The appearance of Mazabraud’s syndrome on 18F-FDG PET/CT

Singnurkar, Amit; Phancao, Jean-Pierre; Chatha, Deep S.; Stern, Jerry

doi:10.1007/s00256-007-0336-0

Cited by 17 publications

(8 citation statements)

References 14 publications

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“…CT scans of myxomas typically display a homogeneous, well-circumscribed mass with low attenuation. The appearance of Mazabraud's syndrome by 18F-FDG PET/CT, reported in one patient previously (5), was in agreement with our findings. A relatively low but not insignificant 18F-FDG uptake in the multiple intramuscular myxomas was described with a SUV range between 1.3 and 2.6.…”

Section: Discussionsupporting

confidence: 93%

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Mazabraud's syndrome: case report and literature review

Munksgaard¹,

Salkus

Iyer³

et al. 2013

Acta Radiologica Short Reports

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Mazabraud's syndrome is a rare disorder characterized by the association of single or multiple intramuscular myxomas with fibrous dysplasia. Here, we present the first case of Mazabraud's syndrome visualized on 18F-FDG PET/CT with histopathological confirmation of the myxoma. Our case demonstrates a slightly increased FDG uptake (SUVmax 2.1) within the myxomas and a moderately to highly increased tracer uptake (SUVmax 7.0) within the fibrous dysplastic lesions. The typical histological appearance of the intramuscular myxoma confirmed the radiological diagnosis. Further, we discuss the imaging findings and the histopathological features of this rare case with a review of the related literature.

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Section: Discussionsupporting

confidence: 93%

“…The sclerotic rim is observed as a band of low signal intensity on both T1- and T2-weighted sequences (11, 12). CT helps to indicate the extent of bone involvement and demonstrates the mild osseous expansion associated with the characteristic ground glass appearance (5, 7, 11). …”

Section: Discussionmentioning

confidence: 99%

Mazabraud's syndrome: case report and literature review

Munksgaard¹,

Salkus

Iyer³

et al. 2013

Acta Radiologica Short Reports

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“…In that report, the maximum SUV was 1.8 and FDG activity was predominantly located in the periphery of the lesion. Moreover, an appearance of Mazabraud’s syndrome on FDG PET has been described and the SUV range for the intramuscular myxoma lesions was between 1.3 and a maximum of 2.6 [13]. Our case and others suggest that intramuscular myxoma has a mild FDG uptake.…”

Section: Discussionsupporting

confidence: 58%

FDG PET/CT and MR imaging of intramuscular myxoma in the gluteus maximus

Nishio

Naito

2012

World J Surg Onc

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Intramuscular myxoma is a rare benign soft tissue tumor which may be mistaken for other benign and low-grade malignant myxoid neoplasms. We present the case of a 63-year-old woman with an asymptomatic intramuscular myxoma discovered incidentally on a whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography. PET images showed a mild FDG uptake (maximum standardized uptake value, 1.78) in the left gluteus maximus. Subsequent magnetic resonance (MR) imaging revealed a well-defined ovoid mass with homogenous low signal intensity on T1-weighted sequences and markedly high signal intensity on T2-weighted sequences. Contrast-enhanced MR images showed heterogeneous enhancement throughout the mass. The diagnosis of intramuscular myxoma was confirmed on histopathology after surgical excision of the tumor. The patient had no local recurrence at one year follow-up. Our case suggests that intramuscular myxoma should be considered in the differential diagnosis of an oval-shaped intramuscular soft tissue mass with a mild FDG uptake.

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“…reported a case and found 67 additional cases in the literature [6]. To our knowledge, 12 other cases have been reported since then [7][8][9][10][11][12][13][14][15][16][17]. Here, we report what is probably the 81st case.…”

mentioning

confidence: 46%

“…Recently introduced imaging techniques such as positronemission tomography have been used to evaluate patients with Mazabraud's syndrome [15] but are not warranted in everyday practice when standard imaging methods are used to monitor the lesions [16].…”

Section: Discussionmentioning

confidence: 99%

Mazabraud's syndrome. A case with multiple myxomas

Gaumétou

Toméno

Anract

2012

Orthopaedics & Traumatology: Surgery & Research

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Mazabraud's syndrome is defined as the combination of one or more intramuscular myxomas and fibrous dysplasia of bone. The diagnosis is important given the increased risk of malignant transformation of the bone lesions. We report a case in a 56-year-old patient with a 14-year follow-up during which multiple surgical procedures were required to remove myxomas (present at more than 15 sites). The resected myxomas were large and progressive. Unique features in this case include the long follow-up and the number of myxomas considerably above the average for this disease. Eighty other cases of Mazabraud's syndrome have been reported. The condition predominantly affects middle-aged women (mean age, 44 years). The bone lesions may be monostotic or polyostotic. Mazabraud's syndrome may be difficult to distinguish from soft-tissue sarcoma or neurofibromatosis. Identification of the underlying genetic abnormality provides diagnostic confirmation, as shown in our patient. The management consists in surgery to remove the myxomas and magnetic resonance imaging at regular intervals to monitor the lesions.

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The appearance of Mazabraud’s syndrome on 18F-FDG PET/CT

Cited by 17 publications

References 14 publications

Mazabraud's syndrome: case report and literature review

Mazabraud's syndrome: case report and literature review

FDG PET/CT and MR imaging of intramuscular myxoma in the gluteus maximus

Mazabraud's syndrome. A case with multiple myxomas

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