The Application of a Split-Conjugated Anti-Brucellosis Vaccine as a “Provocing Factor” for Identification of Brucellosis in Animals

Abstract

B rucella as an optional intracellular pathogen establishes a close relationship with the host's immune cells. Through the disruptive function of the immune system, the pathogen is able to support a chronic infection, which often makes treatment and diagnostics difficult. In recent decades, many studies have been conducted in an attempt to develop safe and effective animal brucellosis vaccines. There is no licensed vaccine for the prevention of human brucellosis. A human vaccine would be useful in protecting farmers, veterinarians, animal care workers, laboratory staff and the general population living in endemic areas of brucellosis (Dornless et al., 2015).Studies aimed at developing the ideal vaccine against brucellosis in animals and humans have been being carried out since the beginning of the twentieth century (Blasco et al., 2016).Since then, live as well as inactivated vaccines have been developed. Vaccination is the best economical measure to control brucellosis in endemic areas. Many countries have developed control measures to eradicate the disease in an-