The APOB −516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population

Pérez-Martínez, Pablo; Pérez-Jiménez, Francisco; Ordovas, José M.; Bellido, C.; Moreno, Juan Antonio; Gomez, Purificación; Marı́n, Carmen; Puebla, Rafael Ángel Fernández de la; Paniagua, Juan Antonio Pacheco; López‐Miranda, José

doi:10.1016/j.numecd.2005.11.010

Cited by 14 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They showed that healthy middle-aged men homozygous for the -516T allele presented higher plasma LDL cholesterol levels than healthy -516C homozygous subjects. However, while this observation has not been confirmed by further works, an interaction between this polymorphism and diet was observed on glucose homeostasis [31,32].…”

Section: Introductionmentioning

confidence: 55%

“…Indeed, in a previous study, subjects homozygous for the T allele were shown to present moderately enhanced fasting plasma LDL cholesterol levels and conversely C/C subjects presented lower fasting apoB, LDL cholesterol and total cholesterol plasma concentrations compared to T carriers [39]. In contrast, a recent study did not report any modification in lipid parameters associated with this gene polymorphism [31]. Our data actually agree with this latter work since at baseline, neither apoB, nor LDL cholesterol or total cholesterol plasma concentrations were modified by the genotype.…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

Hammoud¹,

Gastaldi²,

Maillot³

et al. 2009

Genes Nutr

View full text Add to dashboard Cite

Dietary guidelines aim to control fat intake and reduce cardiovascular risk but an important interindividual variability occurs among subjects. The objective was to investigate whether the response of lipid and glucose homeostasis parameters after a three-month diet aimed at reducing cardiovascular risk could be modulated by the -516C/T polymorphism in the apolipoprotein B gene (APOB). Middle-aged men (n = 69) and women (n = 100) with moderate cardiovascular disease risk were advised to reduce total energy and fat intakes and replace saturated dietary fat by monounsaturated and polyunsaturated fat. Subjects were genotyped for APOB-516C/T polymorphism. At the entry and at the end of the three-month period, fasting and postprandial plasma lipid analyses were performed. At entry, subjects homozygous for the APOB-516 T allele exhibited significantly lower fasting plasma concentrations of apolipoprotein B 48, triglycerides and triglyceride-rich lipoproteins-triglycerides compared to C carrier subjects. After the diet period, while C carrier subjects presented a clear improvement of most biological parameters, paradoxically T/T subjects did not modify them. In addition, the apoB 48 postprandial response after a standardized mixed test meal was not improved in T/T subjects after the threemonth diet, contrary to C allele carriers. Even though their phenotype at entry does not show any significant increase of risk factors when compared to other groups, subjects homozygous for the APOB-516 T allele are unresponsive to a healthy diet that improves cardiovascular risk status in the whole population.

show abstract

Section: Introductionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 80%

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

Hammoud¹,

Gastaldi²,

Maillot³

et al. 2009

Genes Nutr

View full text Add to dashboard Cite

show abstract

“…However, we did not find any statistically significant differences between the C/C and C/T groups of patients in respect to all these levels ( P > 0.05). Similarly, a study conducted by Perez‐Martinez et al suggested that the ApoB‐516C/T polymorphism does not affect the lipid profile even after the changes in the dietary fat intake in a healthy population. In contrast, reported higher plasma levels of ApoB and LDL in −516T allele carriers patients with the polymorphic genotypes (C/T and T/T) than homozygous of the −516C allele ( P < 0.001).…”

Section: Discussionmentioning

confidence: 92%

Role of ApoB‐516C/T promoter gene polymorphism in the risk of Hepatitis C virus infection in Egyptian patients and in gender susceptibility

