early neutrophil and platelet engraftment in allogeneic HSCT (allo‐HSCT). Material & methods The study was performed on 76 patients diagnosed with AML and ALL. All patients underwent allo‐HSCT at Taleghani stem cell transplantation center, Tehran, Iran, from February 2016 to December 2018. Chemotherapy regimens based on patients' conditions were selected between myeloablative and reduced‐intensity regimens. Results Statistical analysis revealed that the number of administered G‐CSF units after HSCT was a time‐dependent variable. Statistical analysis before day +11 reported that patients who received G‐CSF <14 units had three times better early neutrophil engraftment than those with G‐CSF ≥14 (CI 95%, AHR = 3.03, p:0.002). CD3+ cells count <318.5 × 106/kg was associated with fast platelet engraftment (CI 95%, AHR 2.28, p:0.01). Conclusion In this study, post‐G‐CSF stimulation was associated with early engraftment in a time‐ and dose‐dependent manner. Administration of G‐CSF beyond 14 units resulted in adverse effects on neutrophil early engraftment. It also appeared that with a reduction in CD3+ cell counts, the likelihood of GVHD decreases, and platelet engraftment occurs earlier. Further investigations in the future are required to determine the factors affecting the process of early engraftment.

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A novel prognostic scoring system for AML patients undergoing allogeneic hematopoietic stem cell transplantation with real world validation

Wang,

Han,

et al. 2024

Journal of Advanced Research

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The apheresis content analysis in Allo-HSCT represents reliable influential factors on graft-versus-host disease and overall survival

Cited by 6 publications

References 25 publications

Risk Factors of Graft-Versus-Host Disease in the Iranian Allogeneic Hematopoietic Stem Cell Transplantation: A 10-Year Experience

Risk Factors of Graft-Versus-Host Disease in the Iranian Allogeneic Hematopoietic Stem Cell Transplantation: A 10-Year Experience

The effect of granulocyte colony‐stimulating factor dose and administration interval after allogeneic hematopoietic cell transplantation on early engraftment of neutrophil and platelet

A novel prognostic scoring system for AML patients undergoing allogeneic hematopoietic stem cell transplantation with real world validation

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