Khalifa

Labib

Kamel

et al. 2017

Journal of Medical Virology

View full text Add to dashboard Cite

At least 1 in 10 of the Egyptian population aged 15-59 is burdened with hepatitis C virus (HCV) infection, stamping Egypt the highest country harboring HCV worldwide. Considerable evidence supported the involvement of host genetic factors in the pathogenesis of HCV and the possibility of implementation in target therapies. ApoB gene polymorphisms are postulated to affect the susceptibility of HCV infection. Hence, we aimed to evaluate the relationship between ApoB-516C/T promoter gene polymorphism and HCV infection in a cohort of Egyptian patients and to explore whether higher levels of low-density lipoprotein (LDL) might compete with lipoviral particles (LVP) in the binding to LDL receptor (LDLR), thus escaping infection. Ninety-seven HCV patients and 96 matched controls were enrolled in this study. We genotyped ApoB-516C/T using PCR-RFLP method. ApoB concentrations were measured by immunoturbidimetric assay. The genotype and the allele frequencies of ApoB-516C/T promoter gene polymorphism in cases were statistically insignificant compared with healthy individuals (P = 0.109, 0.125, respectively). Sex stratification showed significantly lower counts of C/T genotype in female patients compared with female controls (P = 0.011, OR = 0.132, 95% CI = 0.026-0.657). Significantly higher levels of LDL and ApoB were detected in the control group (P < 0.001). This study shows that the ApoB-516C/T promoter gene polymorphism has no impact on the risk of HCV infection. However, the C/T genotype may be a protective factor for our female cohort. Further studies with larger samples are needed to verify this genetic gender diversity. Additionally, high levels of LDL and ApoB might prevent HCV infection.

show abstract

“…In one study, while another ApoB SNP (rs676210) was associated with lowering of TG, SNPlcar 2 (rs934197:T/C) was not (46) , a finding replicated by at least one other study. (47) However, two recent studies detected an association between the “T” allele dosage of that SNP and higher postprandial TG level, (48) and increased insulin resistance. (49) In our study, prior to correction for multiple testing (Table 2 and OMS3 ), the ApoB -516 “C” allele dosage (SNPlcar 2( ApoB ) ) yielded an inverse association with MetS (OR=0.72; 95%CI:0.52–1.00; p=0.048) and elevated CRP (OR=0.70;95%CI:0.51–0.95, p=0.022) that was consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

Gene polymorphisms and gene scores linked to low serum carotenoid status and their associations with metabolic disturbance and depressive symptoms in African-American adults

et al. 2014

View full text Add to dashboard Cite

Gene polymorphisms provide means to obtain unconfounded associations between carotenoids and various health outcomes. We tested whether gene polymophorisms and gene scores linked to serum carotenoid status are related to metabolic disturbance and depressive symptoms in African-American adults residing in Baltimore city, MD, using cross-sectional data from the Healthy Aging in Neighborhood of Diversity Across the Lifespan (HANDLS) study (Age range:30–64y, N=873–994). We examined 24 single nucleotide polymorphisms of various gene loci that were previously shown to be associated with low serum carotenoid status (SNPlcar). Genetic risk scores (5 low specific-carotenoid risk scores (LSCRS: α-carotene, β-carotene, lutein+zeaxanthin, β-cryptoxanthin, lycopene) and 1 low total-carotenoid risk score (LTCRS: total carotenoids)) were created. SNPlcar, LSCRS and LTCRS were entered as predictors for a number of health outcomes. Those included obesity, National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III metabolic syndrome (MetS) and its components, elevated homeostatic model assessment, Insulin Resistance (HOMA-IR), C-reactive protein (CRP), hyperuricemia and elevated depressive symptoms (EDS, Center for Epidemiologic Studies-Depression (CES-D) score≥16). Among key findings, SNPlcar were not associated with the main outcomes after correction for multiple testing. However, an inverse association was found between LTCRS and HDL-C dyslipidemia. Specifically, the α-carotene and β-cryptoxanthin LSCRS were associated with lower odds of HDL-C dyslipidemia. However, the β-cryptoxanthin LSCRS was linked to a higher odds of EDS, with a linear dose-response relationship. In sum, gene risk scores linked to low serum carotenoids had mixed effects on HDL-C dyslipidemia and EDS. Further studies using larger African-American samples are needed.

show abstract

The APOB −516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population

Cited by 14 publications

References 19 publications

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

APOB-516 T allele homozygous subjects are unresponsive to dietary changes in a three-month primary intervention study targeted to reduce fat intake

Role of ApoB‐516C/T promoter gene polymorphism in the risk of Hepatitis C virus infection in Egyptian patients and in gender susceptibility

Gene polymorphisms and gene scores linked to low serum carotenoid status and their associations with metabolic disturbance and depressive symptoms in African-American adults

Contact Info

Product

Resources

About